Effects of phenylephrine and noradrenaline on coronary artery motion in an open-chest porcine beating heart model
Purpose During off-pump coronary artery bypass (OPCAB), surgeons are required to perform a precise anastomosis on the beating heart. The hypotension caused by vertical displacement of the heart during OPCAB is usually treated with vasopressors, such as noradrenaline and phenylephrine. However, the e...
Gespeichert in:
| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2014-06, Vol.44 (6), p.1128-1137 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1137 |
|---|---|
| container_issue | 6 |
| container_start_page | 1128 |
| container_title | Surgery today (Tokyo, Japan) |
| container_volume | 44 |
| creator | Kurosawa, Hiroyuki Seto, Yuki Wakamatsu, Hiroki Sato, Yoshiyuki Takase, Shinya Omata, Sadao Yokoyama, Hitoshi |
| description | Purpose
During off-pump coronary artery bypass (OPCAB), surgeons are required to perform a precise anastomosis on the beating heart. The hypotension caused by vertical displacement of the heart during OPCAB is usually treated with vasopressors, such as noradrenaline and phenylephrine. However, the effects of these agents on coronary artery motion are unknown. The present study analyzed the motion of the target coronary arteries during noradrenaline or phenylephrine infusion using three-dimensional motion capture and reconstruction technology.
Methods
The left anterior descending (LAD) artery, left circumflex (LCX) artery and right coronary artery (RCA) of 12 female landrace pigs (weight 50 ± 1 kg) were stabilized using a tissue stabilizer. The motions in the regions were captured before and during noradrenaline (
n
= 5) and phenylephrine (
n
= 7) infusion.
Results
Noradrenaline (0.15 μg/kg/min) and phenylephrine (1.1 μg/kg/min) significantly increased the blood pressure. Noradrenaline significantly increased the motion parameters, such as the distance moved, maximum velocity, acceleration and deceleration at the LAD (4.2 vs. 7.9 mm,
P
= 0.025; 95.7 vs. 215.5 mm/s,
P
= 0.0074; 35.3 vs. 83.6 m/s
2
,
P
= 0.0096 and −35.6 vs. −83.6 m/s
2
,
P
= 0.005, respectively). The values during phenylephrine infusion did not change except for the distance moved at the LAD (3.8 vs. 7.7 mm,
P
= 0.042). The motion parameters at the LCX and RCA during noradrenaline and phenylephrine infusion did not change significantly.
Conclusions
The effect of phenylephrine on the coronary artery motion was less dramatic than that of noradrenaline. |
| doi_str_mv | 10.1007/s00595-013-0639-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1524817585</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1524817585</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-62e38a6fd1b7d185f13b49c14ff6327c758ba9e279e8448db8f0b9fc3f24d7ca3</originalsourceid><addsrcrecordid>eNp9kMtOBCEQRYnR6Pj4ADeGpRuUgn7A0hhfiYkbXROaLmZ60gMt9Cz8e5mMunRVSXHuDXUIuQR-A5y3t5nzWteMg2S8kZrpA7KASjZMKJCHZMF1BQyEhhNymvOac1Epzo_JiZAKhNJ6QT4fvEc3Zxo9nVYYvkacVmkISG3oaYjJ9gmDHXebGKiLKQabvqhNM5axifNQ1kMoOI0TBuZWmGc6xeR2kQ7tPIQlXWEJFLrH8ZwceTtmvPiZZ-Tj8eH9_pm9vj293N-9MicbNbNGoFS28T10bQ-q9iC7SjuovG-kaF1bq85qFK1GVVWq75TnnfZOelH1rbPyjFzve6cUP7flU2YzZIfjaAPGbTZQFxtQauqCwh51Keac0JspDZtypgFudqbN3rQpps3OtNElc_VTv-022P8lftUWQOyBXJ7CEpNZx20qKvM_rd_cGosq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1524817585</pqid></control><display><type>article</type><title>Effects of phenylephrine and noradrenaline on coronary artery motion in an open-chest porcine beating heart model</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kurosawa, Hiroyuki ; Seto, Yuki ; Wakamatsu, Hiroki ; Sato, Yoshiyuki ; Takase, Shinya ; Omata, Sadao ; Yokoyama, Hitoshi</creator><creatorcontrib>Kurosawa, Hiroyuki ; Seto, Yuki ; Wakamatsu, Hiroki ; Sato, Yoshiyuki ; Takase, Shinya ; Omata, Sadao ; Yokoyama, Hitoshi</creatorcontrib><description>Purpose
During off-pump coronary artery bypass (OPCAB), surgeons are required to perform a precise anastomosis on the beating heart. The hypotension caused by vertical displacement of the heart during OPCAB is usually treated with vasopressors, such as noradrenaline and phenylephrine. However, the effects of these agents on coronary artery motion are unknown. The present study analyzed the motion of the target coronary arteries during noradrenaline or phenylephrine infusion using three-dimensional motion capture and reconstruction technology.
