Bone Environment is Essential for Osteosarcoma Development from Transformed Mesenchymal Stem Cells

The cellular microenvironment plays a relevant role in cancer development. We have reported that mesenchymal stromal/stem cells (MSCs) deficient for p53 alone or together with RB (p53−/−RB−/−) originate leiomyosarcoma after subcutaneous (s.c.) inoculation. Here, we show that intrabone or periosteal...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2014-05, Vol.32 (5), p.1136-1148
Hauptverfasser:	Rubio, Ruth, Abarrategi, Ander, Garcia‐Castro, Javier, Martinez‐Cruzado, Lucia, Suarez, Carlos, Tornin, Juan, Santos, Laura, Astudillo, Aurora, Colmenero, Isabel, Mulero, Francisca, Rosu‐Myles, Michael, Menendez, Pablo, Rodriguez, Rene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Bone Bone and Bones - drug effects Bone and Bones - metabolism Bone and Bones - pathology Bone marrow Bone Morphogenetic Protein 2 - pharmacology Bone morphogenetic protein‐2 Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Calcium Phosphates - chemistry Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cells, Cultured Cellular Microenvironment Ceramics - chemistry Durapatite - chemistry Humans Immunization Interleukin Receptor Common gamma Subunit - deficiency Interleukin Receptor Common gamma Subunit - genetics Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Mice, Inbred NOD Mice, Knockout Mice, SCID Osteogenesis - drug effects Osteogenesis - genetics Osteosarcoma Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology p53 Retinoblastoma Protein - deficiency Retinoblastoma Protein - genetics Reverse Transcriptase Polymerase Chain Reaction Stem cells Tissue Scaffolds - chemistry Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics Tumoral microenvironment WNT signaling
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!