Autophagy enhances hepatocellular carcinoma progression by activation of mitochondrial β-oxidation

Background Several types of cancers, including hepatocellular carcinoma (HCC), show resistance to hypoxia and nutrient starvation. Autophagy is a means of providing macromolecules for energy generation under such stressed-conditions. The aim of this study was to clarify the role of autophagy in HCC...

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Veröffentlicht in:	Journal of gastroenterology 2014-05, Vol.49 (5), p.907-916
Hauptverfasser:	Toshima, Takeo, Shirabe, Ken, Matsumoto, Yoshihiro, Yoshiya, Shohei, Ikegami, Toru, Yoshizumi, Tomoharu, Soejima, Yuji, Ikeda, Tetsuo, Maehara, Yoshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Adenosine Triphosphate - metabolism Autophagy Biliary Tract Blotting, Western Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Hypoxia Cell Line, Tumor Cell Proliferation - physiology Cell Survival - physiology Colorectal Surgery Disease Progression Gastroenterology Hepatology Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Liver Neoplasms - genetics Liver Neoplasms - pathology Medicine Medicine & Public Health Microtubule-Associated Proteins - genetics Mitochondria - metabolism Original Article—Liver Oxidation-Reduction Pancreas Real-Time Polymerase Chain Reaction Surgical Oncology
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