Aptamer-Capped Multifunctional Mesoporous Strontium Hydroxyapatite Nanovehicle for Cancer-Cell-Responsive Drug Delivery and Imaging
A novel cancer-cells-triggered controlled-release gadolinium-doped luminescent and mesoporous strontium hydroxyapatite nanorods (designated as Gd:SrHap nanorods) system using cell-type-specific aptamers as caps has been constructed. Aptamers behave as a dual-functional molecule that acts as not only...
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| Veröffentlicht in: | Biomacromolecules 2012-12, Vol.13 (12), p.4257-4263 |
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| container_title | Biomacromolecules |
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| creator | Li, Zhenhua Liu, Zhen Yin, Meili Yang, Xinjian Yuan, Qinghai Ren, Jinsong Qu, Xiaogang |
| description | A novel cancer-cells-triggered controlled-release gadolinium-doped luminescent and mesoporous strontium hydroxyapatite nanorods (designated as Gd:SrHap nanorods) system using cell-type-specific aptamers as caps has been constructed. Aptamers behave as a dual-functional molecule that acts as not only a lid but also a targeted molecular that can be used in an effective way for therapeutically special cancer cells. After incubated with cancer cells, for example, MCF-7 cells, the doxorubicin-loaded and aptamer-capped Gd:SrHap nanorods (designated as Gd:SrHap-Dox-aptamer) can be internalized into MCF-7 cells, resulting in the pore opening and drug releasing. Furthermore, the high biocompatibility and biodegradability Gd:SrHap nanorods with blue autofluorescence and paramagnetism could serve as a good contrast agent of targeting fluorescence and magnetic resonance imaging. We envision that this Gd:SrHap system could play a significant role in developing new generations of site-selective, controlled-release delivery and interactive sensory nanodevices. |
| doi_str_mv | 10.1021/bm301563q |
| format | Article |
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Aptamers behave as a dual-functional molecule that acts as not only a lid but also a targeted molecular that can be used in an effective way for therapeutically special cancer cells. After incubated with cancer cells, for example, MCF-7 cells, the doxorubicin-loaded and aptamer-capped Gd:SrHap nanorods (designated as Gd:SrHap-Dox-aptamer) can be internalized into MCF-7 cells, resulting in the pore opening and drug releasing. Furthermore, the high biocompatibility and biodegradability Gd:SrHap nanorods with blue autofluorescence and paramagnetism could serve as a good contrast agent of targeting fluorescence and magnetic resonance imaging. We envision that this Gd:SrHap system could play a significant role in developing new generations of site-selective, controlled-release delivery and interactive sensory nanodevices.</description><identifier>ISSN: 1525-7797</identifier><identifier>EISSN: 1526-4602</identifier><identifier>DOI: 10.1021/bm301563q</identifier><identifier>PMID: 23140615</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Antineoplastic agents ; Aptamers, Nucleotide - pharmacology ; Biological and medical sciences ; Chemotherapy ; Contrast media. Radiopharmaceuticals ; Doxorubicin - pharmacology ; Drug Carriers - chemical synthesis ; Electrophoresis, Agar Gel ; Gadolinium - pharmacology ; Humans ; Hydroxyapatites - chemistry ; Magnetic Resonance Imaging ; MCF-7 Cells ; Medical sciences ; Mice ; Nanotechnology ; Nanotubes - chemistry ; NIH 3T3 Cells ; Pharmacology. Drug treatments ; Strontium - chemistry</subject><ispartof>Biomacromolecules, 2012-12, Vol.13 (12), p.4257-4263</ispartof><rights>Copyright © 2012 American Chemical Society</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a378t-fbd888d83ac9ce0bcafb042d00712093f8f68df430096040484ea8f3c631abcf3</citedby><cites>FETCH-LOGICAL-a378t-fbd888d83ac9ce0bcafb042d00712093f8f68df430096040484ea8f3c631abcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/bm301563q$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/bm301563q$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26726945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23140615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Zhenhua</creatorcontrib><creatorcontrib>Liu, Zhen</creatorcontrib><creatorcontrib>Yin, Meili</creatorcontrib><creatorcontrib>Yang, Xinjian</creatorcontrib><creatorcontrib>Yuan, Qinghai</creatorcontrib><creatorcontrib>Ren, Jinsong</creatorcontrib><creatorcontrib>Qu, Xiaogang</creatorcontrib><title>Aptamer-Capped Multifunctional Mesoporous Strontium Hydroxyapatite Nanovehicle for Cancer-Cell-Responsive Drug Delivery and Imaging</title><title>Biomacromolecules</title><addtitle>Biomacromolecules</addtitle><description>A novel cancer-cells-triggered controlled-release gadolinium-doped luminescent and mesoporous strontium hydroxyapatite nanorods (designated as Gd:SrHap nanorods) system using cell-type-specific aptamers as caps has been constructed. Aptamers behave as a dual-functional molecule that acts as not only a lid but also a targeted molecular that can be used in an effective way for therapeutically special cancer cells. After incubated with cancer cells, for example, MCF-7 cells, the doxorubicin-loaded and aptamer-capped Gd:SrHap nanorods (designated as Gd:SrHap-Dox-aptamer) can be internalized into MCF-7 cells, resulting in the pore opening and drug releasing. Furthermore, the high biocompatibility and biodegradability Gd:SrHap nanorods with blue autofluorescence and paramagnetism could serve as a good contrast agent of targeting fluorescence and magnetic resonance imaging. We envision that this Gd:SrHap system could play a significant role in developing new generations of site-selective, controlled-release delivery and interactive sensory nanodevices.