Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A

Abstract Chemoresistance is a major obstacle to effective therapy against colorectal cancer (CRC) and may lead to deadly consequences. The metabolism of CRC cells depends highly on the p38 MAPK pathway, whose involvement in maintaining a chemoresistant behavior is currently being investigated. Our p...

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Veröffentlicht in:	Cancer letters 2014-03, Vol.344 (1), p.110-118
Hauptverfasser:	Germani, Aldo, Matrone, Antonio, Grossi, Valentina, Peserico, Alessia, Sanese, Paola, Liuzzi, Micaela, Palermo, Rocco, Murzilli, Stefania, Campese, Antonio Francesco, Ingravallo, Giuseppe, Canettieri, Gianluca, Tezil, Tugsan, Simone, Cristiano
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Survival Cisplatin - pharmacology Colorectal Neoplasms - metabolism Drug Resistance, Neoplasm - physiology Female Flow Cytometry Fluorescent Antibody Technique Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism Hematology, Oncology and Palliative Medicine HT29 Cells Humans Immunoblotting Mice Mice, Nude Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors Molecular Targeted Therapy - methods Real-Time Polymerase Chain Reaction Xenograft Model Antitumor Assays
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