Monoamine oxidase A suppresses hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling

Background & Aims Monoamine oxidase A (MAOA), a catecholamine neurotransmitter degrading enzyme, is closely associated with neurological and psychiatric disorders. However, its role in cancer progression remains unknown. Methods Hepatocellular carcinoma (HCC) tissue arrays (n = 254) were used to...

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Veröffentlicht in:	Journal of hepatology 2014-06, Vol.60 (6), p.1225-1234
Hauptverfasser:	Li, Jun, Yang, Xiao-Mei, Wang, Ya-Hui, Feng, Ming-Xuan, Liu, Xiao-Jin, Zhang, Yan-Li, Huang, Shuo, Wu, Zheng, Xue, Feng, Qin, Wen-Xin, Gu, Jian-Ren, Xia, Qiang, Zhang, Zhi-Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-1 Receptor Antagonists - pharmacology Adrenergic alpha-2 Receptor Antagonists - pharmacology Adrenergic receptor Anoikis - drug effects Anoikis - physiology Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - secondary Cell Line, Transformed Cell Line, Tumor EGFR Epinephrine - metabolism Female Gastroenterology and Hepatology Hepatocellular carcinoma Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Metastasis Middle Aged Monoamine Oxidase - genetics Monoamine Oxidase - metabolism Monoamine oxidase A Monoamine Oxidase Inhibitors - pharmacology Norepinephrine - metabolism Predictive Value of Tests Prognosis Receptor, Epidermal Growth Factor - metabolism Receptors, Adrenergic, alpha-1 - metabolism Receptors, Adrenergic, alpha-2 - metabolism Signal Transduction - drug effects Signal Transduction - physiology
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