Polymorphisms of the bone morphogenetic protein 7 gene (BMP7) and association analysis with sow productive traits
Bone morphological protein 7 (BMP7) has been proposed to be an osteoinductive protein. Recent data have shown that BMP7 also plays a crucial role in the growth and development, and physiological function of reproductive system. To date, studies have shown an association between the BMP gene family a...
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| Veröffentlicht in: | Animal reproduction science 2013-11, Vol.142 (1-2), p.56-62 |
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| creator | Feng, Xue Xie, Shu-Yu Zhou, Jian-She Sun, Gui-Rong Lu, Peng Li, Ming |
| description | Bone morphological protein 7 (BMP7) has been proposed to be an osteoinductive protein. Recent data have shown that BMP7 also plays a crucial role in the growth and development, and physiological function of reproductive system. To date, studies have shown an association between the BMP gene family and reproduction in many populations, but few studies have completely described this association in sow. In the present study, three sow breeds were screened out to investigate the genetic effects of the BMP7 gene. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing, three single nucleotide polymorphisms (SNPs) (g.35161T>C, g.35175T>C and g.35216C>T) were identified in intron 2 of the BMP7 gene. Associations between the three SNPs and the number of piglet born alive (NBA), litter weight at birth (LBW), total number of piglet born (TNB) and litter weight at 21 days were analyzed using association analysis. Among the three SNPs, g.35161T>C was significantly associated with NBA and LBW (p |
| doi_str_mv | 10.1016/j.anireprosci.2013.08.011 |
| format | Article |
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Recent data have shown that BMP7 also plays a crucial role in the growth and development, and physiological function of reproductive system. To date, studies have shown an association between the BMP gene family and reproduction in many populations, but few studies have completely described this association in sow. In the present study, three sow breeds were screened out to investigate the genetic effects of the BMP7 gene. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing, three single nucleotide polymorphisms (SNPs) (g.35161T>C, g.35175T>C and g.35216C>T) were identified in intron 2 of the BMP7 gene. Associations between the three SNPs and the number of piglet born alive (NBA), litter weight at birth (LBW), total number of piglet born (TNB) and litter weight at 21 days were analyzed using association analysis. Among the three SNPs, g.35161T>C was significantly associated with NBA and LBW (p<0.05), and the litter weight at 21 days (p<0.01). These results suggest that g.35161T>C is a potential candidate gene locus for litter size traits and the BMP7 gene might be associated with the quantitative trait locus (QTL) controlling the litter size. These data will provide a background for more extensive characterization of the BMP7 gene.</description><identifier>ISSN: 0378-4320</identifier><identifier>EISSN: 1873-2232</identifier><identifier>DOI: 10.1016/j.anireprosci.2013.08.011</identifier><identifier>PMID: 24035155</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; birth weight ; BMP7 gene ; Bone Morphogenetic Protein 7 - genetics ; Bone Morphogenetic Protein 7 - metabolism ; bone morphogenetic proteins ; breeds ; Female ; Gene Expression Regulation - physiology ; genes ; Genotype ; growth and development ; Intron 2 ; litter size ; Litter Size - genetics ; litter weight ; loci ; piglets ; Polymorphism ; Polymorphism, Single Nucleotide - physiology ; quantitative trait loci ; Reproduction - genetics ; reproductive system ; Reproductive trait ; sequence analysis ; single nucleotide polymorphism ; Sow ; sows ; Swine - genetics ; Swine - physiology</subject><ispartof>Animal reproduction science, 2013-11, Vol.142 (1-2), p.56-62</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-c718d727994d16424af435abb5ea142eb1a95e953f691f85fe99ebc11bd75123</citedby><cites>FETCH-LOGICAL-c458t-c718d727994d16424af435abb5ea142eb1a95e953f691f85fe99ebc11bd75123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anireprosci.2013.08.