Association between the P53 codon 72 polymorphism and nasopharyngeal cancer risk
The P53 codon 72 polymorphism has been identified as a critical biomarker in modifying the risk of nasopharyngeal cancer (NPC). Many studies have investigated the association between the polymorphism of P53 codon 72 and NPC risk; however, the findings across the published studies are inconsistent an...
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| Veröffentlicht in: | Tumor biology 2014-03, Vol.35 (3), p.1891-1897 |
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| creator | Cai, Kemin Wang, Yu Zhao, Xiaojun Bao, Xueli |
| description | The P53 codon 72 polymorphism has been identified as a critical biomarker in modifying the risk of nasopharyngeal cancer (NPC). Many studies have investigated the association between the polymorphism of P53 codon 72 and NPC risk; however, the findings across the published studies are inconsistent and inconclusive. To acquire a more precise assessment for this association, we conducted an updated meta-analysis. The PubMed, Embase, Web of Science, and Wanfang databases were searched for relevant case–control studies. Totally, seven independent publications with 1,133 cases and 1,678 controls were retrieved. The pooled odds ratio (OR) with corresponding 95 % confidence interval (95 % CI) was calculated. Increased risk of NPC was observed among individuals carrying the variant allele and genotypes of P53 codon 72 (OR
Pro vs. Arg
= 1.32, 95 % CI 1.18–1.47,
P
OR
|
| doi_str_mv | 10.1007/s13277-013-1254-5 |
| format | Article |
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Pro vs. Arg
= 1.32, 95 % CI 1.18–1.47,
P
OR
< 0.001; OR
ProPro vs. ArgArg
= 1.90, 95 % CI 1.51–2.39,
P
OR
< 0.001; OR
ProArg + ProPro vs. ArgArg
= 1.33, 95 % CI 1.13–1.57,
P
OR
= 0.001; OR
ProPro vs. ArgArg + ProArg
= 1.65, 95 % CI 1.35–2.01,
P
OR
< 0.001). Stratified analyses by ethnicity and source of controls also identified this significant relationship in Asians, Caucasians, and hospital-based case–control studies. There was no publication bias risk in our study. The updated meta-analysis supports the evidence that the polymorphism of P53 codon 72 is a risk factor for the development of NPC among the populations of both Asian and Caucasian.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-013-1254-5</identifier><identifier>PMID: 24114013</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Asian Continental Ancestry Group - genetics ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Case-Control Studies ; Codon ; European Continental Ancestry Group - genetics ; Genes ; Genetic Predisposition to Disease - genetics ; Humans ; Meta-analysis ; Nasopharyngeal Neoplasms - genetics ; Odds Ratio ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Research Article ; Risk Factors ; Throat cancer ; Tumor Suppressor Protein p53 - genetics</subject><ispartof>Tumor biology, 2014-03, Vol.35 (3), p.1891-1897</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2013</rights><rights>International Society of Oncology and BioMarkers (ISOBM) 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-1e840e9534d60a4cf809cf4803a0798fc8e487dbf46fccf35885eed23fa15f5f3</citedby><cites>FETCH-LOGICAL-c405t-1e840e9534d60a4cf809cf4803a0798fc8e487dbf46fccf35885eed23fa15f5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-013-1254-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-013-1254-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24114013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Kemin</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Zhao, Xiaojun</creatorcontrib><creatorcontrib>Bao, Xueli</creatorcontrib><title>Association between the P53 codon 72 polymorphism and nasopharyngeal cancer risk</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>The P53 codon 72 polymorphism has been identified as a critical biomarker in modifying the risk of nasopharyngeal cancer (NPC). Many studies have investigated the association between the polymorphism of P53 codon 72 and NPC risk; however, the findings across the published studies are inconsistent and inconclusive. To acquire a more precise assessment for this association, we conducted an updated meta-analysis. The PubMed, Embase, Web of Science, and Wanfang databases were searched for relevant case–control studies. Totally, seven independent publications with 1,133 cases and 1,678 controls were retrieved. The pooled odds ratio (OR) with corresponding 95 % confidence interval (95 % CI) was calculated. Increased risk of NPC was observed among individuals carrying the variant allele and genotypes of P53 codon 72 (OR
Pro vs. Arg
= 1.32, 95 % CI 1.18–1.47,
P
OR
< 0.001; OR
ProPro vs. ArgArg
= 1.90, 95 % CI 1.51–2.39,
P
OR
< 0.001; OR
ProArg + ProPro vs. ArgArg
= 1.33, 95 % CI 1.13–1.57,
P
OR
= 0.001; OR
ProPro vs. ArgArg + ProArg
= 1.65, 95 % CI 1.35–2.01,
P
OR
