Mapping of amide, amine, and aliphatic peaks in the CEST spectra of murine xenografts at 7 T

Purpose To evaluate the performance of endogenous chemical exchange saturation transfer (CEST) spectra and derived maps in a longitudinal study of tumor xenografts to ascertain the role of CEST parameters in describing tumor progression and in distinguishing between tumor, muscle, and necrosis. Meth...

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Veröffentlicht in:	Magnetic resonance in medicine 2014-05, Vol.71 (5), p.1841-1853
Hauptverfasser:	Desmond, Kimberly L., Moosvi, Firas, Stanisz, Greg J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms aliphatic amide Amides - chemistry amine Amines - chemistry Animals Biomarkers, Tumor - chemistry Cell Line, Tumor CEST chemical exchange saturation transfer Humans Lorentzian Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Mice Mice, SCID Molecular Imaging - methods Neoplasms, Experimental - chemistry Neoplasms, Experimental - pathology Reproducibility of Results Sensitivity and Specificity tumor
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