Biodegradable Hyperbranched Polyglycerol with Ester Linkages for Drug Delivery
Biodegradable hyperbranched polyglycerols (dHPGs) were synthesized through oxyanionic initiating hybrid polymerization of glycerol and glycidyl methacrylate. Due to the introduction of ester linkages into the hyperbranched polyglycerol backbone, dHPGs showed good biodegradability and low cytotoxicit...
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| Veröffentlicht in: | Biomacromolecules 2012-11, Vol.13 (11), p.3552-3561 |
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| container_title | Biomacromolecules |
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| creator | Hu, Mei Chen, Mingsheng Li, Guolin Pang, Yan Wang, Dali Wu, Jieli Qiu, Feng Zhu, Xinyuan Sun, Jian |
| description | Biodegradable hyperbranched polyglycerols (dHPGs) were synthesized through oxyanionic initiating hybrid polymerization of glycerol and glycidyl methacrylate. Due to the introduction of ester linkages into the hyperbranched polyglycerol backbone, dHPGs showed good biodegradability and low cytotoxicity. Benefiting from the existence of terminal hydroxyls and methacryloyl groups, both the anticancer drug methotrexate (MTX) and fluorescent probe Rhodamine-123 could be conjugated onto the surface of dHPGs easily. The resultant MTX-conjugated polymers (dHPG-MTXs) exhibited an amphiphilic character, resulting in the formation of micelles in an aqueous solution. The release of MTX from micelles was significantly faster at mildly acidic pH of 5.0 compared to physiological pH of 7.4. dHPG-MTX micelles could be efficiently internalized by cancer cells. MTT assay against cancer cells showed dHPG-MTXs micelles had high anticancer efficacy. On the basis of their good biodegradability and low cytotoxicity, dHPGs provide an opportunity to design excellent drug delivery systems. |
| doi_str_mv | 10.1021/bm300966d |
| format | Article |
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Due to the introduction of ester linkages into the hyperbranched polyglycerol backbone, dHPGs showed good biodegradability and low cytotoxicity. Benefiting from the existence of terminal hydroxyls and methacryloyl groups, both the anticancer drug methotrexate (MTX) and fluorescent probe Rhodamine-123 could be conjugated onto the surface of dHPGs easily. The resultant MTX-conjugated polymers (dHPG-MTXs) exhibited an amphiphilic character, resulting in the formation of micelles in an aqueous solution. The release of MTX from micelles was significantly faster at mildly acidic pH of 5.0 compared to physiological pH of 7.4. dHPG-MTX micelles could be efficiently internalized by cancer cells. MTT assay against cancer cells showed dHPG-MTXs micelles had high anticancer efficacy. On the basis of their good biodegradability and low cytotoxicity, dHPGs provide an opportunity to design excellent drug delivery systems.</description><identifier>ISSN: 1525-7797</identifier><identifier>EISSN: 1526-4602</identifier><identifier>DOI: 10.1021/bm300966d</identifier><identifier>PMID: 22998016</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>3T3 Cells ; Animals ; Applied sciences ; Biological and medical sciences ; Biological Transport ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Drug Carriers - chemistry ; Exact sciences and technology ; General pharmacology ; Glycerol - chemical synthesis ; Glycerol - chemistry ; Glycerol - metabolism ; HeLa Cells ; Humans ; Medical sciences ; Methotrexate - administration & dosage ; Methotrexate - chemistry ; Methotrexate - pharmacology ; Mice ; Micelles ; Organic polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Polymers - chemical synthesis ; Polymers - chemistry ; Polymers - metabolism ; Polymers with particular properties ; Preparation, kinetics, thermodynamics, mechanism and catalysts ; Rhodamine 123 - administration & dosage ; Rhodamine 123 - chemistry ; Rhodamine 123 - pharmacology</subject><ispartof>Biomacromolecules, 2012-11, Vol.13 (11), p.3552-3561</ispartof><rights>Copyright © 2012 American Chemical