Transport of Chlorpromazine in the Caco-2 Cell Permeability Assay: A Kinetic Study

The intestinal transport of compounds can be measured in vitro with Caco-2 cell monolayers. We took a closer look at the exposure and fate of a chemical in the Caco-2 cell assay, including the effect of protein binding. Transport of chlorpromazine (CPZ) was measured in the absorptive and secretory d...

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Veröffentlicht in:	Chemical research in toxicology 2012-07, Vol.25 (7), p.1442-1451
Hauptverfasser:	Broeders, Jessica J. W, van Eijkeren, Jan C. H, Blaauboer, Bas J, Hermens, Joop L. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Biological Transport - drug effects Caco-2 Cells Cell Membrane Permeability - drug effects Chlorpromazine - chemistry Chlorpromazine - pharmacology Humans Hydrophobic and Hydrophilic Interactions Kinetics Serum Albumin - metabolism Solid Phase Microextraction
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