Chemical Reactivity and Skin Sensitization Potential for Benzaldehydes: Can Schiff Base Formation Explain Everything?

Skin sensitizers chemically modify skin proteins rendering them immunogenic. Sensitizing chemicals have been divided into applicability domains according to their suspected reaction mechanism. The widely accepted Schiff base applicability domain covers aldehydes and ketones, and detailed structure–a...

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Veröffentlicht in:	Chemical research in toxicology 2012-10, Vol.25 (10), p.2203-2215
Hauptverfasser:	Natsch, Andreas, Gfeller, Hans, Haupt, Tina, Brunner, Gerhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - chemistry Allergens - immunology Benzaldehydes - chemistry Benzaldehydes - immunology Butylamines - chemistry Butylamines - immunology Humans Peptides - chemistry Peptides - immunology Schiff Bases - chemistry Schiff Bases - immunology Skin - drug effects Skin - immunology
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