Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

A screen for compounds that may inhibit the growth of hematological malignancies reveals the specific dependence of some mantle cell lymphoma (MCL) cell lines on canonical or alternative NF-κB signaling. As also seen in patients, genetic alterations affecting alternative NF-κB signaling confer insen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature medicine 2014-01, Vol.20 (1), p.87-92
Hauptverfasser: Rahal, Rami, Frick, Mareike, Romero, Rodrigo, Korn, Joshua M, Kridel, Robert, Chun Chan, Fong, Meissner, Barbara, Bhang, Hyo-eun, Ruddy, Dave, Kauffmann, Audrey, Farsidjani, Ali, Derti, Adnan, Rakiec, Daniel, Naylor, Tara, Pfister, Estelle, Kovats, Steve, Kim, Sunkyu, Dietze, Kerstin, Dörken, Bernd, Steidl, Christian, Tzankov, Alexandar, Hummel, Michael, Monahan, John, Morrissey, Michael P, Fritsch, Christine, Sellers, William R, Cooke, Vesselina G, Gascoyne, Randy D, Lenz, Georg, Stegmeier, Frank
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!