A multitiered strategy of simulation training, kit consolidation, and electronic documentation is associated with a reduction in central line–associated bloodstream infections

Background Simulation-based training has been associated with reduced central line–associated bloodstream infection (CLABSI) rates. We measured the combined effect of simulation training, electronic medical records (EMR)-based documentation, and standardized kits on CLABSI rates in our medical (MICU...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of infection control 2014-06, Vol.42 (6), p.643-648
Hauptverfasser: Allen, Gilman B., MD, Miller, Vincent, MD, Nicholas, Cate, MS, PA, EdD, Hess, Sally, CIC, MPH, Cordes, Mari K., RN, VA-BC, Fortune, John B., MD, Blondin, Joan, RRT, MBA, Ashikaga, Takamaru, PhD, Ricci, Michael, MD
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 648
container_issue 6
container_start_page 643
container_title American journal of infection control
container_volume 42
creator Allen, Gilman B., MD
Miller, Vincent, MD
Nicholas, Cate, MS, PA, EdD
Hess, Sally, CIC, MPH
Cordes, Mari K., RN, VA-BC
Fortune, John B., MD
Blondin, Joan, RRT, MBA
Ashikaga, Takamaru, PhD
Ricci, Michael, MD
description Background Simulation-based training has been associated with reduced central line–associated bloodstream infection (CLABSI) rates. We measured the combined effect of simulation training, electronic medical records (EMR)-based documentation, and standardized kits on CLABSI rates in our medical (MICU) and surgical (SICU) intensive care units (ICU). Methods CLABSI events and catheter-days were collected for 19 months prior to and 37 months following an intervention consisting of simulation training in central line insertion for all ICU residents, incorporation of standardized, all-inclusive catheter kits, and EMR-guided documentation. Supervising physicians in the MICU (but not the SICU) also completed training. Results Following the intervention, EMR-based documentation increased from 48% to 100%, and documented compliance with hand hygiene, barrier precautions, and chlorhexidine use increased from 65%-85% to 100%. CLABSI rate in the MICU dropped from 2.72 per 1,000 catheter-days over the 19 months preceding the intervention to 0.40 per 1,000 over the 37 months following intervention ( P  = .01) but did not change in the SICU (1.09 and 1.14 per 1,000 catheter-days, P  = .86). This equated to 24 fewer than expected CLABSIs and $1,669,000 in estimated savings. Conclusion Combined simulation training, standardized all-inclusive kits, and EMR-guided documentation were associated with greater documented compliance with sterile precautions and reduced CLABSI rate in our MICU. To achieve maximal benefit, refresher training of senior physicians supervising practice at the bedside may be needed.
doi_str_mv 10.1016/j.ajic.2014.02.014
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1526134240</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0196655314001308</els_id><sourcerecordid>1526134240</sourcerecordid><originalsourceid>FETCH-LOGICAL-c469t-f68abe285eaad1dd8177c631859e161cf286c765b3f83e682de4286b944000953</originalsourceid><addsrcrecordid>eNp9kk1uFDEQhVsIRELgAiyQJYTEIjP4p9vTLUVIUcSfFIkFsLY8dnWoSbcdbDdodtyBk3AlTkJ1ZiAoC1Ylub5XLr_nqnos-FJwoV9slnaDbim5qJdcLqncqQ5FI1cLJTt9tzrkotML3TTqoHqQ84Zz3ind3K8OZN2qlRDNYfXzlI3TULAgJPAsl2QLXGxZ7FlG6tiCMTA6xYDh4phdYmEuhhwH9Ne9Y2aDZzCAKykGdMxHN40Qyk6Jmdmco0Ma69k3LJ-ZZXTT5HbtwByxyQ5swAC_vv_4h14PMXraCOxIYA_XkvywutfbIcOjfT2qPr1-9fHs7eL8_Zt3Z6fnC1frrix63do1yLYBa73wvhWrldNKtE0HQgvXy1a7lW7Wqm8V6FZ6qOlo3dX17FOjjqrnu7lXKX6ZIBczYnYwDDZAnLIho7VQtaw5oU9voZs4pUDbEaU4EZprouSOcinmnKA3VwlHm7ZGcDMHajZmDtTMgRouDRUSPdmPntYj-L-SPwkS8GwP2Ozs0CcbHOYbrm20lEoQd7LjgDz7Smmb7BCCA4-JnDU-4v_3eHlL7igwpBsvYQv55r0mk8B8mL_e_PMEuSkUb9VvfmzXvQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1530403606</pqid></control><display><type>article</type><title>A multitiered strategy of simulation training, kit consolidation, and electronic documentation is associated with a reduction in central line–associated bloodstream infections</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Allen, Gilman