Marrow-thymus interactions during radiation leukemogenesis in C57BL/Ka mice

Transplantation of thymus and bone marrow cells from irradiated C57BL/Ka mice demonstrated the presence of potentially neoplastic cells in the thymus at 30 to 60 days postirradiation. During the same interval, no such cells could be detected in the bone marrow; moreover, the capacity of bone marrow...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1981-02, Vol.41 (2), p.390-392
Hauptverfasser:	Boniver, J, Declève, A, Lieberman, M, Honsik, C, Travis, M, Kaplan, H S
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Sprache:	eng
Schlagworte:	Animals Bone Marrow - pathology Dose-Response Relationship, Radiation Leukemia, Experimental - pathology Leukemia, Radiation-Induced - pathology Mice Mice, Inbred C57BL - physiology Neoplasm Transplantation Preleukemia - pathology Thymus Thymus Gland - pathology
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creator	Boniver, J Declève, A Lieberman, M Honsik, C Travis, M Kaplan, H S
description	Transplantation of thymus and bone marrow cells from irradiated C57BL/Ka mice demonstrated the presence of potentially neoplastic cells in the thymus at 30 to 60 days postirradiation. During the same interval, no such cells could be detected in the bone marrow; moreover, the capacity of bone marrow cells to repopulate the thymus was impaired severely. These observations suggest that the primary site of neoplastic transformation in irradiated C57BL/Ka mice is the thymus rather than the bone marrow and that impaired thymic regeneration is a critical step in radiation leukemogenesis in mice.
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These observations suggest that the primary site of neoplastic transformation in irradiated C57BL/Ka mice is the thymus rather than the bone marrow and that impaired thymic regeneration is a critical step in radiation leukemogenesis in mice.</description><subject>Animals</subject><subject>Bone Marrow - pathology</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Leukemia, Experimental - pathology</subject><subject>Leukemia, Radiation-Induced - pathology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL - physiology</subject><subject>Neoplasm Transplantation</subject><subject>Preleukemia - pathology</subject><subject>Thymus</subject><subject>Thymus Gland - pathology</subject><issn>0008-5472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0E1OwzAQBWAvQKUUjoCUFbsIe2zXyRIioKhBbGAdjZ1Ja8hPsROh3p5W9ACsRu_p01vMGZtzzrNUKwMX7DLGz0PUgusZmxmlMpPBnK1fMYThJx23-26Kie9HCuhGP_Qxqafg-00SsPZ4bJKWpi_qhg31FP0RJ4U2D-XdGpPOO7pi5w22ka5Pd8E-nh7fi1Vavj2_FPdlupWcj2ktMlB2qVDI3ErVcE0ga7QOcye4Q80bR5BLiwQZGNtI7YBbyKnmRmolF-z2b3cXhu-J4lh1PjpqW-xpmGIlNCxBAf8PhDwz4gBvTnCyHdXVLvgOw746vUn-AjvbYok</recordid><startdate>19810201</startdate><enddate>19810201</enddate><creator>Boniver, J</creator><creator>Declève, A</creator><creator>Lieberman, M</creator><creator>Honsik, C</creator><creator>Travis, M</creator><creator>Kaplan, H S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>19810201</creationdate><title>Marrow-thymus interactions during radiation leukemogenesis in C57BL/Ka mice</title><author>Boniver, J ; Declève, A ; Lieberman, M ; Honsik, C ; Travis, M ; Kaplan, H S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h300t-d1824b64a139b34f05e23dabca9c10ca50fce293bae2827bf35c20b29ed073543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Bone Marrow - pathology</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Leukemia, Experimental - pathology</topic><topic>Leukemia, Radiation-Induced - pathology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL - physiology</topic><topic>Neoplasm Transplantation</topic><topic>Preleukemia - pathology</topic><topic>Thymus</topic><topic>Thymus Gland - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boniver, J</creatorcontrib><creatorcontrib>Declève, A</creatorcontrib><creatorcontrib>Lieberman, M</creatorcontrib><creatorcontrib>Honsik, C</creatorcontrib><creatorcontrib>Travis, M</creatorcontrib><creatorcontrib>Kaplan, H S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boniver, J</au><au>Declève, A</au><au>Lieberman, M</au><au>Honsik, C</au><au>Travis, M</au><au>Kaplan, H S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Marrow-thymus interactions during radiation leukemogenesis in C57BL/Ka mice</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1981-02-01</date><risdate>1981</risdate><volume>41</volume><issue>2</issue><spage>390</spage><epage>392</epage><pages>390-392</pages><issn>0008-5472</issn><abstract>Transplantation of thymus and bone marrow cells from irradiated C57BL/Ka mice demonstrated the presence of potentially neoplastic cells in the thymus at 30 to 60 days postirradiation. 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source	MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals
subjects	Animals Bone Marrow - pathology Dose-Response Relationship, Radiation Leukemia, Experimental - pathology Leukemia, Radiation-Induced - pathology Mice Mice, Inbred C57BL - physiology Neoplasm Transplantation Preleukemia - pathology Thymus Thymus Gland - pathology
title	Marrow-thymus interactions during radiation leukemogenesis in C57BL/Ka mice
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