Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats

Recent evidence indicates that severe abnormalities in brain glucose/energy metabolism and insulin signaling have been documented to take a pivotal role in early sporadic Alzheimer’s disease pathology. It has been reported that naringenin (NAR), derived from citrus aurantium, exhibits antioxidant po...

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Veröffentlicht in:	Neurological sciences 2014-05, Vol.35 (5), p.741-751
Hauptverfasser:	Yang, Wenqing, Ma, Jing, Liu, Zheng, Lu, Yongliang, Hu, Bin, Yu, Huarong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - metabolism Animals Blood Glucose - drug effects Brain - drug effects Brain - physiopathology Citrus aurantium Cognition - drug effects Cognition - physiology Cognition Disorders - drug therapy Cognition Disorders - physiopathology Dementia Dementia - drug therapy Dementia - physiopathology Disease Models, Animal Dose-Response Relationship, Drug Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Infusions, Intraventricular Insulins - metabolism Male Maze Learning - drug effects Maze Learning - physiology Medicine Medicine & Public Health Neurology Neuroradiology Neurosciences Neurosurgery Original Article Peptide Fragments - metabolism Psychiatry Random Allocation Rats, Sprague-Dawley Receptor, Insulin - metabolism RNA, Messenger - metabolism Spatial Memory - drug effects Spatial Memory - physiology Streptozocin tau Proteins - metabolism
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