Prognostic significance of whole-body MRI in patients with monoclonal gammopathy of undetermined significance
Radiological skeletal survey or computed tomography are currently applied to assess bone diseases in patients with monoclonal plasma cell disorders. Whole-body magnetic resonance imaging (whole-body MRI) allows detecting the infiltration of clonal cells in nearly the whole bone marrow compartment ev...
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| Veröffentlicht in: | Leukemia 2014-01, Vol.28 (1), p.174-178 |
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| creator | Hillengass, J Weber, M-A Kilk, K Listl, K Wagner-Gund, B Hillengass, M Hielscher, T Farid, A Neben, K Delorme, S Landgren, O Goldschmidt, H |
| description | Radiological skeletal survey or computed tomography are currently applied to assess bone diseases in patients with monoclonal plasma cell disorders. Whole-body magnetic resonance imaging (whole-body MRI) allows detecting the infiltration of clonal cells in nearly the whole bone marrow compartment even before bone destruction has occurred. Those MRI results (i.e., patterns of bone marrow infiltration) have been demonstrated to be of prognostic significance in patients with symptomatic as well as asymptomatic multiple myeloma. We have therefore analyzed the findings of whole-body MRI in 137 consecutive individuals with monoclonal gammopathy of undetermined significance (MGUS). A focal infiltration pattern was detected in 23.4% of patients. Presence and number of focal lesions as well as value of M-Protein were of independent prognostic significance for progression into a symptomatic disease requiring systemic treatment (
P
=0.02;
P |
| doi_str_mv | 10.1038/leu.2013.244 |
| format | Article |
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P
=0.02;
P
<0.0001 and
P
=0.0005, respectively). Lower homogeneous signal intensities in T1-weighted images were related to a physiologically higher bone marrow cellularity in younger individuals (
P
=0.002). We conclude that whole-body MRI identifies patients with focal accumulations of presumably monoclonal cells in bone marrow with prognostic impact concerning the risk of progression into symptomatic disease.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/leu.2013.244</identifier><identifier>PMID: 23958921</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/249/1573 ; 692/699/67/1990/804 ; 692/700/1421/1628 ; 692/700/1750 ; Asymptomatic ; Bone marrow ; Cancer Research ; Critical Care Medicine ; Disease ; Hematology ; Humans ; Immunoglobulins ; Immunologic diseases ; Intensive ; Internal Medicine ; Leukemia ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medical prognosis ; Medical research ; Medicine ; Medicine & Public Health ; Methods ; Monoclonal Gammopathy of Undetermined Significance - pathology ; Multiple myeloma ; Oncology ; original-article ; Patients ; Plasma ; Prognosis ; Proteins ; Research centers ; Risk factors</subject><ispartof>Leukemia, 2014-01, Vol.28 (1), p.174-178</ispartof><rights>Macmillan Publishers Limited 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-8bc1c97cee9268c185c9c546aaadf1ff614c9a859eef35926fc79504ceb36f343</citedby><cites>FETCH-LOGICAL-c488t-8bc1c97cee9268c185c9c546aaadf1ff614c9a859eef35926fc79504ceb36f343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/leu.2013.244$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/leu.2013.244$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23958921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hillengass, J</creatorcontrib><creatorcontrib>Weber, M-A</creatorcontrib><creatorcontrib>Kilk, K</creatorcontrib><creatorcontrib>Listl, K</creatorcontrib><creatorcontrib>Wagner-Gund, B</creatorcontrib><creatorcontrib>Hillengass, M</creatorcontrib><creatorcontrib>Hielscher, T</creatorcontrib><creatorcontrib>Farid, A</creatorcontrib><creatorcontrib>Neben, K</creatorcontrib><creatorcontrib>Delorme, S</creatorcontrib><creatorcontrib>Landgren, O</creatorcontrib><creatorcontrib>Goldschmidt, H</creatorcontrib><title>Prognostic