Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages

Aspirin gained tremendous popularity during the 1918 Spanish Influenza virus pandemic, 50 years prior to the demonstration of their inhibitory action on prostaglandins. Here, we show that during influenza A virus (IAV) infection, prostaglandin E2 (PGE2) was upregulated, which led to the inhibition o...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2014-04, Vol.40 (4), p.554-568
Hauptverfasser:	Coulombe, François, Jaworska, Joanna, Verway, Mark, Tzelepis, Fanny, Massoud, Amir, Gillard, Joshua, Wong, Gary, Kobinger, Gary, Xing, Zhou, Couture, Christian, Joubert, Philippe, Fritz, Jörg H., Powell, William S., Divangahi, Maziar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation - drug effects Apoptosis - drug effects Cells, Cultured Dinoprostone - immunology Dinoprostone - metabolism Gene Expression Regulation - drug effects Immunity - drug effects Immunity - genetics Influenza A virus Influenza A virus - physiology Interferon Type I - genetics Interferon Type I - metabolism Intramolecular Oxidoreductases - antagonists & inhibitors Intramolecular Oxidoreductases - genetics Macrophages - drug effects Macrophages - immunology Macrophages - virology Mice Mice, Inbred C57BL Mice, Knockout Molecular Targeted Therapy Orthomyxoviridae Infections - drug therapy Orthomyxoviridae Infections - immunology Prostaglandin-E Synthases Receptors, Prostaglandin E, EP2 Subtype - antagonists & inhibitors Receptors, Prostaglandin E, EP4 Subtype - antagonists & inhibitors T-Lymphocytes - immunology T-Lymphocytes - virology Virus Replication - genetics
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