Society</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a378t-d116f13f091f11ff17afc40ad92fd1e2f8117f52f0cc858690686823f3c06aae3</citedby><cites>FETCH-LOGICAL-a378t-d116f13f091f11ff17afc40ad92fd1e2f8117f52f0cc858690686823f3c06aae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/bm300966d$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/bm300966d$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26603275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22998016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Mei</creatorcontrib><creatorcontrib>Chen, Mingsheng</creatorcontrib><creatorcontrib>Li, Guolin</creatorcontrib><creatorcontrib>Pang, Yan</creatorcontrib><creatorcontrib>Wang, Dali</creatorcontrib><creatorcontrib>Wu, Jieli</creatorcontrib><creatorcontrib>Qiu, Feng</creatorcontrib><creatorcontrib>Zhu, Xinyuan</creatorcontrib><creatorcontrib>Sun, Jian</creatorcontrib><title>Biodegradable Hyperbranched Polyglycerol with Ester Linkages for Drug Delivery</title><title>Biomacromolecules</title><addtitle>Biomacromolecules</addtitle><description>Biodegradable hyperbranched polyglycerols (dHPGs) were synthesized through oxyanionic initiating hybrid polymerization of glycerol and glycidyl methacrylate. Due to the introduction of ester linkages into the hyperbranched polyglycerol backbone, dHPGs showed good biodegradability and low cytotoxicity. Benefiting from the existence of terminal hydroxyls and methacryloyl groups, both the anticancer drug methotrexate (MTX) and fluorescent probe Rhodamine-123 could be conjugated onto the surface of dHPGs easily. The resultant MTX-conjugated polymers (dHPG-MTXs) exhibited an amphiphilic character, resulting in the formation of micelles in an aqueous solution. The release of MTX from micelles was significantly faster at mildly acidic pH of 5.0 compared to physiological pH of 7.4. dHPG-MTX micelles could be efficiently internalized by cancer cells. MTT assay against cancer cells showed dHPG-MTXs micelles had high anticancer efficacy. On the basis of their good biodegradability and low cytotoxicity, dHPGs provide an opportunity to design excellent drug delivery systems.</description><subject>3T3 Cells</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Biological Transport</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Drug Carriers - chemistry</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Glycerol - chemical synthesis</subject><subject>Glycerol - chemistry</subject><subject>Glycerol - metabolism</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Methotrexate - administration & dosage</subject><subject>Methotrexate - chemistry</subject><subject>Methotrexate - pharmacology</subject><subject>Mice</subject><subject>Micelles</subject><subject>Organic polymers</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Polymers - chemical synthesis</subject><subject>Polymers - chemistry</subject><subject>Polymers - metabolism</subject><subject>Polymers with particular properties</subject><subject>Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><subject>Rhodamine 123 - administration & dosage</subject><subject>Rhodamine 123 - chemistry</subject><subject>Rhodamine 123 - pharmacology</subject><issn>1525-7797</issn><issn>1526-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0LFOwzAQgGELgWgpDLwAyoIEQ8DnJE48QlsoUgUMMEeOc25T3KbYCShvT9oGWJCYfMOnO_kn5BToFVAG19kyoFRwnu-RPkSM-yGnbH87R34ci7hHjpxb0BYFYXRIeowJkVDgffJ4W5Q5zqzMZWbQmzRrtJmVKzXH3HsuTTMzjUJbGu-zqObe2FVovWmxepMzdJ4urTey9cwboSk-0DbH5EBL4_Ckewfk9W78Mpz406f7h-HN1JdBnFR-DsA1BJoK0ABaQyy1CqnMBdM5INMJQKwjpqlSSZRwQXnCExboQFEuJQYDcrHbu7ble42uSpeFU2iMXGFZu7T9eRiCYBH9n0IEMQURRy293FFlS-cs6nRti6W0TQo03ZROf0q39qxbW2dLzH_kd9oWnHdAOiWN3kQt3K_jnAZse7RzUrl0UdZ21Yb74-AXIwCQsA</recordid><startdate>20121112</startdate><enddate>20121112</enddate><creator>Hu, Mei</creator><creator>Chen, Mingsheng</creator><creator>Li, Guolin</creator><creator>Pang, Yan</creator><creator>Wang, Dali</creator><creator>Wu, Jieli</creator><creator>Qiu, Feng</creator><creator>Zhu, Xinyuan</creator><creator>Sun, Jian</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20121112</creationdate><title>Biodegradable Hyperbranched Polyglycerol with Ester Linkages for Drug Delivery</title><author>Hu, Mei ; Chen, Mingsheng ; Li, Guolin ; Pang, Yan ; Wang, Dali ; Wu, Jieli ; Qiu, Feng ; Zhu, Xinyuan ; Sun, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a378t-d116f13f091f11ff17afc40ad92fd1e2f8117f52f0cc858690686823f3c06aae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>3T3 