Effects of combined therapy of alendronate and low-intensity pulsed ultrasound on metaphyseal bone repair after osteotomy in the proximal tibia of aged rats
Bisphosphonates and low-intensity pulsed ultrasound (LIPUS) are both known to maintain or promote callus formation during diaphyseal fracture healing. However, the effect of these treatments on the repair of metaphyseal fractures has not been elucidated. To evaluate the effects of bisphosphonates an...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2014-05, Vol.32 (3), p.232-239 |
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| creator | Aonuma, Hiroshi Miyakoshi, Naohisa Kasukawa, Yuji Kamo, Keiji Sasaki, Hiroshi Tsuchie, Hiroyuki Segawa, Toyohito Shimada, Yoichi |
| description | Bisphosphonates and low-intensity pulsed ultrasound (LIPUS) are both known to maintain or promote callus formation during diaphyseal fracture healing. However, the effect of these treatments on the repair of metaphyseal fractures has not been elucidated. To evaluate the effects of bisphosphonates and/or LIPUS on cancellous bone healing, an osteotomy was performed on the proximal tibial metaphysis of 9-month-old Sprague–Dawley rats (
n
= 64). Treatment with alendronate (1 μg/kg/day), LIPUS (20 min/day), or a combination of both was administered for 2 or 4 weeks, after which changes in bone mineral density (BMD), bone histomorphometric parameters, and the rate of cancellous bony bonding were measured. Alendronate suppressed bone resorption parameters at 2 weeks (
p
= 0.019) and increased bone volume and BMD at 4 weeks (
p
= 0.034 and
p
= 0.008, respectively), without affecting bony bonding. LIPUS had no significant effect on any of the histomorphometric parameters at 2 or 4 weeks, but significantly increased in BMD at 4 weeks (
p
= 0.026) as well as the percentage of bony bonding at both 2 and 4 weeks (
p
|
| doi_str_mv | 10.1007/s00774-013-0492-3 |
| format | Article |
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n
= 64). Treatment with alendronate (1 μg/kg/day), LIPUS (20 min/day), or a combination of both was administered for 2 or 4 weeks, after which changes in bone mineral density (BMD), bone histomorphometric parameters, and the rate of cancellous bony bonding were measured. Alendronate suppressed bone resorption parameters at 2 weeks (
p
= 0.019) and increased bone volume and BMD at 4 weeks (
p
= 0.034 and
p
= 0.008, respectively), without affecting bony bonding. LIPUS had no significant effect on any of the histomorphometric parameters at 2 or 4 weeks, but significantly increased in BMD at 4 weeks (
p
= 0.026) as well as the percentage of bony bonding at both 2 and 4 weeks (
p
< 0.01). The combined therapy also showed significantly increased BMD compared with the control group at 4 weeks (
p
= 0.010) and showed a trend toward increased bony bonding. In conclusion, alendronate and LIPUS cause an additive increase in BMD at the affected metaphysis: alendronate increases the bone volume at the osteotomy site without interrupting metaphyseal repair, whereas LIPUS promotes metaphyseal bone repair, without affecting bone histomorphometric parameters.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-013-0492-3</identifier><identifier>PMID: 23921832</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Alendronate - pharmacology ; Animals ; Bone Density - drug effects ; Bone Density - physiology ; Diphosphonates - pharmacology ; Female ; Fracture Healing - drug effects ; Fractures, Bone - drug therapy ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original Article ; Orthopedics ; Osteotomy - methods ; Rats ; Rats, Sprague-Dawley ; Tibia - drug effects ; Tibia - surgery ; Ultrasonics - methods</subject><ispartof>Journal of bone and mineral metabolism, 2014-05, Vol.32 (3), p.232-239</ispartof><rights>The Japanese Society for Bone and Mineral Research and Springer Japan 2013</rights><rights>The Japanese Society for Bone and Mineral Research and Springer Japan 