Methods
The left anterior descending (LAD) artery, left circumflex (LCX) artery and right coronary artery (RCA) of 12 female landrace pigs (weight 50 ± 1 kg) were stabilized using a tissue stabilizer. The motions in the regions were captured before and during noradrenaline (
n
= 5) and phenylephrine (
n
= 7) infusion.
Results
Noradrenaline (0.15 μg/kg/min) and phenylephrine (1.1 μg/kg/min) significantly increased the blood pressure. Noradrenaline significantly increased the motion parameters, such as the distance moved, maximum velocity, acceleration and deceleration at the LAD (4.2 vs. 7.9 mm,
P
= 0.025; 95.7 vs. 215.5 mm/s,
P
= 0.0074; 35.3 vs. 83.6 m/s
2
,
P
= 0.0096 and −35.6 vs. −83.6 m/s
2
,
P
= 0.005, respectively). The values during phenylephrine infusion did not change except for the distance moved at the LAD (3.8 vs. 7.7 mm,
P
= 0.042). The motion parameters at the LCX and RCA during noradrenaline and phenylephrine infusion did not change significantly.
Conclusions
The effect of phenylephrine on the coronary artery motion was less dramatic than that of noradrenaline.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-013-0639-9</identifier><identifier>PMID: 23812899</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Animals ; Coronary Artery Bypass, Off-Pump ; Coronary Vessels - drug effects ; Coronary Vessels - physiology ; Female ; Hemodynamics - drug effects ; Image Processing, Computer-Assisted - methods ; Imaging, Three-Dimensional - methods ; Medicine ; Medicine & Public Health ; Models, Animal ; Motion ; Norepinephrine - pharmacology ; Original Article ; Phenylephrine - pharmacology ; Surgery ; Surgical Oncology ; Swine ; Vasoconstrictor Agents - pharmacology</subject><ispartof>Surgery today (Tokyo, Japan), 2014-06, Vol.44 (6), p.1128-1137</ispartof><rights>Springer Japan 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-62e38a6fd1b7d185f13b49c14ff6327c758ba9e279e8448db8f0b9fc3f24d7ca3</citedby><cites>FETCH-LOGICAL-c368t-62e38a6fd1b7d185f13b49c14ff6327c758ba9e279e8448db8f0b9fc3f24d7ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-013-0639-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-013-0639-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23812899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurosawa, Hiroyuki</creatorcontrib><creatorcontrib>Seto, Yuki</creatorcontrib><creatorcontrib>Wakamatsu, Hiroki</creatorcontrib><creatorcontrib>Sato, Yoshiyuki</creatorcontrib><creatorcontrib>Takase, Shinya</creatorcontrib><creatorcontrib>Omata, Sadao</creatorcontrib><creatorcontrib>Yokoyama, Hitoshi</creatorcontrib><title>Effects of phenylephrine and noradrenaline on coronary artery motion in an open-chest porcine beating heart model</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose
During off-pump coronary artery bypass (OPCAB), surgeons are required to perform a precise anastomosis on the beating heart. The hypotension caused by vertical displacement of the heart during OPCAB is usually treated with vasopressors, such as noradrenaline and phenylephrine. However, the effects of these agents on coronary artery motion are unknown. The present study analyzed the motion of the target coronary arteries during noradrenaline or phenylephrine infusion using three-dimensional motion capture and reconstruction technology.
