Discovery of two GLP-1/Notch target genes that account for the role of GLP-1/Notch signaling in stem cell maintenance

A stem cell's immediate microenvironment creates an essential "niche" to maintain stem cell self-renewal. Many niches and their intercellular signaling pathways are known, but for the most part, the key downstream targets of niche signaling remain elusive. Here, we report the discover...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-03, Vol.111 (10), p.3739-3744
Hauptverfasser:	Kershner, Aaron M., Shin, Heaji, Hansen, Tyler J., Kimble, Judith
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Benzimidazoles Biological Sciences Caenorhabditis elegans Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cellular biology Gene expression regulation Gene Expression Regulation - genetics Gene Expression Regulation - physiology Genes Genetics Germ cells Glucagon-Like Peptide 1 - genetics Glucagon-Like Peptide 1 - metabolism Gonads Immunohistochemistry In Situ Hybridization Larvae Larval development Messenger RNA Nematoda Phenotypes Polysorbates Receptors, Notch - metabolism RNA Interference Signal Transduction - physiology Spermatozoa Stem cells Stem Cells - physiology
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