Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients
The purpose of this study was to investigate the relationship between head and neck cancer (HNC) and environmental agents and polymorphisms in CYP1A1 , CYP2D6 , NAT1 and NAT2 metabolic enzymes genes. To the best of our knowledge, this is the first report on polymorphisms in CYP1A1 6310C>T, CYP2D6...
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| Veröffentlicht in: | Molecular biology reports 2014-04, Vol.41 (4), p.2591-2600 |
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| creator | Khlifi, Rim Chakroun, Amine Hamza-Chaffai, Amel Rebai, Ahmed |
| description | The purpose of this study was to investigate the relationship between head and neck cancer (HNC) and environmental agents and polymorphisms in
CYP1A1
,
CYP2D6
,
NAT1
and
NAT2
metabolic enzymes genes. To the best of our knowledge, this is the first report on polymorphisms in
CYP1A1
6310C>T,
CYP2D6
Arg365His,
NAT1
52936A>T and
NAT2
Arg268Lys (
NAT2*12A
) genes and susceptibility to HNC in Tunisian population. We study the prevalence of these polymorphisms in 169 patients with HNC and 261 control subjects using polymerase chain reaction based methods in a Tunisian population. We detected an association between HNC and
CYP1A1
6310C>T (TT) and
CYP2D6
Arg365His (His/His) variant carriers (OR 1.75,
P
= 0.008 and OR 1.66,
P
= 0.016, respectively). No association was found between the polymorphisms genotypes of
NAT1
52936T>A and
NAT2
Arg268Lys and risk of HNC. An association between HNC and
CYP1A1
(TT) genotype was found among patients with smoking (
P
= 0.011) and drinking habit (
P
= 0.009). The combinations of
NAT1
(AT or AA) and
NAT2
(AA) at-risk genotypes increased HNC risk (OR 4.23,
P
= 0.005 and OR 3.60,
P
= 0.048, respectively). However, the combinations of
CYP1A1
(AA) and
CYP2D6
(CC) genotypes decreased risk of HNC (OR 0.20;
P
= 0.006). Genetic polymorphisms in
CYP1A1
and
CYP2D6
may significantly associate with HNC in the Tunisian population. The results of this study suggest a possible gene–environment interaction for certain carcinogen metabolizing enzymes, but larger studies that fully evaluate the interaction are needed. |
| doi_str_mv | 10.1007/s11033-014-3117-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1524413092</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1524413092</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-b8c0be38cf0f8118d189883b5e2a010f65ef303c9e8102dbd223c888df7ecac23</originalsourceid><addsrcrecordid>eNp1kU1P3DAQhq2KChbKD-gFWeLSS9qZ2Emc42ppaSUkOMChJ8txJqzpxg52oop_T9KlVYXEaUaaZ975eBn7iPAZAaovCRGEyABlJhCrrHzHVlhUIpN1pQ7YCgRgJlWBR-w4pQcAkFgVh-wol1LWohQr1qxTCtaZ0QXPQ8c3P29wjdz4dknzi5Lfkyc-hN1TH-KwdalP_Lcbt3xLpv3DebK_uDXeUuTO89vJu-SM58MsSn5MH9j7zuwSnb7EE3b37evt5nt2dX35Y7O-yqyEYswaZaEhoWwHnUJULapaKdEUlBtA6MqCOgHC1qQQ8rZp81xYpVTbVWSNzcUJ-7TXHWJ4nCiNunfJ0m5nPIUpaSzms1FAvaDnr9CHMEU_bzdTCJWUhVwo3FM2hpQidXqIrjfxSSPoxQC9N0DPBujFAF3OPWcvylPTU_uv4-_HZyDfA2ku-XuK_41-U_UZs9qOlg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1510744542</pqid></control><display><type>article</type><title>Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Khlifi, Rim ; Chakroun, Amine ; Hamza-Chaffai, Amel ; Rebai, Ahmed</creator><creatorcontrib>Khlifi, Rim ; Chakroun, Amine ; Hamza-Chaffai, Amel ; Rebai, Ahmed</creatorcontrib><description>The purpose of this study was to investigate the relationship between head and neck cancer (HNC) and environmental agents and polymorphisms in
CYP1A1
,
CYP2D6
,
NAT1
and
NAT2
metabolic enzymes genes. To the best of our knowledge, this is the first report on polymorphisms in
CYP1A1
6310C>T,
CYP2D6
Arg365His,
NAT1
52936A>T and
NAT2
Arg268Lys (
NAT2*12A
) genes and susceptibility to HNC in Tunisian population. We study the prevalence of these polymorphisms in 169 patients with HNC and 261 control subjects using polymerase chain reaction based methods in a Tunisian population. We detected an association between HNC and
CYP1A1
6310C>T (TT) and
CYP2D6
Arg365His (His/His) variant carriers (OR 1.75,
P
= 0.008 and OR 1.66,
P
= 0.016, respectively). No association was found between the polymorphisms genotypes of
NAT1
52936T>A and
NAT2
Arg268Lys and risk of HNC. An association between HNC and
CYP1A1
(TT) genotype was found among patients with smoking (
P
= 0.011) and drinking habit (
P
= 0.009). The combinations of
NAT1
(AT or AA) and
NAT2
(AA) at-risk genotypes increased HNC risk (OR 4.23,
P
= 0.005 and OR 3.60,
P
= 0.048, respectively). However, the combinations of
CYP1A1
(AA) and
CYP2D6