Methods
The left anterior descending (LAD) artery, left circumflex (LCX) artery and right coronary artery (RCA) of 12 female landrace pigs (weight 50 ± 1 kg) were stabilized using a tissue stabilizer. The motions in the regions were captured before and during noradrenaline (
n
= 5) and phenylephrine (
n
= 7) infusion.
Results
Noradrenaline (0.15 μg/kg/min) and phenylephrine (1.1 μg/kg/min) significantly increased the blood pressure. Noradrenaline significantly increased the motion parameters, such as the distance moved, maximum velocity, acceleration and deceleration at the LAD (4.2 vs. 7.9 mm,
P
= 0.025; 95.7 vs. 215.5 mm/s,
P
= 0.0074; 35.3 vs. 83.6 m/s
2
,
P
= 0.0096 and −35.6 vs. −83.6 m/s
2
,
P
= 0.005, respectively). The values during phenylephrine infusion did not change except for the distance moved at the LAD (3.8 vs. 7.7 mm,
P
= 0.042). The motion parameters at the LCX and RCA during noradrenaline and phenylephrine infusion did not change significantly.
Conclusions
The effect of phenylephrine on the coronary artery motion was less dramatic than that of noradrenaline.</description><subject>Animals</subject><subject>Coronary Artery Bypass, Off-Pump</subject><subject>Coronary Vessels - drug effects</subject><subject>Coronary Vessels - physiology</subject><subject>Female</subject><subject>Hemodynamics - drug effects</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Models, Animal</subject><subject>Motion</subject><subject>Norepinephrine - pharmacology</subject><subject>Original Article</subject><subject>Phenylephrine - pharmacology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Swine</subject><subject>Vasoconstrictor Agents - pharmacology</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOBCEQRYnR6Pj4ADeGpRuUgn7A0hhfiYkbXROaLmZ60gMt9Cz8e5mMunRVSXHuDXUIuQR-A5y3t5nzWteMg2S8kZrpA7KASjZMKJCHZMF1BQyEhhNymvOac1Epzo_JiZAKhNJ6QT4fvEc3Zxo9nVYYvkacVmkISG3oaYjJ9gmDHXebGKiLKQabvqhNM5axifNQ1kMoOI0TBuZWmGc6xeR2kQ7tPIQlXWEJFLrH8ZwceTtmvPiZZ-Tj8eH9_pm9vj293N-9MicbNbNGoFS28T10bQ-q9iC7SjuovG-kaF1bq85qFK1GVVWq75TnnfZOelH1rbPyjFzve6cUP7flU2YzZIfjaAPGbTZQFxtQauqCwh51Keac0JspDZtypgFudqbN3rQpps3OtNElc_VTv-022P8lftUWQOyBXJ7CEpNZx20qKvM_rd_cGosq</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Kurosawa, Hiroyuki</creator><creator>Seto, Yuki</creator><creator>Wakamatsu, Hiroki</creator><creator>Sato, Yoshiyuki</creator><creator>Takase, Shinya</creator><creator>Omata, Sadao</creator><creator>Yokoyama, Hitoshi</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Effects of phenylephrine and noradrenaline on coronary artery motion in an open-chest porcine beating heart model</title><author>Kurosawa, Hiroyuki ; Seto, Yuki ; Wakamatsu, Hiroki ; Sato, Yoshiyuki ; Takase, Shinya ; Omata, Sadao ; Yokoyama, Hitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-62e38a6fd1b7d185f13b49c14ff6327c758ba9e279e8448db8f0b9fc3f24d7ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Coronary Artery Bypass, Off-Pump</topic><topic>Coronary Vessels - drug effects</topic><topic>Coronary Vessels - physiology</topic><topic>Female</topic><topic>Hemodynamics - drug effects</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Models, Animal</topic><topic>Motion</topic><topic>Norepinephrine - pharmacology</topic><topic>Original Article</topic><topic>Phenylephrine - pharmacology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Swine</topic><topic>Vasoconstrictor Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurosawa, Hiroyuki</creatorcontrib><creatorcontrib>Seto, Yuki</creatorcontrib><creatorcontrib>Wakamatsu, Hiroki</creatorcontrib><creatorcontrib>Sato, Yoshiyuki</creatorcontrib><creatorcontrib>Takase, Shinya</creatorcontrib><creatorcontrib>Omata, Sadao</creatorcontrib><creatorcontrib>Yokoyama, Hitoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurosawa, Hiroyuki</au><au>Seto, Yuki</au><au>Wakamatsu, Hiroki</au><au>Sato, Yoshiyuki</au><au>Takase, Shinya</au><au>Omata, Sadao</au><au>Yokoyama, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of phenylephrine and noradrenaline on coronary artery motion in an open-chest porcine beating heart model</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>44</volume><issue>6</issue><spage>1128</spage><epage>1137</epage><pages>1128-1137</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Purpose