significance of whole-body MRI in patients with monoclonal gammopathy of undetermined significance</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>Radiological skeletal survey or computed tomography are currently applied to assess bone diseases in patients with monoclonal plasma cell disorders. Whole-body magnetic resonance imaging (whole-body MRI) allows detecting the infiltration of clonal cells in nearly the whole bone marrow compartment even before bone destruction has occurred. Those MRI results (i.e., patterns of bone marrow infiltration) have been demonstrated to be of prognostic significance in patients with symptomatic as well as asymptomatic multiple myeloma. We have therefore analyzed the findings of whole-body MRI in 137 consecutive individuals with monoclonal gammopathy of undetermined significance (MGUS). A focal infiltration pattern was detected in 23.4% of patients. Presence and number of focal lesions as well as value of M-Protein were of independent prognostic significance for progression into a symptomatic disease requiring systemic treatment (
P
=0.02;
P
<0.0001 and
P
=0.0005, respectively). Lower homogeneous signal intensities in T1-weighted images were related to a physiologically higher bone marrow cellularity in younger individuals (
P
=0.002). We conclude that whole-body MRI identifies patients with focal accumulations of presumably monoclonal cells in bone marrow with prognostic impact concerning the risk of progression into symptomatic disease.</description><subject>692/699/249/1573</subject><subject>692/699/67/1990/804</subject><subject>692/700/1421/1628</subject><subject>692/700/1750</subject><subject>Asymptomatic</subject><subject>Bone marrow</subject><subject>Cancer Research</subject><subject>Critical Care Medicine</subject><subject>Disease</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunologic diseases</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methods</subject><subject>Monoclonal Gammopathy of Undetermined Significance - pathology</subject><subject>Multiple myeloma</subject><subject>Oncology</subject><subject>original-article</subject><subject>Patients</subject><subject>Plasma</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Research centers</subject><subject>Risk factors</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFksFrFDEYxQdR7Fq9eZYBofTgrJNJMkmOpVgtVBTRc8hmvsymZJI1yVD2vzfDVu1KQXII5P2-B-_Lq6rXqF2jFvP3DuZ11yK87gh5Uq0QYX1DKUVPq1XLOWt60ZGT6kVKt227iP3z6qTDgnLRoVU1fY1h9CFlq-tkR2-N1cprqIOp77bBQbMJw77-_O26tr7eqWzB51Tf2bytp-CDdsErV49qmkJRt_tlcPYDZIiT9TAcub6snhnlEry6v0-rH1cfvl9-am6-fLy-vLhpNOE8N3yjkRZMA4iu5xpxqoWmpFdKDQYZ0yOiheJUABhMC2M0E7QlGja4N5jg0-r84LuL4ecMKcvJJg3OKQ9hThLRsiwkCEb_R4loWccZ6wr69h_0NsyxxF8oRlHXE4b_UqNyIK03IUelF1N5gSkTPS_fUKj1I1Q5A0xWBw_GlvejgbMHA1tQLm9TcHO2wadj8N0B1DGkFMHIXbSTinuJWrk0RpbGyKUxsiyh4G_uQ82bCYY_8O-KFKA5AKlIfoT4IPVjhr8Ap2DJmA</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Hillengass, J</creator><creator>Weber, M-A</creator><creator>Kilk, K</creator><creator>Listl, K</creator><creator>Wagner-Gund, B</creator><creator>Hillengass, M</creator><creator>Hielscher, T</creator><creator>Farid, A</creator><creator>Neben, K</creator><creator>Delorme, S</creator><creator>Landgren, O</creator><creator>Goldschmidt, H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Prognostic significance of whole-body MRI in patients with monoclonal gammopathy of undetermined significance</title><author>Hillengass, J ; Weber, M-A ; Kilk, K ; Listl, K ; Wagner-Gund, B ; Hillengass, M ; Hielscher, T ; Farid, A ; Neben, K ; Delorme, S ; Landgren, O ; Goldschmidt, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-8bc1c97cee9268c185c9c546aaadf1ff614c9a859eef35926fc79504ceb36f343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>692/699/249/1573</topic><topic>692/699/67/1990/804</topic><topic>692/700/1421/1628</topic><topic>692/700/1750</topic><topic>Asymptomatic</topic><topic>Bone