(CC) genotypes decreased risk of HNC (OR 0.20;
P
= 0.006). Genetic polymorphisms in
CYP1A1
and
CYP2D6
may significantly associate with HNC in the Tunisian population. The results of this study suggest a possible gene–environment interaction for certain carcinogen metabolizing enzymes, but larger studies that fully evaluate the interaction are needed.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-014-3117-6</identifier><identifier>PMID: 24449363</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alleles ; Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Case-Control Studies ; Cytochrome P-450 CYP1A1 - genetics ; Cytochrome P-450 CYP2D6 - genetics ; Epistasis, Genetic ; Female ; Gene-Environment Interaction ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Head & neck cancer ; Head and Neck Neoplasms - epidemiology ; Head and Neck Neoplasms - genetics ; Head and Neck Neoplasms - pathology ; Histology ; Humans ; Life Sciences ; Male ; Middle Aged ; Molecular biology ; Morphology ; Odds Ratio ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Population genetics ; Risk Factors ; Tunisia ; Young Adult</subject><ispartof>Molecular biology reports, 2014-04, Vol.41 (4), p.2591-2600</ispartof><rights>Springer Science+Business Media Dordrecht 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-b8c0be38cf0f8118d189883b5e2a010f65ef303c9e8102dbd223c888df7ecac23</citedby><cites>FETCH-LOGICAL-c405t-b8c0be38cf0f8118d189883b5e2a010f65ef303c9e8102dbd223c888df7ecac23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-014-3117-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-014-3117-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24449363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khlifi, Rim</creatorcontrib><creatorcontrib>Chakroun, Amine</creatorcontrib><creatorcontrib>Hamza-Chaffai, Amel</creatorcontrib><creatorcontrib>Rebai, Ahmed</creatorcontrib><title>Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>The purpose of this study was to investigate the relationship between head and neck cancer (HNC) and environmental agents and polymorphisms in
CYP1A1
,
CYP2D6
,
NAT1
and
NAT2
metabolic enzymes genes. To the best of our knowledge, this is the first report on polymorphisms in
CYP1A1
6310C>T,
CYP2D6
Arg365His,
NAT1
52936A>T and
NAT2
Arg268Lys (
NAT2*12A
) genes and susceptibility to HNC in Tunisian population. We study the prevalence of these polymorphisms in 169 patients with HNC and 261 control subjects using polymerase chain reaction based methods in a Tunisian population. We detected an association between HNC and
CYP1A1
6310C>T (TT) and
CYP2D6
Arg365His (His/His) variant carriers (OR 1.75,
P
= 0.008 and OR 1.66,
P
= 0.016, respectively). No association was found between the polymorphisms genotypes of
NAT1
52936T>A and
NAT2
Arg268Lys and risk of HNC. An association between HNC and
CYP1A1
(TT) genotype was found among patients with smoking (
P
= 0.011) and drinking habit (
P
= 0.009). The combinations of
NAT1
(AT or AA) and
NAT2
(AA) at-risk genotypes increased HNC risk (OR 4.23,
P
= 0.005 and OR 3.60,
P
= 0.048, respectively). However, the combinations of
CYP1A1
(AA) and
CYP2D6
(CC) genotypes decreased risk of HNC (OR 0.20;
P
= 0.006). Genetic polymorphisms in
CYP1A1
and
CYP2D6
may significantly associate with HNC in the Tunisian population. The results of this study suggest a possible gene–environment interaction for certain carcinogen metabolizing enzymes, but larger studies that fully evaluate the interaction are needed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Case-Control Studies</subject><subject>Cytochrome P-450 CYP1A1 - genetics</subject><subject>Cytochrome P-450 CYP2D6 - genetics</subject><subject>Epistasis, Genetic</subject><subject>Female</subject><subject>Gene-Environment Interaction</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Head & neck cancer</subject><subject>Head and Neck Neoplasms - epidemiology</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Histology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular biology</subject><subject>Morphology</subject><subject>Odds Ratio</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population genetics</subject><subject>Risk Factors</subject><subject>Tunisia</subject><subject>Young