B., MD ; Miller, Vincent, MD ; Nicholas, Cate, MS, PA, EdD ; Hess, Sally, CIC, MPH ; Cordes, Mari K., RN, VA-BC ; Fortune, John B., MD ; Blondin, Joan, RRT, MBA ; Ashikaga, Takamaru, PhD ; Ricci, Michael, MD</creator><creatorcontrib>Allen, Gilman B., MD ; Miller, Vincent, MD ; Nicholas, Cate, MS, PA, EdD ; Hess, Sally, CIC, MPH ; Cordes, Mari K., RN, VA-BC ; Fortune, John B., MD ; Blondin, Joan, RRT, MBA ; Ashikaga, Takamaru, PhD ; Ricci, Michael, MD</creatorcontrib><description>Background Simulation-based training has been associated with reduced central line–associated bloodstream infection (CLABSI) rates. We measured the combined effect of simulation training, electronic medical records (EMR)-based documentation, and standardized kits on CLABSI rates in our medical (MICU) and surgical (SICU) intensive care units (ICU). Methods CLABSI events and catheter-days were collected for 19 months prior to and 37 months following an intervention consisting of simulation training in central line insertion for all ICU residents, incorporation of standardized, all-inclusive catheter kits, and EMR-guided documentation. Supervising physicians in the MICU (but not the SICU) also completed training. Results Following the intervention, EMR-based documentation increased from 48% to 100%, and documented compliance with hand hygiene, barrier precautions, and chlorhexidine use increased from 65%-85% to 100%. CLABSI rate in the MICU dropped from 2.72 per 1,000 catheter-days over the 19 months preceding the intervention to 0.40 per 1,000 over the 37 months following intervention ( P  = .01) but did not change in the SICU (1.09 and 1.14 per 1,000 catheter-days, P  = .86). This equated to 24 fewer than expected CLABSIs and $1,669,000 in estimated savings. Conclusion Combined simulation training, standardized all-inclusive kits, and EMR-guided documentation were associated with greater documented compliance with sterile precautions and reduced CLABSI rate in our MICU. To achieve maximal benefit, refresher training of senior physicians supervising practice at the bedside may be needed.</description><identifier>ISSN: 0196-6553</identifier><identifier>EISSN: 1527-3296</identifier><identifier>DOI: 10.1016/j.ajic.2014.02.014</identifier><identifier>PMID: 24837115</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Bacterial diseases ; Bacterial infections ; Bacterial sepsis ; Biological and medical sciences ; Blood diseases ; Catheter-related bloodstream infection ; Catheter-Related Infections - prevention &amp; control ; Catheterization, Central Venous - methods ; Central Venous Catheters - adverse effects ; Compliance ; Critical care ; Cross Infection - prevention &amp; control ; Disease control ; Documentation ; Electronic Health Records ; Electronic monitoring ; Epidemiology. Vaccinations ; General aspects ; Human bacterial diseases ; Human infectious diseases. Experimental studies and models ; Humans ; Infection Control ; Infection Control - methods ; Infectious Disease ; Infectious diseases ; Inservice Training ; Intensive care ; Intensive Care Units - standards ; Intensive Care Units - statistics &amp; numerical data ; Internship and Residency ; Medical sciences ; Sepsis - prevention &amp; control ; Simulation</subject><ispartof>American journal of infection control, 2014-06, Vol.42 (6), p.643-648</ispartof><rights>Association for Professionals in Infection Control and Epidemiology, Inc.</rights><rights>2014 Association for Professionals in Infection Control and Epidemiology, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Association for Professionals in Infection Control and Epidemiology, Inc. All rights reserved.