< 0.001). Stratified analyses by ethnicity and source of controls also identified this significant relationship in Asians, Caucasians, and hospital-based case–control studies. There was no publication bias risk in our study. The updated meta-analysis supports the evidence that the polymorphism of P53 codon 72 is a risk factor for the development of NPC among the populations of both Asian and Caucasian.</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Codon</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Humans</subject><subject>Meta-analysis</subject><subject>Nasopharyngeal Neoplasms - genetics</subject><subject>Odds Ratio</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Research Article</subject><subject>Risk Factors</subject><subject>Throat cancer</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc1LHTEUxUNR6kf7B3RTAm7cTL03HzOZpUirBUEXug55mZu-0ZnJNJmH-N83j6elCAVXueT-zgk5h7EvCN8QoDnLKEXTVICyQqFVpT-wQ1RCViAN7JUZEColjDxgRzk_AKBu2_ojOxAKURXZIbs9zzn63i19nPiKlieiiS9r4rdach-7ctsIPsfheYxpXvd55G7q-ORynNcuPU-_yA3cu8lT4qnPj5_YfnBDps8v5zG7__H97uKqur65_Hlxfl15BXqpkIwCarVUXQ1O-WCg9UEZkA6a1gRvSJmmWwVVB--D1MZook7I4FAHHeQxO935zin-3lBe7NhnT8PgJoqbbFELpbC4tu9AEWVb63qLnrxBH-ImTeUjWwpkI1tUhcId5VPMOVGwc-rHkoZFsNtm7K4ZWyK222asLpqvL86b1UjdX8VrFQUQOyCXVYk1_fP0f13_APXblxk</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Cai, Kemin</creator><creator>Wang, Yu</creator><creator>Zhao, Xiaojun</creator><creator>Bao, Xueli</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Association between the P53 codon 72 polymorphism and nasopharyngeal cancer risk</title><author>Cai, Kemin ; Wang, Yu ; Zhao, Xiaojun ; Bao, Xueli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-1e840e9534d60a4cf809cf4803a0798fc8e487dbf46fccf35885eed23fa15f5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Codon</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Humans</topic><topic>Meta-analysis</topic><topic>Nasopharyngeal Neoplasms - genetics</topic><topic>Odds Ratio</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Research Article</topic><topic>Risk Factors</topic><topic>Throat cancer</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Kemin</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Zhao, Xiaojun</creatorcontrib><creatorcontrib>Bao, Xueli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Kemin</au><au>Wang, Yu</au><au>Zhao, Xiaojun</au><au>Bao, Xueli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between the P53 codon 72 polymorphism and nasopharyngeal cancer risk</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>35</volume><issue>3</issue><spage>1891</spage><epage>1897</epage><pages>1891-1897</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>The P53 codon 72 polymorphism has been identified as a critical biomarker in modifying the risk of nasopharyngeal cancer (NPC). Many studies have investigated the association between the polymorphism of P53 codon 72 and NPC risk; however, the findings across the published studies are inconsistent and inconclusive. To acquire a more precise assessment for this association, we conducted an updated meta-analysis. The PubMed, Embase, Web of Science, and Wanfang databases were searched for relevant case–control studies. Totally, seven independent publications with 1,133 cases and 1,678 controls were retrieved. The pooled odds ratio (OR) with corresponding 95 % confidence interval (95 % CI) was calculated. Increased risk of NPC was observed among individuals carrying the variant allele and genotypes of P53 codon 72 (OR
Pro vs. Arg
= 1.32, 95 % CI 1.18–1.47,
P
OR
< 0.001; OR
ProPro vs. ArgArg
= 1.90, 95 % CI 1.51–2.39,
P
OR
< 0.001; OR
ProArg + ProPro vs. ArgArg
= 1.33, 95 % CI 1.13–1.57,
P
OR
= 0.001; OR
ProPro vs. ArgArg + ProArg
= 1.65, 95 % CI 1.35–2.01,
P
OR
< 0.001). Stratified analyses by ethnicity and source of controls also identified this significant relationship in Asians, Caucasians, and hospital-based case–control studies. There was no publication bias risk in our study. The updated meta-analysis supports the evidence that the polymorphism of P53 codon 72 is a risk factor for the development of NPC among the populations of both Asian and Caucasian.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24114013</pmid><doi>10.1007/s13277-013-1254-5</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Tumor biology, 2014-03, Vol.35 (3), p.1891-1897 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Asian Continental Ancestry Group - genetics Biomarkers Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Codon European Continental Ancestry Group - genetics Genes Genetic Predisposition to Disease - genetics Humans Meta-analysis Nasopharyngeal Neoplasms - genetics Odds Ratio Polymorphism Polymorphism, Single Nucleotide - genetics Research Article Risk Factors Throat cancer Tumor Suppressor Protein p53 - genetics |
| title | Association between the P53 codon 72 polymorphism and nasopharyngeal cancer risk |
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