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24035155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Xue</creatorcontrib><creatorcontrib>Xie, Shu-Yu</creatorcontrib><creatorcontrib>Zhou, Jian-She</creatorcontrib><creatorcontrib>Sun, Gui-Rong</creatorcontrib><creatorcontrib>Lu, Peng</creatorcontrib><creatorcontrib>Li, Ming</creatorcontrib><title>Polymorphisms of the bone morphogenetic protein 7 gene (BMP7) and association analysis with sow productive traits</title><title>Animal reproduction science</title><addtitle>Anim Reprod Sci</addtitle><description>Bone morphological protein 7 (BMP7) has been proposed to be an osteoinductive protein. Recent data have shown that BMP7 also plays a crucial role in the growth and development, and physiological function of reproductive system. To date, studies have shown an association between the BMP gene family and reproduction in many populations, but few studies have completely described this association in sow. In the present study, three sow breeds were screened out to investigate the genetic effects of the BMP7 gene. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing, three single nucleotide polymorphisms (SNPs) (g.35161T>C, g.35175T>C and g.35216C>T) were identified in intron 2 of the BMP7 gene. Associations between the three SNPs and the number of piglet born alive (NBA), litter weight at birth (LBW), total number of piglet born (TNB) and litter weight at 21 days were analyzed using association analysis. Among the three SNPs, g.35161T>C was significantly associated with NBA and LBW (p<0.05), and the litter weight at 21 days (p<0.01). These results suggest that g.35161T>C is a potential candidate gene locus for litter size traits and the BMP7 gene might be associated with the quantitative trait locus (QTL) controlling the litter size. These data will provide a background for more extensive characterization of the BMP7 gene.</description><subject>Animals</subject><subject>birth weight</subject><subject>BMP7 gene</subject><subject>Bone Morphogenetic Protein 7 - genetics</subject><subject>Bone Morphogenetic Protein 7 - metabolism</subject><subject>bone morphogenetic proteins</subject><subject>breeds</subject><subject>Female</subject><subject>Gene Expression Regulation - physiology</subject><subject>genes</subject><subject>Genotype</subject><subject>growth and development</subject><subject>Intron 2</subject><subject>litter size</subject><subject>Litter Size - genetics</subject><subject>litter weight</subject><subject>loci</subject><subject>piglets</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - physiology</subject><subject>quantitative trait loci</subject><subject>Reproduction - genetics</subject><subject>reproductive system</subject><subject>Reproductive trait</subject><subject>sequence analysis</subject><subject>single nucleotide polymorphism</subject><subject>Sow</subject><subject>sows</subject><subject>Swine - genetics</subject><subject>Swine - physiology</subject><issn>0378-4320</issn><issn>1873-2232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhL4C5lUOCPxP7SFfQIhVRiXK2HGfS9SqJt7a31f57HLYgTsDJ8uiZmVfzIPSWkpoS2rzf1nb2EXYxJOdrRiiviaoJpU_QiqqWV4xx9hStCG9VJTgjJ-hFSltCSNs0-jk6YYJwSaVcobvrMB6mEHcbn6aEw4DzBnAXZsA_q-EWZsje4bIsg59xi5cKPjv_ct2-w3busU0pOG-zD3P52_GQfMIPPm9wCg9LX7932d8DztH6nF6iZ4MdE7x6fE_RzaePN-vL6urrxef1h6vKCaly5Vqq-pa1WoueNoIJOwgubddJsFQw6KjVErTkQ6PpoOQAWkPnKO36VlLGT9HZcWwJcLeHlM3kk4NxtDOEfTJUMiEI00r_GxWCa12GNgXVR9SV26cIg9lFP9l4MJSYxY3Zmj_cmMWNIcoUN6X39eOafTdB_7vzl4wCvDkCgw3G3kafzPdvZYIo4oQs7v5KsEbxhVgfCSinvfcQTYkBs4O-hHLZ9MH_R9QfKSa5HA</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Feng, Xue</creator><creator>Xie, Shu-Yu</creator><creator>Zhou, Jian-She</creator><creator>Sun, Gui-Rong</creator><creator>Lu, Peng</creator><creator>Li, Ming</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20131101</creationdate><title>Polymorphisms of the bone morphogenetic protein 7 gene (BMP7) and association analysis with sow productive traits</title><author>Feng, Xue ; Xie, Shu-Yu ; Zhou, Jian-She ; Sun, Gui-Rong ; Lu, Peng ; Li, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-c718d727994d16424af435abb5ea142eb1a95e953f691f85fe99ebc11bd75123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>birth weight</topic><topic>BMP7 gene</topic><topic>Bone Morphogenetic Protein 7 - genetics</topic><topic>Bone Morphogenetic Protein 7 - metabolism</topic><topic>bone morphogenetic proteins</topic><topic>breeds</topic><topic>Female</topic><topic>Gene Expression Regulation - physiology</topic><topic>genes</topic><topic>Genotype</topic><topic>growth and development</topic><topic>Intron 2</topic><topic>litter size</topic><topic>Litter Size - genetics</topic><topic>litter weight</topic><topic>loci</topic><topic>piglets</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - physiology</topic><topic>quantitative trait loci</topic><topic>Reproduction - genetics</topic><topic>reproductive system</topic><topic>Reproductive trait</topic><topic>sequence analysis</topic><topic>single nucleotide polymorphism</topic><topic>Sow</topic><topic>sows</topic><topic>Swine - genetics</topic><topic>Swine - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feng, Xue</creatorcontrib><creatorcontrib>Xie, Shu-Yu</creatorcontrib><creatorcontrib>Zhou, Jian-She</creatorcontrib><creatorcontrib>Sun, Gui-Rong</creatorcontrib><creatorcontrib>Lu, Peng</creatorcontrib><creatorcontrib>Li, Ming</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Animal reproduction science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Xue</au><au>Xie, Shu-Yu</au><au>Zhou, Jian-She</au><au>Sun, Gui-Rong</au><au>Lu, Peng</au><au>Li, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms of the bone morphogenetic protein 7 gene (BMP7) and association analysis with sow productive traits</atitle><jtitle>Animal reproduction science</jtitle><addtitle>Anim Reprod Sci</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>142</volume><issue>1-2</issue><spage>56</spage><epage>62</epage><pages>56-62</pages><issn>0378-4320</issn><eissn>1873-2232</eissn><abstract>Bone morphological protein 7 (BMP7) has been proposed to be an osteoinductive protein. Recent data have shown that BMP7 also plays a crucial role in the growth and development, and physiological function of reproductive system. To date, studies have shown an association between the BMP gene family and reproduction in many populations, but few studies have completely described this association in sow. In the present study, three sow breeds were screened out to investigate the genetic effects of the BMP7 gene. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing, three single nucleotide polymorphisms (SNPs) (g.35161T>C, g.35175T>C and g.35216C>T) were identified in intron 2 of the BMP7 gene. Associations between the three SNPs and the number of piglet born alive (NBA), litter weight at birth (LBW), total number of piglet born (TNB) and litter weight at 21 days were analyzed using association analysis. Among the three SNPs, g.35161T>C was significantly associated with NBA and LBW (p<0.05), and the litter weight at 21 days (p<0.01). These results suggest that g.35161T>C is a potential candidate gene locus for litter size traits and the BMP7 gene might be associated with the quantitative trait locus (QTL) controlling the litter size. These data will provide a background for more extensive characterization of the BMP7 gene.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24035155</pmid><doi>10.1016/j.anireprosci.2013.08.011</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals birth weight BMP7 gene Bone Morphogenetic Protein 7 - genetics Bone Morphogenetic Protein 7 - metabolism bone morphogenetic proteins breeds Female Gene Expression Regulation - physiology genes Genotype growth and development Intron 2 litter size Litter Size - genetics litter weight loci piglets Polymorphism Polymorphism, Single Nucleotide - physiology quantitative trait loci Reproduction - genetics reproductive system Reproductive trait sequence analysis single nucleotide polymorphism Sow sows Swine - genetics Swine - physiology |
| title | Polymorphisms of the bone morphogenetic protein 7 gene (BMP7) and association analysis with sow productive traits |
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