</rights><rights>Copyright Mosby-Year Book, Inc. Jun 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-f68abe285eaad1dd8177c631859e161cf286c765b3f83e682de4286b944000953</citedby><cites>FETCH-LOGICAL-c469t-f68abe285eaad1dd8177c631859e161cf286c765b3f83e682de4286b944000953</cites><orcidid>0000-0001-5007-9069 ; 0000-0002-2472-958X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0196655314001308$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=28562231$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24837115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allen, Gilman B., MD</creatorcontrib><creatorcontrib>Miller, Vincent, MD</creatorcontrib><creatorcontrib>Nicholas, Cate, MS, PA, EdD</creatorcontrib><creatorcontrib>Hess, Sally, CIC, MPH</creatorcontrib><creatorcontrib>Cordes, Mari K., RN, VA-BC</creatorcontrib><creatorcontrib>Fortune, John B., MD</creatorcontrib><creatorcontrib>Blondin, Joan, RRT, MBA</creatorcontrib><creatorcontrib>Ashikaga, Takamaru, PhD</creatorcontrib><creatorcontrib>Ricci, Michael, MD</creatorcontrib><title>A multitiered strategy of simulation training, kit consolidation, and electronic documentation is associated with a reduction in central line–associated bloodstream infections</title><title>American journal of infection control</title><addtitle>Am J Infect Control</addtitle><description>Background Simulation-based training has been associated with reduced central line–associated bloodstream infection (CLABSI) rates. We measured the combined effect of simulation training, electronic medical records (EMR)-based documentation, and standardized kits on CLABSI rates in our medical (MICU) and surgical (SICU) intensive care units (ICU). Methods CLABSI events and catheter-days were collected for 19 months prior to and 37 months following an intervention consisting of simulation training in central line insertion for all ICU residents, incorporation of standardized, all-inclusive catheter kits, and EMR-guided documentation. Supervising physicians in the MICU (but not the SICU) also completed training. Results Following the intervention, EMR-based documentation increased from 48% to 100%, and documented compliance with hand hygiene, barrier precautions, and chlorhexidine use increased from 65%-85% to 100%. CLABSI rate in the MICU dropped from 2.72 per 1,000 catheter-days over the 19 months preceding the intervention to 0.40 per 1,000 over the 37 months following intervention ( P  = .01) but did not change in the SICU (1.09 and 1.14 per 1,000 catheter-days, P  = .86). This equated to 24 fewer than expected CLABSIs and $1,669,000 in estimated savings. Conclusion Combined simulation training, standardized all-inclusive kits, and EMR-guided documentation were associated with greater documented compliance with sterile precautions and reduced CLABSI rate in our MICU. To achieve maximal benefit, refresher training of senior physicians supervising practice at the bedside may be needed.</description><subject>Bacterial diseases</subject><subject>Bacterial infections</subject><subject>Bacterial sepsis</subject><subject>Biological and medical sciences</subject><subject>Blood diseases</subject><subject>Catheter-related bloodstream infection</subject><subject>Catheter-Related Infections - prevention &amp; control</subject><subject>Catheterization, Central Venous - methods</subject><subject>Central Venous Catheters - adverse effects</subject><subject>Compliance</subject><subject>Critical care</subject><subject>Cross Infection - prevention &amp; control</subject><subject>Disease control</subject><subject>Documentation</subject><subject>Electronic Health Records</subject><subject>Electronic monitoring</subject><subject>Epidemiology. Vaccinations</subject><subject>General aspects</subject><subject>Human bacterial diseases</subject><subject>Human infectious diseases. Experimental studies and models</subject><subject>Humans</subject><subject>Infection Control</subject><subject>Infection Control - methods</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Inservice Training</subject><subject>Intensive care</subject><subject>Intensive Care Units - standards</subject><subject>Intensive Care Units - statistics &amp; numerical data</subject><subject>Internship and Residency</subject><subject>Medical sciences</subject><subject>Sepsis - prevention &amp; control</subject><subject>Simulation</subject><issn>0196-6553</issn><issn>1527-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk1uFDEQhVsIRELgAiyQJYTEIjP4p9vTLUVIUcSfFIkFsLY8dnWoSbcdbDdodtyBk3AlTkJ1ZiAoC1Ylub5XLr_nqnos-FJwoV9slnaDbim5qJdcLqncqQ5FI1cLJTt9tzrkotML3TTqoHqQ84Zz3ind3K8OZN2qlRDNYfXzlI3TULAgJPAsl2QLXGxZ7FlG6tiCMTA6xYDh4phdYmEuhhwH9Ne9Y2aDZzCAKykGdMxHN40Qyk6Jmdmco0Ma69k3LJ-ZZXTT5HbtwByxyQ5swAC_vv_4h14PMXraCOxIYA_XkvywutfbIcOjfT2qPr1-9fHs7eL8_Zt3Z6fnC1frrix63do1yLYBa73wvhWrldNKtE0HQgvXy1a7lW7Wqm8V6FZ6qOlo3dX17FOjjqrnu7lXKX6ZIBczYnYwDDZAnLIho7VQtaw5oU9voZs4pUDbEaU4EZprouSOcinmnKA3VwlHm7ZGcDMHajZmDtTMgRouDRUSPdmPntYj-L-SPwkS8GwP2Ozs0CcbHOYbrm20lEoQd7LjgDz7Smmb7BCCA4-JnDU-4v_3eHlL7igwpBsvYQv55r0mk8B8mL_e_PMEuSkUb9VvfmzXvQ</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Allen, Gilman B., MD</creator><creator>Miller, Vincent, MD</creator><creator>Nicholas, Cate, MS, PA, EdD</creator><creator>Hess, Sally, CIC, MPH</creator><creator>Cordes, Mari K., RN, VA-BC</creator><creator>Fortune, John B., MD</creator><creator>Blondin, Joan, RRT, MBA</creator><creator>Ashikaga, Takamaru, PhD</creator><creator>Ricci, Michael, MD</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Mosby-Year Book, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5007-9069</orcidid><orcidid>https://orcid.org/0000-0002-2472-958X</orcidid></search><sort><creationdate>20140601</creationdate><title>A multitiered strategy of simulation training, kit consolidation, and electronic documentation is associated with a reduction in central line–associated bloodstream infections</title><author>Allen, Gilman B., MD ; Miller, Vincent, MD ; Nicholas, Cate, MS, PA, EdD ; Hess, Sally, CIC, MPH ; Cordes, Mari K., RN, VA-BC ; Fortune, John B., MD ; Blondin, Joan, RRT, MBA ; Ashikaga, Takamaru, PhD ; Ricci, Michael, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-f68abe285eaad1dd8177c631859e161cf286c765b3f83e682de4286b944000953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Bacterial diseases</topic><topic>Bacterial infections</topic><topic>Bacterial sepsis</topic><topic>Biological and medical sciences</topic><topic>Blood diseases</topic><topic>Catheter-related bloodstream infection</topic><topic>Catheter-Related Infections - prevention &amp; control</topic><topic>Catheterization, Central Venous - methods</topic><topic>Central Venous Catheters - adverse effects</topic><topic>Compliance</topic><topic>Critical care</topic><topic>Cross Infection - prevention &amp; control</topic><topic>Disease control</topic><topic>Documentation</topic><topic>Electronic Health Records</topic><topic>Electronic monitoring</topic><topic>Epidemiology. Vaccinations</topic><topic>General aspects</topic><topic>Human bacterial diseases</topic><topic>Human infectious diseases. Experimental studies and models</topic><topic>Humans</topic><topic>Infection Control</topic><topic>Infection Control - methods</topic><topic>Infectious Disease</topic><topic>Infectious diseases</topic><topic>Inservice Training</topic><topic>Intensive care</topic><topic>Intensive Care Units - standards</topic><topic>Intensive Care Units - statistics &amp; numerical data</topic><topic>Internship and Residency</topic><topic>Medical sciences</topic><topic>Sepsis - prevention &amp; control</topic><topic>Simulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allen, Gilman B., MD</creatorcontrib><creatorcontrib>Miller, Vincent, MD</creatorcontrib><creatorcontrib>Nicholas, Cate, MS, PA, EdD</creatorcontrib><creatorcontrib>Hess, Sally, CIC, MPH</creatorcontrib><creatorcontrib>Cordes, Mari K., RN, VA-BC</creatorcontrib><creatorcontrib>Fortune, John B., MD</creatorcontrib><creatorcontrib>Blondin, Joan, RRT, MBA</creatorcontrib><creatorcontrib>Ashikaga, Takamaru, PhD</creatorcontrib><creatorcontrib>Ricci, Michael, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of infection control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allen, Gilman B., MD</au><au>Miller, Vincent, MD</au><au>Nicholas, Cate, MS, PA, EdD</au><au>Hess, Sally, CIC, MPH</au><au>Cordes, Mari K., RN, VA-BC</au><au>Fortune, John B., MD</au><au>Blondin, Joan, RRT, MBA</au><au>Ashikaga, Takamaru, PhD</au><au>Ricci, Michael, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A multitiered strategy of simulation training, kit consolidation, and electronic documentation is associated with a reduction in central line–associated bloodstream infections</atitle><jtitle>American journal of infection