Recombinant Human Fibrinogen That Produces Thick Fibrin Fibers with Increased Wound Adhesion and Clot Density

Human fibrinogen is a biomaterial used in surgical tissue sealants, scaffolding for tissue engineering, and wound healing. Here we report on the post-translational structure and functionality of recombinant human FI (rFI) made at commodity levels in the milk of transgenic dairy cows. Relative to pla...

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Veröffentlicht in:	Biomacromolecules 2013-01, Vol.14 (1), p.169-178
Hauptverfasser:	Calcaterra, Jennifer, Van Cott, Kevin E, Butler, Stephen P, Gil, Geun Cheol, Germano, Marta, van Veen, Harrie A, Nelson, Kay, Forsberg, Erik J, Carlson, Mark A, Velander, William H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Animals, Genetically Modified Biological and medical sciences Biotechnology Blood Coagulation - drug effects Blood Coagulation - physiology Cattle Coagulation factors Fibrin - administration & dosage Fibrin - chemical synthesis Fibrinogen - administration & dosage Fibrinogen - chemical synthesis Fundamental and applied biological sciences. Psychology Glycoproteins Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Production of active biomolecules Proteins Recombinant Proteins - administration & dosage Recombinant Proteins - chemical synthesis Recombinant Proteins - chemistry Swine Wound Healing - drug effects Wound Healing - physiology
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