marrow</topic><topic>Cancer Research</topic><topic>Critical Care Medicine</topic><topic>Disease</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Immunologic diseases</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methods</topic><topic>Monoclonal Gammopathy of Undetermined Significance - pathology</topic><topic>Multiple myeloma</topic><topic>Oncology</topic><topic>original-article</topic><topic>Patients</topic><topic>Plasma</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Research centers</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hillengass, J</creatorcontrib><creatorcontrib>Weber, M-A</creatorcontrib><creatorcontrib>Kilk, K</creatorcontrib><creatorcontrib>Listl, K</creatorcontrib><creatorcontrib>Wagner-Gund, B</creatorcontrib><creatorcontrib>Hillengass, M</creatorcontrib><creatorcontrib>Hielscher, T</creatorcontrib><creatorcontrib>Farid, A</creatorcontrib><creatorcontrib>Neben, K</creatorcontrib><creatorcontrib>Delorme, S</creatorcontrib><creatorcontrib>Landgren, O</creatorcontrib><creatorcontrib>Goldschmidt, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hillengass, J</au><au>Weber, M-A</au><au>Kilk, K</au><au>Listl, K</au><au>Wagner-Gund, B</au><au>Hillengass, M</au><au>Hielscher, T</au><au>Farid, A</au><au>Neben, K</au><au>Delorme, S</au><au>Landgren, O</au><au>Goldschmidt, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of whole-body MRI in patients with monoclonal gammopathy of undetermined significance</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>28</volume><issue>1</issue><spage>174</spage><epage>178</epage><pages>174-178</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><abstract>Radiological skeletal survey or computed tomography are currently applied to assess bone diseases in patients with monoclonal plasma cell disorders. Whole-body magnetic resonance imaging (whole-body MRI) allows detecting the infiltration of clonal cells in nearly the whole bone marrow compartment even before bone destruction has occurred. Those MRI results (i.e., patterns of bone marrow infiltration) have been demonstrated to be of prognostic significance in patients with symptomatic as well as asymptomatic multiple myeloma. We have therefore analyzed the findings of whole-body MRI in 137 consecutive individuals with monoclonal gammopathy of undetermined significance (MGUS). A focal infiltration pattern was detected in 23.4% of patients. Presence and number of focal lesions as well as value of M-Protein were of independent prognostic significance for progression into a symptomatic disease requiring systemic treatment (
P
=0.02;
P
<0.0001 and
P
=0.0005, respectively). Lower homogeneous signal intensities in T1-weighted images were related to a physiologically higher bone marrow cellularity in younger individuals (
P
=0.002). We conclude that whole-body MRI identifies patients with focal accumulations of presumably monoclonal cells in bone marrow with prognostic impact concerning the risk of progression into symptomatic disease.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23958921</pmid><doi>10.1038/leu.2013.244</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals |
| subjects | 692/699/249/1573 692/699/67/1990/804 692/700/1421/1628 692/700/1750 Asymptomatic Bone marrow Cancer Research Critical Care Medicine Disease Hematology Humans Immunoglobulins Immunologic diseases Intensive Internal Medicine Leukemia Magnetic resonance imaging Magnetic Resonance Imaging - methods Medical prognosis Medical research Medicine Medicine & Public Health Methods Monoclonal Gammopathy of Undetermined Significance - pathology Multiple myeloma Oncology original-article Patients Plasma Prognosis Proteins Research centers Risk factors |
| title | Prognostic significance of whole-body MRI in patients with monoclonal gammopathy of undetermined significance |
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