Ionically Gelled Alginate Foams: Physical Properties Controlled by Operational and Macromolecular Parameters
Alginates in the format of scaffolds provide important functions as materials for cell encapsulation, drug delivery, tissue engineering and wound healing among others. The method for preparation of alginate-based foams presented here is based on homogeneous, ionotropic gelation of aerated alginate s...
Gespeichert in:
| Veröffentlicht in: | Biomacromolecules 2012-11, Vol.13 (11), p.3703-3710 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3710 |
|---|---|
| container_issue | 11 |
| container_start_page | 3703 |
| container_title | Biomacromolecules |
| container_volume | 13 |
| creator | Andersen, Therese Melvik, Jan Egil Gåserød, Olav Alsberg, Eben Christensen, Bjørn E |
| description | Alginates in the format of scaffolds provide important functions as materials for cell encapsulation, drug delivery, tissue engineering and wound healing among others. The method for preparation of alginate-based foams presented here is based on homogeneous, ionotropic gelation of aerated alginate solutions, followed by air drying. The method allows higher flexibility and better control of the pore structure, hydration properties and mechanical integrity compared to foams prepared by other techniques. The main variables for tailoring hydrogel properties include operational parameters such as degree of aeration and mixing times and concentration of alginate, as well as macromolecular properties such as the type of alginate (chemical composition and molecular weight distribution). Exposure of foams to γ-irradiation resulted in a dose-dependent (0–30 kGy) reduction in molecular weight of the alginate and a corresponding reduction in tensile strength of the foams. |
| doi_str_mv | 10.1021/bm301194f |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1524405190</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1524405190</sourcerecordid><originalsourceid>FETCH-LOGICAL-a444t-cbcf615d42a788e19cced11863ca7c98af7808ea1239056f579d75488cebc47a3</originalsourceid><addsrcrecordid>eNqF0U1P3DAQBmALtQIKPfAHkC-V2kNaT2LHdm9oVT4kKvZAz9HEmUCQE2_t5LD_HgMLXCr1NNbo0VjzDmMnIL6DKOFHO1YCwMp-jx2CKutC1qL88PxWhdZWH7BPKT0IIWwl1T47KEtrwVh5yPxVmAaH3m_5BXlPHT_zd8OEM_HzgGP6ydf32_Qk-DqGDcV5oMRXYZpjeObtlt_kNs5DmDLCqeO_0cUwBk9u8Rj5GiOONFNMx-xjjz7R5109Yn_Of92uLovrm4ur1dl1gVLKuXCt62tQnSxRG0NgnaMOwNSVQ-2swV4bYQihrKxQda-07bSSxjhqndRYHbGvL3M3MfxdKM3NOCSX18OJwpKanIuUQoEV_6egQAtZSZ3ptxeat0spUt9s4jBi3DYgmqc7NG93yPZ0N3ZpR-re5GvwGXzZAUw53D7i5Ib07upaVKWFd4cuNQ9hiTnk9I8PHwEkGJwt</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1151704347</pqid></control><display><type>article</type><title>Ionically Gelled Alginate Foams: Physical Properties Controlled by Operational and Macromolecular Parameters</title><source>MEDLINE</source><source>ACS Publications</source><creator>Andersen, Therese ; Melvik, Jan Egil ; Gåserød, Olav ; Alsberg, Eben ; Christensen, Bjørn E</creator><creatorcontrib>Andersen, Therese ; Melvik, Jan Egil ; Gåserød, Olav ; Alsberg, Eben ; Christensen, Bjørn E</creatorcontrib><description>Alginates in the format of scaffolds provide important functions as materials for cell encapsulation, drug delivery, tissue engineering and wound healing among others. The method for preparation of alginate-based foams presented here is based on homogeneous, ionotropic gelation of aerated alginate solutions, followed by air drying. The method allows higher flexibility and better control of the pore structure, hydration properties and mechanical integrity compared to foams prepared by other techniques. The main variables for tailoring hydrogel properties include operational parameters such as degree of aeration and mixing times and concentration of alginate, as well as macromolecular properties such as the type of alginate (chemical composition and molecular weight distribution). Exposure of foams to γ-irradiation resulted in a dose-dependent (0–30 kGy) reduction in molecular weight of the alginate and a corresponding reduction in tensile strength of the foams.