PDGFs and PDGFRs in canine osteosarcoma: New targets for innovative therapeutic strategies in comparative oncology

Platelet derived growth factor receptor (PDGFR)α and PDGFRβ are tyrosine kinase receptors that are overexpressed in 70–80% of human osteosarcomas (OSAs) and may be suitable therapeutic targets for specific kinase inhibitors (TKIs). Canine OSA shows histopathological and clinical features similar to...

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Veröffentlicht in:	The veterinary journal (1997) 2013-01, Vol.195 (1), p.41-47
Hauptverfasser:	Maniscalco, Lorella, Iussich, Selina, Morello, Emanuela, Martano, Marina, Biolatti, Bartolomeo, Riondato, Fulvio, Salda, Leonardo Della, Romanucci, Mariarita, Malatesta, Daniela, Bongiovanni, Laura, Tirrito, Federica, Gattino, Francesca, Buracco, Paolo, De Maria, Raffaella
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Biomarkers, Tumor Canine osteosarcoma Cell Line, Tumor Comparative oncology Dog Diseases - genetics Dog Diseases - metabolism Dogs etiology Gene Expression Regulation, Neoplastic gene overexpression histopathology humans immunohistochemistry osteosarcoma Osteosarcoma - metabolism Osteosarcoma - veterinary PDGF PDGF receptor phosphorylation Platelet-Derived Growth Factor - genetics Platelet-Derived Growth Factor - metabolism quantitative polymerase chain reaction receptors Receptors, Platelet-Derived Growth Factor - genetics Receptors, Platelet-Derived Growth Factor - metabolism Targeted therapy Western blotting
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