Delayed skin wound repair in proline-rich protein tyrosine kinase 2 knockout mice

Proline-rich protein tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family. We used Pyk2 knockout (Pyk2-KO) mice to study the role of Pyk2 in cutaneous wound repair. We report that the rate of wound closure was delayed in Pyk2-KO compared with control mice. To examine whether impa...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2014-05, Vol.306 (10), p.C899-C909
Hauptverfasser:	Koppel, Aaron C, Kiss, Alexi, Hindes, Anna, Burns, Carole J, Marmer, Barry L, Goldberg, Gregory, Blumenberg, Miroslav, Efimova, Tatiana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement - drug effects Cells Cells, Cultured Dipeptides - pharmacology Focal Adhesion Kinase 2 - deficiency Focal Adhesion Kinase 2 - genetics Gene Expression Regulation Genes, Dominant Humans Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - metabolism Kinases Male Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase 10 - genetics Matrix Metalloproteinase 10 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors - pharmacology Mice Mice, Knockout Protein expression Protein Kinase C-delta - genetics Protein Kinase C-delta - metabolism Re-Epithelialization - genetics Rodents Signal Transduction Skin Skin - drug effects Skin - injuries Skin - metabolism Wound healing
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