MALDI-TOF MS as evolving cancer diagnostic tool: A review
•Up-to-date summary of MALDI-TOF MS employment in cancer diagnostics.•Highlighting of mass spectrometric cancer-related profiling.•Future perspectives in MALDI-TOF mass spectrometry of tumor samples. Recent developments in mass spectrometry have introduced clinical proteomics to the forefront of dis...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2014-07, Vol.95, p.245-255 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Merlos Rodrigo, Miguel Angel Zitka, Ondrej Krizkova, Sona Moulick, Amitava Adam, Vojtech Kizek, Rene |
| description | •Up-to-date summary of MALDI-TOF MS employment in cancer diagnostics.•Highlighting of mass spectrometric cancer-related profiling.•Future perspectives in MALDI-TOF mass spectrometry of tumor samples.
Recent developments in mass spectrometry have introduced clinical proteomics to the forefront of diseases diagnosis, offering reliable, robust and efficient analytical method for biomarker discovery and monitoring. MALDI-TOF is a powerful tool for surveying proteins and peptides comprising the realm for clinical analysis. MALDI-TOF has the potential to revolutionize cancer diagnostics by facilitating biomarker discovery, enabling tissue imaging and quantifying biomarker levels. Healthy (control) and cancerous tissues can be analyzed on the basis of mass spectrometry (MALDI-TOF) imaging to identify cancer-specific changes that may prove to be clinically useful. We review MALDI-TOF profiling techniques as tools for detection of cancer biomarkers in various cancers. We mainly discuss recent advances including period from 2011 to 2013. |
| doi_str_mv | 10.1016/j.jpba.2014.03.007 |
| format | Article |
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Recent developments in mass spectrometry have introduced clinical proteomics to the forefront of diseases diagnosis, offering reliable, robust and efficient analytical method for biomarker discovery and monitoring. MALDI-TOF is a powerful tool for surveying proteins and peptides comprising the realm for clinical analysis. MALDI-TOF has the potential to revolutionize cancer diagnostics by facilitating biomarker discovery, enabling tissue imaging and quantifying biomarker levels. Healthy (control) and cancerous tissues can be analyzed on the basis of mass spectrometry (MALDI-TOF) imaging to identify cancer-specific changes that may prove to be clinically useful. We review MALDI-TOF profiling techniques as tools for detection of cancer biomarkers in various cancers. We mainly discuss recent advances including period from 2011 to 2013.</description><subject>Biomarkers, Tumor - analysis</subject><subject>Cancer biomarkers</subject><subject>Humans</subject><subject>Imaging</subject><subject>MALDI-TOF</subject><subject>Mass spectrometry</subject><subject>Neoplasms - diagnosis</subject><subject>Reproducibility of Results</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</subject><subject>Tissue profiling</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1OwzAYRS0EoqXwAgwoI0uCf2I7RixVoVCpVQc6sFmO86VylCbFTot4e1K1MDLd5dwr3YPQLcEJwUQ8VEm1zU1CMUkTzBKM5RkakkyymIr04xwNsWQkljjjA3QVQoUx5kSll2hAU6EUE2qI1GI8f57Fq-U0WrxHJkSwb-u9a9aRNY0FHxXOrJs2dM5GXdvWj9E48rB38HWNLkpTB7g55Qitpi-ryVs8X77OJuN5bBkXXWw4gCW5wDQnkKmSSq4IK2TBSpAWSAaYK0FKYNbkRJJMUI6NkhzygkvLRuj-OLv17ecOQqc3Llioa9NAuwuacCokS2UqepQeUevbEDyUeuvdxvhvTbA-GNOVPhjTB2MaM90b60t3p_1dvoHir_KrqAeejgD0J_vjXgfroHdTOA-200Xr_tv_AaPxenA</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Merlos Rodrigo, Miguel Angel</creator><creator>Zitka, Ondrej</creator><creator>Krizkova, Sona</creator><creator>Moulick, Amitava</creator><creator>Adam, Vojtech</creator><creator>Kizek, Rene</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>MALDI-TOF MS as evolving cancer diagnostic tool: A review</title><author>Merlos Rodrigo, Miguel Angel ; Zitka, Ondrej ; Krizkova, Sona ; Moulick, Amitava ; Adam, Vojtech ; Kizek, Rene</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-a5eec1b602b1e89f275913d7d3fe7ce18e05961fe3cab17186250a975ebd57c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biomarkers, Tumor - analysis</topic><topic>Cancer biomarkers</topic><topic>Humans</topic><topic>Imaging</topic><topic>MALDI-TOF</topic><topic>Mass spectrometry</topic><topic>Neoplasms - diagnosis</topic><topic>Reproducibility of Results</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</topic><topic>Tissue profiling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Merlos Rodrigo, Miguel Angel</creatorcontrib><creatorcontrib>Zitka, Ondrej</creatorcontrib><creatorcontrib>Krizkova, Sona</creatorcontrib><creatorcontrib>Moulick, Amitava</creatorcontrib><creatorcontrib>Adam, Vojtech</creatorcontrib><creatorcontrib>Kizek, Rene</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Merlos Rodrigo, Miguel Angel</au><au>Zitka, Ondrej</au><au>Krizkova, Sona</au><au>Moulick, Amitava</au><au>Adam, Vojtech</au><au>Kizek, Rene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MALDI-TOF MS as evolving cancer diagnostic tool: A review</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>95</volume><spage>245</spage><epage>255</epage><pages>245-255</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><abstract>•Up-to-date summary of MALDI-TOF MS employment in cancer diagnostics.•Highlighting of mass spectrometric cancer-related profiling.•Future perspectives in MALDI-TOF mass spectrometry of tumor samples.
Recent developments in mass spectrometry have introduced clinical proteomics to the forefront of diseases diagnosis, offering reliable, robust and efficient analytical method for biomarker discovery and monitoring. MALDI-TOF is a powerful tool for surveying proteins and peptides comprising the realm for clinical analysis. MALDI-TOF has the potential to revolutionize cancer diagnostics by facilitating biomarker discovery, enabling tissue imaging and quantifying biomarker levels. Healthy (control) and cancerous tissues can be analyzed on the basis of mass spectrometry (MALDI-TOF) imaging to identify cancer-specific changes that may prove to be clinically useful. We review MALDI-TOF profiling techniques as tools for detection of cancer biomarkers in various cancers. We mainly discuss recent advances including period from 2011 to 2013.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>24699369</pmid><doi>10.1016/j.jpba.2014.03.007</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 2014-07, Vol.95, p.245-255 |
| issn | 0731-7085 1873-264X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biomarkers, Tumor - analysis Cancer biomarkers Humans Imaging MALDI-TOF Mass spectrometry Neoplasms - diagnosis Reproducibility of Results Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Tissue profiling |
| title | MALDI-TOF MS as evolving cancer diagnostic tool: A review |
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