Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity

Glycerol-3-phosphate acyltransferases (GPATs) catalyze the first step in the synthesis of glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is encoded by at least two closely related genes, GPAT3 and GPAT4. To investigate the in vivo functions of GPAT3, we generated G...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2014-05, Vol.306 (10), p.E1176-E1187
Hauptverfasser:	Cao, Jingsong, Perez, Sylvie, Goodwin, Bryan, Lin, Qingcong, Peng, Haibing, Qadri, Ariful, Zhou, Yingjiang, Clark, Ronald W, Perreault, Mylene, Tobin, James F, Gimeno, Ruth E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, White - enzymology Animals Cholesterol - metabolism Diet - adverse effects Energy Metabolism - genetics Female Glucose Glycerol Glycerol-3-Phosphate O-Acyltransferase - genetics Glycerol-3-Phosphate O-Acyltransferase - metabolism Homeostasis Homeostasis - genetics Lipid Metabolism - genetics Lipids Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout Obesity - enzymology Obesity - genetics Rodents Tissues
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