Fabrication of 3‑Dimensional Cellular Constructs via Microstereolithography Using a Simple, Three-Component, Poly(Ethylene Glycol) Acrylate-Based System
A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be m...
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| Veröffentlicht in: | Biomacromolecules 2013-01, Vol.14 (1), p.186-192 |
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| container_title | Biomacromolecules |
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| creator | Leigh, Simon J Gilbert, Hamish T. J Barker, Ian A Becker, Jan M Richardson, Stephen M Hoyland, Judith A Covington, James A Dove, Andrew P |
| description | A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be manufactured. Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications. |
| doi_str_mv | 10.1021/bm3015736 |
| format | Article |
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These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.</description><identifier>ISSN: 1525-7797</identifier><identifier>EISSN: 1526-4602</identifier><identifier>DOI: 10.1021/bm3015736</identifier><identifier>PMID: 23167767</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Acrylates - administration & dosage ; Acrylates - chemistry ; Adult ; Aged ; Animals ; Applied sciences ; Biological and medical sciences ; Cell Differentiation - drug effects ; Cell Differentiation - physiology ; Cells, Cultured ; Computer-Aided Design ; Dogs ; Exact sciences and technology ; Female ; Humans ; Male ; Medical sciences ; Mesenchymal Stromal Cells - drug effects ; Mesenchymal Stromal Cells - physiology ; Physicochemistry of polymers ; Polyethylene Glycols - administration & dosage ; Polyethylene Glycols - chemistry ; Polymerization ; Polymers and radiations ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. 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Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.</description><subject>Acrylates - administration & dosage</subject><subject>Acrylates - chemistry</subject><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>Cells, Cultured</subject><subject>Computer-Aided Design</subject><subject>Dogs</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesenchymal Stromal Cells - drug effects</subject><subject>Mesenchymal Stromal Cells - physiology</subject><subject>Physicochemistry of polymers</subject><subject>Polyethylene Glycols - administration & dosage</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymerization</subject><subject>Polymers and radiations</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. 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| subjects | Acrylates - administration & dosage Acrylates - chemistry Adult Aged Animals Applied sciences Biological and medical sciences Cell Differentiation - drug effects Cell Differentiation - physiology Cells, Cultured Computer-Aided Design Dogs Exact sciences and technology Female Humans Male Medical sciences Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - physiology Physicochemistry of polymers Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Polymerization Polymers and radiations Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tissue Engineering - instrumentation Tissue Engineering - methods |
| title | Fabrication of 3‑Dimensional Cellular Constructs via Microstereolithography Using a Simple, Three-Component, Poly(Ethylene Glycol) Acrylate-Based System |
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