Detection of donor-specific-antibodies by solid phase assay and its relevance to complement-dependent-lymphocytotoxicity cross-matching in kidney transplantation

Abstract Presensitization against a broad array of HLA is associated with prolonged waiting times and inferior kidney allogaft survival. Although the use of solid phase assay (SPA) for the detection and characterization of anti-HLA antibodies provides greater sensitivity than complement-dependent ly...

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Veröffentlicht in:	Human immunology 2014-06, Vol.75 (6), p.520-523
Hauptverfasser:	Ho, Eric K, Vasilescu, Elena R, Vlad, George, Clynes, Raphael A, Ratner, Lloyd E, Suciu-Foca, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Allergy and Immunology Antilymphocyte Serum - blood B-Lymphocytes - cytology B-Lymphocytes - immunology Complement System Proteins - metabolism Complement-dependent lymphocytotoxicity Cross-matching Donor-specific antibodies Female Gene Expression Graft Rejection - prevention & control Graft Survival Histocompatibility Testing HLA Antigens - genetics HLA Antigens - immunology Humans Immunoassay - methods Isoantibodies - blood Kidney Transplantation Male Middle Aged Solid phase assay T-Lymphocytes - cytology T-Lymphocytes - immunology Tissue Donors Transplantation, Homologous
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