</description><identifier>ISSN: 1525-7797</identifier><identifier>EISSN: 1526-4602</identifier><identifier>DOI: 10.1021/bm301194f</identifier><identifier>PMID: 22991894</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Alginates - chemistry ; Applied sciences ; Biocompatible Materials - chemistry ; Biological and medical sciences ; Biopolymers - chemistry ; Cellular ; Drug Carriers ; Exact sciences and technology ; Forms of application and semi-finished materials ; Gels - chemistry ; Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry ; Medical sciences ; Molecular Weight ; Polymer industry, paints, wood ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology of polymers ; Technology. Biomaterials. Equipments ; Tensile Strength ; Tissue Engineering ; Tissue Scaffolds ; Wound Healing</subject><ispartof>Biomacromolecules, 2012-11, Vol.13 (11), p.3703-3710</ispartof><rights>Copyright © 2012 American Chemical Society</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a444t-cbcf615d42a788e19cced11863ca7c98af7808ea1239056f579d75488cebc47a3</citedby><cites>FETCH-LOGICAL-a444t-cbcf615d42a788e19cced11863ca7c98af7808ea1239056f579d75488cebc47a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/bm301194f$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/bm301194f$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2764,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26603291$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22991894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andersen, Therese</creatorcontrib><creatorcontrib>Melvik, Jan Egil</creatorcontrib><creatorcontrib>Gåserød, Olav</creatorcontrib><creatorcontrib>Alsberg, Eben</creatorcontrib><creatorcontrib>Christensen, Bjørn E</creatorcontrib><title>Ionically Gelled Alginate Foams: Physical Properties Controlled by Operational and Macromolecular Parameters</title><title>Biomacromolecules</title><addtitle>Biomacromolecules</addtitle><description>Alginates in the format of scaffolds provide important functions as materials for cell encapsulation, drug delivery, tissue engineering and wound healing among others. The method for preparation of alginate-based foams presented here is based on homogeneous, ionotropic gelation of aerated alginate solutions, followed by air drying. The method allows higher flexibility and better control of the pore structure, hydration properties and mechanical integrity compared to foams prepared by other techniques. The main variables for tailoring hydrogel properties include operational parameters such as degree of aeration and mixing times and concentration of alginate, as well as macromolecular properties such as the type of alginate (chemical composition and molecular weight distribution). Exposure of foams to γ-irradiation resulted in a dose-dependent (0–30 kGy) reduction in molecular weight of the alginate and a corresponding reduction in tensile strength of the foams.</description><subject>Alginates - chemistry</subject><subject>Applied sciences</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biological and medical sciences</subject><subject>Biopolymers - chemistry</subject><subject>Cellular</subject><subject>Drug Carriers</subject><subject>Exact sciences and technology</subject><subject>Forms of application and semi-finished materials</subject><subject>Gels - chemistry</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry</subject><subject>Medical sciences</subject><subject>Molecular Weight</subject><subject>Polymer industry, paints, wood</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology of polymers</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Tensile Strength</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds</subject><subject>Wound Healing</subject><issn>1525-7797</issn><issn>1526-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1P3DAQBmALtQIKPfAHkC-V2kNaT2LHdm9oVT4kKvZAz9HEmUCQE2_t5LD_HgMLXCr1NNbo0VjzDmMnIL6DKOFHO1YCwMp-jx2CKutC1qL88PxWhdZWH7BPKT0IIWwl1T47KEtrwVh5yPxVmAaH3m_5BXlPHT_zd8OEM_HzgGP6ydf32_Qk-DqGDcV5oMRXYZpjeObtlt_kNs5DmDLCqeO_0cUwBk9u8Rj5GiOONFNMx-xjjz7R5109Yn_Of92uLovrm4ur1dl1gVLKuXCt62tQnSxRG0NgnaMOwNSVQ-2swV4bYQihrKxQda-07bSSxjhqndRYHbGvL3M3MfxdKM3NOCSX18OJwpKanIuUQoEV_6egQAtZSZ3ptxeat0spUt9s4jBi3DYgmqc7NG93yPZ0N3ZpR-re5GvwGXzZAUw53D7i5Ib07upaVKWFd4cuNQ9hiTnk9I8PHwEkGJwt</recordid><startdate>20121112</startdate><enddate>20121112</enddate><creator>Andersen, Therese</creator><creator>Melvik, Jan Egil</creator><creator>Gåserød, Olav</creator><creator>Alsberg, Eben</creator><creator>Christensen, Bjørn E</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20121112</creationdate><title>Ionically Gelled Alginate Foams: Physical Properties Controlled by Operational and Macromolecular Parameters</title><author>Andersen, Therese ; Melvik, Jan Egil ; Gåserød, Olav ; Alsberg, Eben ; Christensen, Bjørn