p53 inactivation decreases dependence on estrogen/ERK signalling for proliferation but promotes EMT and susceptility to 3-bromopyruvate in ERα+ breast cancer MCF-7 cells

Most breast cancers express the estrogen receptor alpha (ERα+), harbor wt TP53, depend on estrogen/ERK signalling for proliferation, and respond to anti-estrogens. However, concomittant activation of the epidermal growth factor receptor (EGFR)/MEK pathway promotes resistance by decreasing estrogen d...

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Veröffentlicht in:	Biochemical pharmacology 2014-03, Vol.88 (2), p.169-177
Hauptverfasser:	Rieber, Manuel, Strasberg-Rieber, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Bromopyruvate Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Proliferation - drug effects Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - physiology Epithelial–mesenchymal transition Estrogen hypersensitivity Estrogen Receptor alpha - biosynthesis Female Genes, p53 - drug effects Genes, p53 - physiology Humans MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology MCF-7 Cells MEK inhibition Pyruvate Dehydrogenase Complex - antagonists & inhibitors Pyruvate Dehydrogenase Complex - metabolism Pyruvates - pharmacology Pyruvates - therapeutic use
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