Experimental Study of the Effects of Sodium Ion Concentrations on the Function of the Myocardium Exposed to Cardioplegic Ischemia
A new cardioplegic solution based on three natural dipeptides was developed and introduced at the Laboratory of Cardioplegia, A. N. Bakulev Research Center of Cardiovascular Surgery. The electrolyte composition of the solution corresponded to the category of intracellular cardioplegic solutions. The...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2014-04, Vol.156 (6), p.880-884 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Bokeriya, L. A. Boldyrev, A. A. Movsesyan, R. R. Kulaga, O. I. Bledzhyants, G. A. Egorov, D. N. Popov, A. E. Plyushch, M. G. Kozar, E. F. Kalaeva, N. V. |
| description | A new cardioplegic solution based on three natural dipeptides was developed and introduced at the Laboratory of Cardioplegia, A. N. Bakulev Research Center of Cardiovascular Surgery. The electrolyte composition of the solution corresponded to the category of intracellular cardioplegic solutions. The results of 60 experiments on isolated rat hearts were analyzed for choosing the optimal concentration of sodium ions (35, 60, or 80 mmol/liter). The composition of the studied cardioplegic solutions was selected by ion concentrations in the intra- and extracellular fluid. Earlier and most effective recovery of cardiac function with minimum rhythm and conductivity disorders was observed in the group treated with cardioplegic solution with sodium ion concentration of 60 mmol/liter. |
| doi_str_mv | 10.1007/s10517-014-2474-4 |
| format | Article |
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A. ; Boldyrev, A. A. ; Movsesyan, R. R. ; Kulaga, O. I. ; Bledzhyants, G. A. ; Egorov, D. N. ; Popov, A. E. ; Plyushch, M. G. ; Kozar, E. F. ; Kalaeva, N. V.</creator><creatorcontrib>Bokeriya, L. A. ; Boldyrev, A. A. ; Movsesyan, R. R. ; Kulaga, O. I. ; Bledzhyants, G. A. ; Egorov, D. N. ; Popov, A. E. ; Plyushch, M. G. ; Kozar, E. F. ; Kalaeva, N. V.</creatorcontrib><description>A new cardioplegic solution based on three natural dipeptides was developed and introduced at the Laboratory of Cardioplegia, A. N. Bakulev Research Center of Cardiovascular Surgery. The electrolyte composition of the solution corresponded to the category of intracellular cardioplegic solutions. The results of 60 experiments on isolated rat hearts were analyzed for choosing the optimal concentration of sodium ions (35, 60, or 80 mmol/liter). The composition of the studied cardioplegic solutions was selected by ion concentrations in the intra- and extracellular fluid. Earlier and most effective recovery of cardiac function with minimum rhythm and conductivity disorders was observed in the group treated with cardioplegic solution with sodium ion concentration of 60 mmol/liter.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-014-2474-4</identifier><identifier>PMID: 24824721</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Dose-Response Relationship, Drug ; Extracellular Fluid - chemistry ; Heart Arrest, Induced ; Internal Medicine ; Ischemia ; Ischemia - physiopathology ; Laboratory Medicine ; Male ; Methods ; Myocardium - metabolism ; Pathology ; Rats ; Rats, Wistar ; Sodium - administration & dosage ; Sodium - pharmacology</subject><ispartof>Bulletin of experimental biology and medicine, 2014-04, Vol.156 (6), p.880-884</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c422t-e3a9037db1440d9ba05ba4d5ddc588f64bafe67b2af92755706b3730cfa4d1833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-014-2474-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-014-2474-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24824721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bokeriya, L. 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A.</au><au>Boldyrev, A. A.</au><au>Movsesyan, R. R.</au><au>Kulaga, O. I.</au><au>Bledzhyants, G. A.</au><au>Egorov, D. N.</au><au>Popov, A. E.</au><au>Plyushch, M. G.</au><au>Kozar, E. F.</au><au>Kalaeva, N. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Study of the Effects of Sodium Ion Concentrations on the Function of the Myocardium Exposed to Cardioplegic Ischemia</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>156</volume><issue>6</issue><spage>880</spage><epage>884</epage><pages>880-884</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>A new cardioplegic solution based on three natural dipeptides was developed and introduced at the Laboratory of Cardioplegia, A. N. Bakulev Research Center of Cardiovascular Surgery. The electrolyte composition of the solution corresponded to the category of intracellular cardioplegic solutions. The results of 60 experiments on isolated rat hearts were analyzed for choosing the optimal concentration of sodium ions (35, 60, or 80 mmol/liter). The composition of the studied cardioplegic solutions was selected by ion concentrations in the intra- and extracellular fluid. Earlier and most effective recovery of cardiac function with minimum rhythm and conductivity disorders was observed in the group treated with cardioplegic solution with sodium ion concentration of 60 mmol/liter.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24824721</pmid><doi>10.1007/s10517-014-2474-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | Bulletin of experimental biology and medicine, 2014-04, Vol.156 (6), p.880-884 |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Cell Biology Dose-Response Relationship, Drug Extracellular Fluid - chemistry Heart Arrest, Induced Internal Medicine Ischemia Ischemia - physiopathology Laboratory Medicine Male Methods Myocardium - metabolism Pathology Rats Rats, Wistar Sodium - administration & dosage Sodium - pharmacology |
| title | Experimental Study of the Effects of Sodium Ion Concentrations on the Function of the Myocardium Exposed to Cardioplegic Ischemia |
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