Genome-Wide Mouse Mutagenesis Reveals CD45-Mediated T Cell Function as Critical in Protective Immunity to HSV-1: e1003637

Herpes simplex encephalitis (HSE) is a lethal neurological disease resulting from infection with Herpes Simplex Virus 1 (HSV-1). Loss-of-function mutations in the UNC93B1, TLR3, TRIF, TRAF3, and TBK1 genes have been associated with a human genetic predisposition to HSE, demonstrating the UNC93B-TLR3...

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Veröffentlicht in:	PLoS pathogens 2013-09, Vol.9 (9)
Hauptverfasser:	Caignard, Grégory, Leiva-Torres, Gabriel A, Leney-Greene, Michael, Charbonneau, Benoit, Dumaine, Anne, Fodil-Cornu, Nassima, Pyzik, Michal, Cingolani, Pablo, Schwartzentruber, Jeremy, Dupaul-Chicoine, Jeremy, Guo, Huaijian, Saleh, Maya, Veillette, André, Lathrop, Marc, Blanchette, Mathieu, Majewski, Jacek, Pearson, Angela, Vidal, Silvia M
Format:	Artikel
Sprache:	eng
Schlagworte:	Genes Infections Medical research Mutation Rodents
Online-Zugang:	Volltext
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