Reduction-Responsive Disassemblable Core-Cross-Linked Micelles Based on Poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)–Lipoic Acid Conjugates for Triggered Intracellular Anticancer Drug Release

Reduction-sensitive reversibly core-cross-linked micelles were developed based on poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)–lipoic acid (PEG-b-PHPMA-LA) conjugates and investigated for triggered doxorubicin (DOX) release. Water-soluble PEG-b-PHPMA block copolymers were obtained...

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Veröffentlicht in:	Biomacromolecules 2012-08, Vol.13 (8), p.2429-2438
Hauptverfasser:	Wei, Rongran, Cheng, Liang, Zheng, Meng, Cheng, Ru, Meng, Fenghua, Deng, Chao, Zhong, Zhiyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Applied sciences Biological and medical sciences Cell Survival - drug effects Doxorubicin - chemistry Doxorubicin - metabolism Doxorubicin - pharmacology Drug Carriers Exact sciences and technology General pharmacology HeLa Cells Hep G2 Cells Humans Medical sciences Micelles Organic polymers Oxidation-Reduction Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polyethylene Glycols - chemistry Polymerization Polymers with particular properties Polymethacrylic Acids - chemistry Preparation, kinetics, thermodynamics, mechanism and catalysts Thioctic Acid - analogs & derivatives Thioctic Acid - chemical synthesis Thioctic Acid - chemistry
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