E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a444t-cbcf615d42a788e19cced11863ca7c98af7808ea1239056f579d75488cebc47a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alginates - chemistry</topic><topic>Applied sciences</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biological and medical sciences</topic><topic>Biopolymers - chemistry</topic><topic>Cellular</topic><topic>Drug Carriers</topic><topic>Exact sciences and technology</topic><topic>Forms of application and semi-finished materials</topic><topic>Gels - chemistry</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry</topic><topic>Medical sciences</topic><topic>Molecular Weight</topic><topic>Polymer industry, paints, wood</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology of polymers</topic><topic>Technology. Biomaterials. Equipments</topic><topic>Tensile Strength</topic><topic>Tissue Engineering</topic><topic>Tissue Scaffolds</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andersen, Therese</creatorcontrib><creatorcontrib>Melvik, Jan Egil</creatorcontrib><creatorcontrib>Gåserød, Olav</creatorcontrib><creatorcontrib>Alsberg, Eben</creatorcontrib><creatorcontrib>Christensen, Bjørn E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biomacromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andersen, Therese</au><au>Melvik, Jan Egil</au><au>Gåserød, Olav</au><au>Alsberg, Eben</au><au>Christensen, Bjørn E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ionically Gelled Alginate Foams: Physical Properties Controlled by Operational and Macromolecular Parameters</atitle><jtitle>Biomacromolecules</jtitle><addtitle>Biomacromolecules</addtitle><date>2012-11-12</date><risdate>2012</risdate><volume>13</volume><issue>11</issue><spage>3703</spage><epage>3710</epage><pages>3703-3710</pages><issn>1525-7797</issn><eissn>1526-4602</eissn><abstract>Alginates in the format of scaffolds provide important functions as materials for cell encapsulation, drug delivery, tissue engineering and wound healing among others. The method for preparation of alginate-based foams presented here is based on homogeneous, ionotropic gelation of aerated alginate solutions, followed by air drying. The method allows higher flexibility and better control of the pore structure, hydration properties and mechanical integrity compared to foams prepared by other techniques. The main variables for tailoring hydrogel properties include operational parameters such as degree of aeration and mixing times and concentration of alginate, as well as macromolecular properties such as the type of alginate (chemical composition and molecular weight distribution). Exposure of foams to γ-irradiation resulted in a dose-dependent (0–30 kGy) reduction in molecular weight of the alginate and a corresponding reduction in tensile strength of the foams.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>22991894</pmid><doi>10.1021/bm301194f</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1525-7797 |
| ispartof | Biomacromolecules, 2012-11, Vol.13 (11), p.3703-3710 |
| issn | 1525-7797 1526-4602 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1524405190 |
| source | MEDLINE; ACS Publications |
| subjects | Alginates - chemistry Applied sciences Biocompatible Materials - chemistry Biological and medical sciences Biopolymers - chemistry Cellular Drug Carriers Exact sciences and technology Forms of application and semi-finished materials Gels - chemistry Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Medical sciences Molecular Weight Polymer industry, paints, wood Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology of polymers Technology. Biomaterials. Equipments Tensile Strength Tissue Engineering Tissue Scaffolds Wound Healing |
| title | Ionically Gelled Alginate Foams: Physical Properties Controlled by Operational and Macromolecular Parameters |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T19%3A32%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ionically%20Gelled%20Alginate%20Foams:%20Physical%20Properties%20Controlled%20by%20Operational%20and%20Macromolecular%20Parameters&rft.jtitle=Biomacromolecules&rft.au=Andersen,%20Therese&rft.date=2012-11-12&rft.volume=13&rft.issue=11&rft.spage=3703&rft.epage=3710&rft.pages=3703-3710&rft.issn=1525-7797&rft.eissn=1526-4602&rft_id=info:doi/10.1021/bm301194f&rft_dat=%3Cproquest_cross%3E1524405190%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1151704347&rft_id=info:pmid/22991894&rfr_iscdi=true |