control</jtitle><addtitle>Am J Infect Control</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>42</volume><issue>6</issue><spage>643</spage><epage>648</epage><pages>643-648</pages><issn>0196-6553</issn><eissn>1527-3296</eissn><abstract>Background Simulation-based training has been associated with reduced central line–associated bloodstream infection (CLABSI) rates. We measured the combined effect of simulation training, electronic medical records (EMR)-based documentation, and standardized kits on CLABSI rates in our medical (MICU) and surgical (SICU) intensive care units (ICU). Methods CLABSI events and catheter-days were collected for 19 months prior to and 37 months following an intervention consisting of simulation training in central line insertion for all ICU residents, incorporation of standardized, all-inclusive catheter kits, and EMR-guided documentation. Supervising physicians in the MICU (but not the SICU) also completed training. Results Following the intervention, EMR-based documentation increased from 48% to 100%, and documented compliance with hand hygiene, barrier precautions, and chlorhexidine use increased from 65%-85% to 100%. CLABSI rate in the MICU dropped from 2.72 per 1,000 catheter-days over the 19 months preceding the intervention to 0.40 per 1,000 over the 37 months following intervention ( P  = .01) but did not change in the SICU (1.09 and 1.14 per 1,000 catheter-days, P  = .86). This equated to 24 fewer than expected CLABSIs and $1,669,000 in estimated savings. Conclusion Combined simulation training, standardized all-inclusive kits, and EMR-guided documentation were associated with greater documented compliance with sterile precautions and reduced CLABSI rate in our MICU. To achieve maximal benefit, refresher training of senior physicians supervising practice at the bedside may be needed.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>24837115</pmid><doi>10.1016/j.ajic.2014.02.014</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5007-9069</orcidid><orcidid>https://orcid.org/0000-0002-2472-958X</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0196-6553
ispartof American journal of infection control, 2014-06, Vol.42 (6), p.643-648
issn 0196-6553
1527-3296
language eng
recordid cdi_proquest_miscellaneous_1526134240
source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Bacterial diseases
Bacterial infections
Bacterial sepsis
Biological and medical sciences
Blood diseases
Catheter-related bloodstream infection
Catheter-Related Infections - prevention & control
Catheterization, Central Venous - methods
Central Venous Catheters - adverse effects
Compliance
Critical care
Cross Infection - prevention & control
Disease control
Documentation
Electronic Health Records
Electronic monitoring
Epidemiology. Vaccinations
General aspects
Human bacterial diseases
Human infectious diseases. Experimental studies and models
Humans
Infection Control
Infection Control - methods
Infectious Disease
Infectious diseases
Inservice Training
Intensive care
Intensive Care Units - standards
Intensive Care Units - statistics & numerical data
Internship and Residency
Medical sciences
Sepsis - prevention & control
Simulation
title A multitiered strategy of simulation training, kit consolidation, and electronic documentation is associated with a reduction in central line–associated bloodstream infections
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T17%3A11%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20multitiered%20strategy%20of%20simulation%20training,%20kit%20consolidation,%20and%20electronic%20documentation%20is%20associated%20with%20a%20reduction%20in%20central%20line%E2%80%93associated%20bloodstream%20infections&rft.jtitle=American%20journal%20of%20infection%20control&rft.au=Allen,%20Gilman%20B.,%20MD&rft.date=2014-06-01&rft.volume=42&rft.issue=6&rft.spage=643&rft.epage=648&rft.pages=643-648&rft.issn=0196-6553&rft.eissn=1527-3296&rft_id=info:doi/10.1016/j.ajic.2014.02.014&rft_dat=%3Cproquest_cross%3E1526134240%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1530403606&rft_id=info:pmid/24837115&rft_els_id=1_s2_0_S0196655314001308&rfr_iscdi=true