β‑Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T‑Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis

β-Lactam antibiotics provide the cornerstone of treatment for respiratory exacerbations in patients with cystic fibrosis. Unfortunately, approximately 20% of patients develop multiple nonimmediate allergic reactions that restrict therapeutic options. The purpose of this study was to explore the chem...

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Veröffentlicht in:Chemical research in toxicology 2013-06, Vol.26 (6), p.963-975
Hauptverfasser: Jenkins, Rosalind E, Yaseen, Fiazia S, Monshi, Manal M, Whitaker, Paul, Meng, Xiaoli, Farrell, John, Hamlett, Jane, Sanderson, Joseph P, El-Ghaiesh, Sabah, Peckham, Daniel, Pirmohamed, Munir, Park, B. Kevin, Naisbitt, Dean J
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Sprache:eng
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