Differential regulation of calcitonin gene-related peptide and substance P in cultured neonatal rat vagal sensory neurons

Nodose (inferior vagal sensory) ganglia were removed from neonatal rats, enzymatically dispersed using neutral protease, and maintained on previously dispersed rat atriacytes. After 7–10 days in culture, calcitonin gene-related peptide (CGRP) was present in 1–3 times the molar amount of substance P...

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Veröffentlicht in:	Brain research 1989-01, Vol.478 (2), p.349-355
Hauptverfasser:	MacLean, David B., Bennett, Barbara, Morris, Mariana, Wheeler, Frances B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Calcitonin Gene-Related Peptide Cell Count Cells, Cultured Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Colforsin - pharmacology Corticosterone - pharmacology Fundamental and applied biological sciences. Psychology Nerve growth factor Nerve Growth Factors - pharmacology Neurons, Afferent - drug effects Neurons, Afferent - metabolism Neuropeptides - metabolism Nodose ganglion Nodose Ganglion - cytology Nodose Ganglion - drug effects Nodose Ganglion - metabolism Phorbol Esters - pharmacology Rats Rats, Inbred Strains Substance P Substance P - metabolism Tissue culture Vagus nerve Vagus Nerve - cytology Vertebrates: nervous system and sense organs
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