Aptamer-Capped Multifunctional Mesoporous Strontium Hydroxyapatite Nanovehicle for Cancer-Cell-Responsive Drug Delivery and Imaging

A novel cancer-cells-triggered controlled-release gadolinium-doped luminescent and mesoporous strontium hydroxyapatite nanorods (designated as Gd:SrHap nanorods) system using cell-type-specific aptamers as caps has been constructed. Aptamers behave as a dual-functional molecule that acts as not only...

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Veröffentlicht in:	Biomacromolecules 2012-12, Vol.13 (12), p.4257-4263
Hauptverfasser:	Li, Zhenhua, Liu, Zhen, Yin, Meili, Yang, Xinjian, Yuan, Qinghai, Ren, Jinsong, Qu, Xiaogang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Aptamers, Nucleotide - pharmacology Biological and medical sciences Chemotherapy Contrast media. Radiopharmaceuticals Doxorubicin - pharmacology Drug Carriers - chemical synthesis Electrophoresis, Agar Gel Gadolinium - pharmacology Humans Hydroxyapatites - chemistry Magnetic Resonance Imaging MCF-7 Cells Medical sciences Mice Nanotechnology Nanotubes - chemistry NIH 3T3 Cells Pharmacology. Drug treatments Strontium - chemistry
Online-Zugang:	Volltext
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