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Aptamers, Nucleotide - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Electrophoresis, Agar Gel</subject><subject>Gadolinium - pharmacology</subject><subject>Humans</subject><subject>Hydroxyapatites - chemistry</subject><subject>Magnetic Resonance Imaging</subject><subject>MCF-7 Cells</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Nanotechnology</subject><subject>Nanotubes - chemistry</subject><subject>NIH 3T3 Cells</subject><subject>Pharmacology. Drug treatments</subject><subject>Strontium - chemistry</subject><issn>1525-7797</issn><issn>1526-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQhS0EoqWw4A8gb5DKIjB-xHGW1S3QSi1IPNbRxLEvrhI7tZOKu-aP49JLYYHEambx6cyccwh5zuA1A87e9JMAVitx_YAcspqrSirgD3_tddU0bXNAnuR8BQCtkPVjcsAFk6BYfUh-nMwLTjZVG5xnO9DLdVy8W4NZfAw40kub4xxTXDP9vKQYFr9O9Gw3pPh9hzMufrH0A4Z4Y795M1rqYqIbDOZW0Y5j9cnmOYbsbyw9TeuWntqx7GlHMQz0fMKtD9un5JHDMdtn-3lEvr57-2VzVl18fH--ObmoUDR6qVw_aK0HLdC0xkJv0PUg-QDQMF6cOe2UHpwUxaYCCVJLi9oJowTD3jhxRI7vdOcUr1ebl27y2ZQvMdhisCtxSQm1UPB_lIsGWiaAF_TVHWpSzDlZ183JT5h2HYPutp7uvp7CvtjLrv1kh3vydx8FeLkHMBscXSpR-vyHUw1XrfyLQ5O7q7im0lX-x8GfQralcQ</recordid><startdate>20121210</startdate><enddate>20121210</enddate><creator>Li, Zhenhua</creator><creator>Liu, Zhen</creator><creator>Yin, Meili</creator><creator>Yang, Xinjian</creator><creator>Yuan, Qinghai</creator><creator>Ren, Jinsong</creator><creator>Qu, Xiaogang</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20121210</creationdate><title>Aptamer-Capped Multifunctional Mesoporous Strontium Hydroxyapatite Nanovehicle for Cancer-Cell-Responsive Drug Delivery and Imaging</title><author>Li, Zhenhua ; Liu, Zhen ; Yin, Meili ; Yang, Xinjian ; Yuan, Qinghai ; Ren, Jinsong ; Qu, Xiaogang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a378t-fbd888d83ac9ce0bcafb042d00712093f8f68df430096040484ea8f3c631abcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Aptamers, Nucleotide - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Electrophoresis, Agar Gel</topic><topic>Gadolinium - pharmacology</topic><topic>Humans</topic><topic>Hydroxyapatites - chemistry</topic><topic>Magnetic Resonance Imaging</topic><topic>MCF-7 Cells</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Nanotechnology</topic><topic>Nanotubes - chemistry</topic><topic>NIH 3T3 Cells</topic><topic>Pharmacology. Drug treatments</topic><topic>Strontium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhenhua</creatorcontrib><creatorcontrib>Liu, Zhen</creatorcontrib><creatorcontrib>Yin, Meili</creatorcontrib><creatorcontrib>Yang, Xinjian</creatorcontrib><creatorcontrib>Yuan, Qinghai</creatorcontrib><creatorcontrib>Ren, Jinsong</creatorcontrib><creatorcontrib>Qu, Xiaogang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biomacromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhenhua</au><au>Liu, Zhen</au><au>Yin, Meili</au><au>Yang, Xinjian</au><au>Yuan, Qinghai</au><au>Ren, Jinsong</au><au>Qu, Xiaogang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aptamer-Capped Multifunctional Mesoporous Strontium Hydroxyapatite Nanovehicle for Cancer-Cell-Responsive Drug Delivery and Imaging</atitle><jtitle>Biomacromolecules</jtitle><addtitle>Biomacromolecules</addtitle><date>2012-12-10</date><risdate>2012</risdate><volume>13</volume><issue>12</issue><spage>4257</spage><epage>4263</epage><pages>4257-4263</pages><issn>1525-7797</issn><eissn>1526-4602</eissn><abstract>A novel cancer-cells-triggered controlled-release gadolinium-doped luminescent and mesoporous strontium hydroxyapatite nanorods (designated as Gd:SrHap nanorods) system using cell-type-specific aptamers as caps has been constructed. Aptamers behave as a dual-functional molecule that acts as not only a lid but also a targeted molecular that can be used in an effective way for therapeutically special cancer cells. After incubated with cancer cells, for example, MCF-7 cells, the doxorubicin-loaded and aptamer-capped Gd:SrHap nanorods (designated as Gd:SrHap-Dox-aptamer) can be internalized into MCF-7 cells, resulting in the pore opening and drug releasing. Furthermore, the high biocompatibility and biodegradability Gd:SrHap nanorods with blue autofluorescence and paramagnetism could serve as a good contrast agent of targeting fluorescence and magnetic resonance imaging. We envision that this Gd:SrHap system could play a significant role in developing new generations of site-selective, controlled-release delivery and interactive sensory nanodevices.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>23140615</pmid><doi>10.1021/bm301563q</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antineoplastic agents Aptamers, Nucleotide - pharmacology Biological and medical sciences Chemotherapy Contrast media. Radiopharmaceuticals Doxorubicin - pharmacology Drug Carriers - chemical synthesis Electrophoresis, Agar Gel Gadolinium - pharmacology Humans Hydroxyapatites - chemistry Magnetic Resonance Imaging MCF-7 Cells Medical sciences Mice Nanotechnology Nanotubes - chemistry NIH 3T3 Cells Pharmacology. Drug treatments Strontium - chemistry |
| title | Aptamer-Capped Multifunctional Mesoporous Strontium Hydroxyapatite Nanovehicle for Cancer-Cell-Responsive Drug Delivery and Imaging |
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