Adult</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1P3DAQhq2KChbKD-gFWeLSS9qZ2Emc42ppaSUkOMChJ8txJqzpxg52oop_T9KlVYXEaUaaZ975eBn7iPAZAaovCRGEyABlJhCrrHzHVlhUIpN1pQ7YCgRgJlWBR-w4pQcAkFgVh-wol1LWohQr1qxTCtaZ0QXPQ8c3P29wjdz4dknzi5Lfkyc-hN1TH-KwdalP_Lcbt3xLpv3DebK_uDXeUuTO89vJu-SM58MsSn5MH9j7zuwSnb7EE3b37evt5nt2dX35Y7O-yqyEYswaZaEhoWwHnUJULapaKdEUlBtA6MqCOgHC1qQQ8rZp81xYpVTbVWSNzcUJ-7TXHWJ4nCiNunfJ0m5nPIUpaSzms1FAvaDnr9CHMEU_bzdTCJWUhVwo3FM2hpQidXqIrjfxSSPoxQC9N0DPBujFAF3OPWcvylPTU_uv4-_HZyDfA2ku-XuK_41-U_UZs9qOlg</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Khlifi, Rim</creator><creator>Chakroun, Amine</creator><creator>Hamza-Chaffai, Amel</creator><creator>Rebai, Ahmed</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20140401</creationdate><title>Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients</title><author>Khlifi, Rim ; Chakroun, Amine ; Hamza-Chaffai, Amel ; Rebai, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-b8c0be38cf0f8118d189883b5e2a010f65ef303c9e8102dbd223c888df7ecac23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Case-Control Studies</topic><topic>Cytochrome P-450 CYP1A1 - genetics</topic><topic>Cytochrome P-450 CYP2D6 - genetics</topic><topic>Epistasis, Genetic</topic><topic>Female</topic><topic>Gene-Environment Interaction</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Head & neck cancer</topic><topic>Head and Neck Neoplasms - epidemiology</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Histology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular biology</topic><topic>Morphology</topic><topic>Odds Ratio</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population genetics</topic><topic>Risk Factors</topic><topic>Tunisia</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khlifi, Rim</creatorcontrib><creatorcontrib>Chakroun, Amine</creatorcontrib><creatorcontrib>Hamza-Chaffai, Amel</creatorcontrib><creatorcontrib>Rebai, Ahmed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khlifi, Rim</au><au>Chakroun, Amine</au><au>Hamza-Chaffai, Amel</au><au>Rebai, Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>41</volume><issue>4</issue><spage>2591</spage><epage>2600</epage><pages>2591-2600</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>The purpose of this study was to investigate the relationship between head and neck cancer (HNC) and environmental agents and polymorphisms in
CYP1A1
,
CYP2D6
,
NAT1
and
NAT2
metabolic enzymes genes. To the best of our knowledge, this is the first report on polymorphisms in
CYP1A1
6310C>T,
CYP2D6
Arg365His,
NAT1
52936A>T and
NAT2
Arg268Lys (
NAT2*12A
) genes and susceptibility to HNC in Tunisian population. We study the prevalence of these polymorphisms in 169 patients with HNC and 261 control subjects using polymerase chain reaction based methods in a Tunisian population. We detected an association between HNC and
CYP1A1
6310C>T (TT) and
CYP2D6
Arg365His (His/His) variant carriers (OR 1.75,
P
= 0.008 and OR 1.66,
P
= 0.016, respectively). No association was found between the polymorphisms genotypes of
NAT1
52936T>A and
NAT2
Arg268Lys and risk of HNC. An association between HNC and
CYP1A1
(TT) genotype was found among patients with smoking (
P
= 0.011) and drinking habit (
P
= 0.009). The combinations of
NAT1
(AT or AA) and
NAT2
(AA) at-risk genotypes increased HNC risk (OR 4.23,
P
= 0.005 and OR 3.60,
P
= 0.048, respectively). However, the combinations of
CYP1A1
(AA) and
CYP2D6
(CC) genotypes decreased risk of HNC (OR 0.20;
P
= 0.006). Genetic polymorphisms in
CYP1A1
and
CYP2D6
may significantly associate with HNC in the Tunisian population. The results of this study suggest a possible gene–environment interaction for certain carcinogen metabolizing enzymes, but larger studies that fully evaluate the interaction are needed.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24449363</pmid><doi>10.1007/s11033-014-3117-6</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-4851 |
| ispartof | Molecular biology reports, 2014-04, Vol.41 (4), p.2591-2600 |
| issn | 0301-4851 1573-4978 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Alleles Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Case-Control Studies Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP2D6 - genetics Epistasis, Genetic Female Gene-Environment Interaction Genetic Association Studies Genetic Predisposition to Disease Genotype Genotype & phenotype Head & neck cancer Head and Neck Neoplasms - epidemiology Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Histology Humans Life Sciences Male Middle Aged Molecular biology Morphology Odds Ratio Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide Population genetics Risk Factors Tunisia Young Adult |
| title | Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients |
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