During off-pump coronary artery bypass (OPCAB), surgeons are required to perform a precise anastomosis on the beating heart. The hypotension caused by vertical displacement of the heart during OPCAB is usually treated with vasopressors, such as noradrenaline and phenylephrine. However, the effects of these agents on coronary artery motion are unknown. The present study analyzed the motion of the target coronary arteries during noradrenaline or phenylephrine infusion using three-dimensional motion capture and reconstruction technology.
Methods
The left anterior descending (LAD) artery, left circumflex (LCX) artery and right coronary artery (RCA) of 12 female landrace pigs (weight 50 ± 1 kg) were stabilized using a tissue stabilizer. The motions in the regions were captured before and during noradrenaline (
n
= 5) and phenylephrine (
n
= 7) infusion.
Results
Noradrenaline (0.15 μg/kg/min) and phenylephrine (1.1 μg/kg/min) significantly increased the blood pressure. Noradrenaline significantly increased the motion parameters, such as the distance moved, maximum velocity, acceleration and deceleration at the LAD (4.2 vs. 7.9 mm,
P
= 0.025; 95.7 vs. 215.5 mm/s,
P
= 0.0074; 35.3 vs. 83.6 m/s
2
,
P
= 0.0096 and −35.6 vs. −83.6 m/s
2
,
P
= 0.005, respectively). The values during phenylephrine infusion did not change except for the distance moved at the LAD (3.8 vs. 7.7 mm,
P
= 0.042). The motion parameters at the LCX and RCA during noradrenaline and phenylephrine infusion did not change significantly.
Conclusions
The effect of phenylephrine on the coronary artery motion was less dramatic than that of noradrenaline.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>23812899</pmid><doi>10.1007/s00595-013-0639-9</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-1291 |
| ispartof | Surgery today (Tokyo, Japan), 2014-06, Vol.44 (6), p.1128-1137 |
| issn | 0941-1291 1436-2813 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1524817585 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Coronary Artery Bypass, Off-Pump Coronary Vessels - drug effects Coronary Vessels - physiology Female Hemodynamics - drug effects Image Processing, Computer-Assisted - methods Imaging, Three-Dimensional - methods Medicine Medicine & Public Health Models, Animal Motion Norepinephrine - pharmacology Original Article Phenylephrine - pharmacology Surgery Surgical Oncology Swine Vasoconstrictor Agents - pharmacology |
| title | Effects of phenylephrine and noradrenaline on coronary artery motion in an open-chest porcine beating heart model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T12%3A47%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20phenylephrine%20and%20noradrenaline%20on%20coronary%20artery%20motion%20in%20an%20open-chest%20porcine%20beating%20heart%20model&rft.jtitle=Surgery%20today%20(Tokyo,%20Japan)&rft.au=Kurosawa,%20Hiroyuki&rft.date=2014-06-01&rft.volume=44&rft.issue=6&rft.spage=1128&rft.epage=1137&rft.pages=1128-1137&rft.issn=0941-1291&rft.eissn=1436-2813&rft_id=info:doi/10.1007/s00595-013-0639-9&rft_dat=%3Cproquest_cross%3E1524817585%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1524817585&rft_id=info:pmid/23812899&rfr_iscdi=true |