Expression of Smac induced by the Egr1 promoter enhances the radiosensitivity of breast cancer cells

Breast cancer is one of the most prevalent cancers worldwide. Moreover, despite advances in antineoplastic therapies, induction of tumor cell death without off-target cytotoxicity remains a challenge. However, recent developments in localized radiotherapy and gene therapy have provided an opportunit...

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Veröffentlicht in:	Cancer gene therapy 2014-04, Vol.21 (4), p.142-149
Hauptverfasser:	Li, Z-L, Liang, S, Wang, Z-C, Li, Y-B, Guo, C-X, Fang, F, Gong, S-L, Lin, C-H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/61/201 631/67/1059/485 631/67/1347 Adenoviridae - genetics Apoptosis Apoptosis - genetics Apoptosis - radiation effects Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - therapy Cancer therapies Care and treatment Cell cycle Cell death Cell Line, Tumor Cell Survival Cell viability Combined Modality Therapy Cytotoxicity DIABLO protein Early Growth Response Protein 1 - genetics Early Growth Response Protein 1 - metabolism EGR-1 protein Female Gene Expression Gene Therapy Genetic aspects Genetic Therapy - methods Genetic Vectors - genetics Health aspects Humans Ionizing radiation MCF-7 Cells Oligopeptides - biosynthesis Oligopeptides - genetics original-article Promoter Regions, Genetic Proteins Radiation therapy Radiation Tolerance - genetics Radiosensitivity Radiotherapy Transfection Tumor cell lines Tumor cells
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