Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease MRL-Fas(lpr) mice

The T-cell immunoglobulin mucin 1, also known as kidney injury molecule-1, modulates CD4+ T-cell responses and is also expressed by damaged proximal tubules within the kidney. Both Th subset imbalance (Th1/Th2/Th17) and regulatory T-cell and B-cell alterations contribute to the pathogenesis of autoi...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2014-05, Vol.306 (10), p.F1210-F1221
Hauptverfasser:	Nozaki, Yuji, Kitching, A Richard, Akiba, Hisaya, Yagita, Hideo, Kinoshita, Koji, Funauchi, Masanori, Matsumura, Itaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Anti-Idiotypic - immunology Antibodies, Anti-Idiotypic - pharmacology Apoptosis - drug effects Autoimmune Diseases - epidemiology Autoimmune Diseases - physiopathology Cell Proliferation - drug effects Disease Models, Animal Female Hepatitis A Virus Cellular Receptor 1 Kidney - pathology Kidney Diseases - epidemiology Kidney Diseases - physiopathology Lupus Erythematosus, Systemic - physiopathology Membrane Proteins - antagonists & inhibitors Membrane Proteins - immunology Membrane Proteins - physiology Mice Mice, Inbred MRL lpr Proteinuria - prevention & control Severity of Illness Index
Online-Zugang:	Volltext
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