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-71afe062e8ac8ef11d8a9b56aa3419de31acaabb662e1f6579d707546fa39d153</citedby><cites>FETCH-LOGICAL-c462t-71afe062e8ac8ef11d8a9b56aa3419de31acaabb662e1f6579d707546fa39d153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00774-013-0492-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00774-013-0492-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23921832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aonuma, Hiroshi</creatorcontrib><creatorcontrib>Miyakoshi, Naohisa</creatorcontrib><creatorcontrib>Kasukawa, Yuji</creatorcontrib><creatorcontrib>Kamo, Keiji</creatorcontrib><creatorcontrib>Sasaki, Hiroshi</creatorcontrib><creatorcontrib>Tsuchie, Hiroyuki</creatorcontrib><creatorcontrib>Segawa, Toyohito</creatorcontrib><creatorcontrib>Shimada, Yoichi</creatorcontrib><title>Effects of combined therapy of alendronate and low-intensity pulsed ultrasound on metaphyseal bone repair after osteotomy in the proximal tibia of aged rats</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><addtitle>J Bone Miner Metab</addtitle><description>Bisphosphonates and low-intensity pulsed ultrasound (LIPUS) are both known to maintain or promote callus formation during diaphyseal fracture healing. However, the effect of these treatments on the repair of metaphyseal fractures has not been elucidated. To evaluate the effects of bisphosphonates and/or LIPUS on cancellous bone healing, an osteotomy was performed on the proximal tibial metaphysis of 9-month-old Sprague–Dawley rats (
n
= 64). Treatment with alendronate (1 μg/kg/day), LIPUS (20 min/day), or a combination of both was administered for 2 or 4 weeks, after which changes in bone mineral density (BMD), bone histomorphometric parameters, and the rate of cancellous bony bonding were measured. Alendronate suppressed bone resorption parameters at 2 weeks (
p
= 0.019) and increased bone volume and BMD at 4 weeks (
p
= 0.034 and
p
= 0.008, respectively), without affecting bony bonding. LIPUS had no significant effect on any of the histomorphometric parameters at 2 or 4 weeks, but significantly increased in BMD at 4 weeks (
p
= 0.026) as well as the percentage of bony bonding at both 2 and 4 weeks (
p
< 0.01). The combined therapy also showed significantly increased BMD compared with the control group at 4 weeks (
p
= 0.010) and showed a trend toward increased bony bonding. In conclusion, alendronate and LIPUS cause an additive increase in BMD at the affected metaphysis: alendronate increases the bone volume at the osteotomy site without interrupting metaphyseal repair, whereas LIPUS promotes metaphyseal bone repair, without affecting bone histomorphometric parameters.</description><subject>Alendronate - pharmacology</subject><subject>Animals</subject><subject>Bone Density - drug effects</subject><subject>Bone Density - physiology</subject><subject>Diphosphonates - pharmacology</subject><subject>Female</subject><subject>Fracture Healing - drug effects</subject><subject>Fractures, Bone - drug therapy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteotomy - methods</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tibia - drug effects</subject><subject>Tibia - surgery</subject><subject>Ultrasonics - methods</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU-L1jAQxoMo7uvqB_AiAS9eqpn8adqjLOsfWPCi5zJtJ7td2qQmKfp-l_2wpr6riCB4SSDzm-eZycPYcxCvQQj7JpXD6kqAqoRuZaUesANoZSpTC_2QHUQLumqsbc_Yk5RuhQBrLDxmZ1K1EholD-zu0jkacuLB8SEs_eRp5PmGIq7H_Q1n8mMMHjNx9COfw7dq8pl8mvKRr9ucCr_NOWIKW6kHzxfKuN4cE-HM--CJR1pxihxdpshDyhRyWI588rsRX2P4Pi2FzVM_4U_P66IZMaen7JHD4vDs_j5nX95dfr74UF19ev_x4u1VNeha5soCOhK1pAaHhhzA2GDbmxpRaWhHUoADYt_XBQFXG9uOVlija4eqHcGoc_bqpFtm-bpRyt0ypYHmGT2FLXVgpNagdWP_BwUlm6aWBX35F3obtujLIjsljCkT7N5wooYYUorkujWW74jHDkS3p9ydUu5Kyt2ecqdKz4t75a1faPzd8SvWAsgTkErJX1P8w_qfqj8AWxm02w</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Aonuma, Hiroshi</creator><creator>Miyakoshi, Naohisa</creator><creator>Kasukawa, Yuji</creator><creator>Kamo, Keiji</creator><creator>Sasaki, Hiroshi</creator><creator>Tsuchie, Hiroyuki</creator><creator>Segawa, Toyohito</creator><creator>Shimada, Yoichi</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Effects of combined therapy of alendronate and low-intensity pulsed ultrasound on metaphyseal bone repair after osteotomy in the proximal tibia of aged rats</title><author>Aonuma, Hiroshi ; Miyakoshi, Naohisa ; Kasukawa, Yuji ; Kamo, Keiji ; Sasaki, Hiroshi ; Tsuchie, Hiroyuki ; Segawa, Toyohito ; Shimada, Yoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-71afe062e8ac8ef11d8a9b56aa3419de31acaabb662e1f6579d707546fa39d153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alendronate - pharmacology</topic><topic>Animals</topic><topic>Bone Density - drug effects</topic><topic>Bone Density - physiology</topic><topic>Diphosphonates - pharmacology</topic><topic>Female</topic><topic>Fracture Healing - drug effects</topic><topic>Fractures, Bone - drug therapy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteotomy - methods</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tibia - drug effects</topic><topic>Tibia - surgery</topic><topic>Ultrasonics - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aonuma, Hiroshi</creatorcontrib><creatorcontrib>Miyakoshi, Naohisa</creatorcontrib><creatorcontrib>Kasukawa, Yuji</creatorcontrib><creatorcontrib>Kamo, Keiji</creatorcontrib><creatorcontrib>Sasaki, Hiroshi</creatorcontrib><creatorcontrib>Tsuchie, Hiroyuki</creatorcontrib><creatorcontrib>Segawa, Toyohito</creatorcontrib><creatorcontrib>Shimada, Yoichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aonuma, Hiroshi</au><au>Miyakoshi, Naohisa</au><au>Kasukawa, Yuji</au><au>Kamo, Keiji</au><au>Sasaki, Hiroshi</au><au>Tsuchie, Hiroyuki</au><au>Segawa, Toyohito</au><au>Shimada, Yoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of combined therapy of alendronate and low-intensity pulsed ultrasound on metaphyseal bone repair after osteotomy in the proximal tibia of aged rats</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><stitle>J Bone Miner Metab</stitle><addtitle>J Bone Miner Metab</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>32</volume><issue>3</issue><spage>232</spage><epage>239</epage><pages>232-239</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>Bisphosphonates and low-intensity pulsed ultrasound (LIPUS) are both known to maintain or promote callus formation during diaphyseal fracture healing. However, the effect of these treatments on the repair of metaphyseal fractures has not been elucidated. To evaluate the effects of bisphosphonates and/or LIPUS on cancellous bone healing, an osteotomy was performed on the proximal tibial metaphysis of 9-month-old Sprague–Dawley rats (
n
= 64). Treatment with alendronate (1 μg/kg/day), LIPUS (20 min/day), or a combination of both was administered for 2 or 4 weeks, after which changes in bone mineral density (BMD), bone histomorphometric parameters, and the rate of cancellous bony bonding were measured. Alendronate suppressed bone resorption parameters at 2 weeks (
p
= 0.019) and increased bone volume and BMD at 4 weeks (
p
= 0.034 and
p
= 0.008, respectively), without affecting bony bonding. LIPUS had no significant effect on any of the histomorphometric parameters at 2 or 4 weeks, but significantly increased in BMD at 4 weeks (
p
= 0.026) as well as the percentage of bony bonding at both 2 and 4 weeks (
p
< 0.01). The combined therapy also showed significantly increased BMD compared with the control group at 4 weeks (
p
= 0.010) and showed a trend toward increased bony bonding. In conclusion, alendronate and LIPUS cause an additive increase in BMD at the affected metaphysis: alendronate increases the bone volume at the osteotomy site without interrupting metaphyseal repair, whereas LIPUS promotes metaphyseal bone repair, without affecting bone histomorphometric parameters.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>23921832</pmid><doi>10.1007/s00774-013-0492-3</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of bone and mineral metabolism, 2014-05, Vol.32 (3), p.232-239 |
| issn | 0914-8779 1435-5604 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Alendronate - pharmacology Animals Bone Density - drug effects Bone Density - physiology Diphosphonates - pharmacology Female Fracture Healing - drug effects Fractures, Bone - drug therapy Medicine Medicine & Public Health Metabolic Diseases Original Article Orthopedics Osteotomy - methods Rats Rats, Sprague-Dawley Tibia - drug effects Tibia - surgery Ultrasonics - methods |
| title | Effects of combined therapy of alendronate and low-intensity pulsed ultrasound on metaphyseal bone repair after osteotomy in the proximal tibia of aged rats |
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