Cells</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Biological Transport</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Drug Carriers - chemistry</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Glycerol - chemical synthesis</topic><topic>Glycerol - chemistry</topic><topic>Glycerol - metabolism</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Methotrexate - administration & dosage</topic><topic>Methotrexate - chemistry</topic><topic>Methotrexate - pharmacology</topic><topic>Mice</topic><topic>Micelles</topic><topic>Organic polymers</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Polymers - chemical synthesis</topic><topic>Polymers - chemistry</topic><topic>Polymers - metabolism</topic><topic>Polymers with particular properties</topic><topic>Preparation, kinetics, thermodynamics, mechanism and catalysts</topic><topic>Rhodamine 123 - administration & dosage</topic><topic>Rhodamine 123 - chemistry</topic><topic>Rhodamine 123 - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Mei</creatorcontrib><creatorcontrib>Chen, Mingsheng</creatorcontrib><creatorcontrib>Li, Guolin</creatorcontrib><creatorcontrib>Pang, Yan</creatorcontrib><creatorcontrib>Wang, Dali</creatorcontrib><creatorcontrib>Wu, Jieli</creatorcontrib><creatorcontrib>Qiu, Feng</creatorcontrib><creatorcontrib>Zhu, Xinyuan</creatorcontrib><creatorcontrib>Sun, Jian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biomacromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Mei</au><au>Chen, Mingsheng</au><au>Li, Guolin</au><au>Pang, Yan</au><au>Wang, Dali</au><au>Wu, Jieli</au><au>Qiu, Feng</au><au>Zhu, Xinyuan</au><au>Sun, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biodegradable Hyperbranched Polyglycerol with Ester Linkages for Drug Delivery</atitle><jtitle>Biomacromolecules</jtitle><addtitle>Biomacromolecules</addtitle><date>2012-11-12</date><risdate>2012</risdate><volume>13</volume><issue>11</issue><spage>3552</spage><epage>3561</epage><pages>3552-3561</pages><issn>1525-7797</issn><eissn>1526-4602</eissn><abstract>Biodegradable hyperbranched polyglycerols (dHPGs) were synthesized through oxyanionic initiating hybrid polymerization of glycerol and glycidyl methacrylate. Due to the introduction of ester linkages into the hyperbranched polyglycerol backbone, dHPGs showed good biodegradability and low cytotoxicity. Benefiting from the existence of terminal hydroxyls and methacryloyl groups, both the anticancer drug methotrexate (MTX) and fluorescent probe Rhodamine-123 could be conjugated onto the surface of dHPGs easily. The resultant MTX-conjugated polymers (dHPG-MTXs) exhibited an amphiphilic character, resulting in the formation of micelles in an aqueous solution. The release of MTX from micelles was significantly faster at mildly acidic pH of 5.0 compared to physiological pH of 7.4. dHPG-MTX micelles could be efficiently internalized by cancer cells. MTT assay against cancer cells showed dHPG-MTXs micelles had high anticancer efficacy. On the basis of their good biodegradability and low cytotoxicity, dHPGs provide an opportunity to design excellent drug delivery systems.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>22998016</pmid><doi>10.1021/bm300966d</doi><tpages>10</tpages></addata></record> |
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| subjects | 3T3 Cells Animals Applied sciences Biological and medical sciences Biological Transport Cell Line, Tumor Cell Proliferation - drug effects Drug Carriers - chemistry Exact sciences and technology General pharmacology Glycerol - chemical synthesis Glycerol - chemistry Glycerol - metabolism HeLa Cells Humans Medical sciences Methotrexate - administration & dosage Methotrexate - chemistry Methotrexate - pharmacology Mice Micelles Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymers - chemical synthesis Polymers - chemistry Polymers - metabolism Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts Rhodamine 123 - administration & dosage Rhodamine 123 - chemistry Rhodamine 123 - pharmacology |
| title | Biodegradable Hyperbranched Polyglycerol with Ester Linkages for Drug Delivery |
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