Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis
Background Idiopathic rhinitis (IR) is a prevalent condition for which capsaicin nasal spray is the most effective treatment. However, the mechanisms underlying IR and the therapeutic action of capsaicin remain unknown. Objective We sought to investigate the molecular and cellular bases of IR and th...
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| creator | Van Gerven, Laura, MD Alpizar, Yeranddy A Wouters, Mira M., PhD Hox, Valérie, MD, PhD Hauben, Esther, MD, PhD Jorissen, Mark, MD, PhD Boeckxstaens, Guy, MD, PhD Talavera, Karel, PhD Hellings, Peter W., MD, PhD |
| description | Background Idiopathic rhinitis (IR) is a prevalent condition for which capsaicin nasal spray is the most effective treatment. However, the mechanisms underlying IR and the therapeutic action of capsaicin remain unknown. Objective We sought to investigate the molecular and cellular bases of IR and the therapeutic action of capsaicin. Methods Fourteen patients with IR and 12 healthy control subjects (HCs) were treated with intranasal capsaicin. The therapeutic effect was assessed in patients with IR by using visual analog scale and therapeutic response evaluation scores, and nasal hyperreactivity was evaluated by means of cold dry air provocation. Nasal samples served to measure the levels of neuromediators and expression of chemosensory cation channels, protein gene product 9.5 (PGP 9.5), and the mast cell marker c-kit. The effects of capsaicin were also tested in vitro on human nasal epithelial cells and mast cells. Results Patients with IR had higher baseline transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) expression in the nasal mucosa and higher concentrations of substance P (SP) in nasal secretions than HCs. Symptomatic relief was observed in 11 of 14 patients with IR after capsaicin treatment. Expression of TRPV1; transient receptor potential cation channel subfamily M, receptor 8 (TRPM8); and PGP 9.5 was only reduced in patients with IR after capsaicin treatment. Capsaicin did not alter c-KIT expression or nasal epithelial morphology in patients with IR and HCs nor did it induce apoptosis or necrosis in cultured human nasal epithelial cells and mast cells. Conclusion IR features an overexpression of TRPV1 in the nasal mucosa and increased SP levels in nasal secretions. Capsaicin exerts its therapeutic action by ablating the TRPV1-SP nociceptive signaling pathway in the nasal mucosa. |
| doi_str_mv | 10.1016/j.jaci.2013.08.026 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1524400726</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0091674913013407</els_id><sourcerecordid>3284928601</sourcerecordid><originalsourceid>FETCH-LOGICAL-c528t-46073755fb70f6790c1a371859997ad53b6d88f8e25e1790c7b0faa97871ebeb3</originalsourceid><addsrcrecordid>eNqNkt2KFDEQhRtR3NnVF_BCAiKs4IxJ_yUBEWTwDxYUXfc2pNPVTI093b1JetZ5G5_CB_DJrHbGXdgL8Sok9dVJJeckySPBF4KL8sV6sbYOFykX2YKrBU_LO8lMcC3npUqLu8mMcy3mpcz1UXIcwprTPlP6fnKU5iLTuc5nyc-lHYJFhx2LHmzcQBeZh3p0EFhng23ZajeAp5qLuMW4Y7aribVdwD3rYIi9Z0MfaY_U4GzEvmNuZbsOWhbGqrEbbHfs4vmvH9e8YKfnnz9diGes34KH74OHEKY-GmUgBRIL7ArjimGNPZ2s0DG_wg4jhgfJvca2AR4e1pPk69s358v387OP7z4sX5_NXZGqOM9LLjNZFE0leVNKzZ2wmRSq0FpLWxdZVdZKNQrSAsRUlhVvrNVSSQEVVNlJcrrXHXx_OUKIZoPBQdvaDvoxGFGkec65TMv_QIVWOdmjCX1yC133o-_oIROlNM-l5ESle8r5PgQPjRk8bqzfGcHNFACzNlMAzBQAw5Xhf6Z4fJAeqw3U1y1_HSfg6QGwwdm2ISMdhhtOFaWQUhL3cs8Bfe8WwZvgyBMHNZKF0dQ9_nuOV7faXUvW0Y3fYAfh5r0mpIabL1NUp6SKjERycu03T1zm6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1518904770</pqid></control><display><type>article</type><title>Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Van Gerven, Laura, MD ; Alpizar, Yeranddy A ; Wouters, Mira M., PhD ; Hox, Valérie, MD, PhD ; Hauben, Esther, MD, PhD ; Jorissen, Mark, MD, PhD ; Boeckxstaens, Guy, MD, PhD ; Talavera, Karel, PhD ; Hellings, Peter W., MD, PhD</creator><creatorcontrib>Van Gerven, Laura, MD ; Alpizar, Yeranddy A ; Wouters, Mira M., PhD ; Hox, Valérie, MD, PhD ; Hauben, Esther, MD, PhD ; Jorissen, Mark, MD, PhD ; Boeckxstaens, Guy, MD, PhD ; Talavera, Karel, PhD ; Hellings, Peter W., MD, PhD</creatorcontrib><description>Background Idiopathic rhinitis (IR) is a prevalent condition for which capsaicin nasal spray is the most effective treatment. However, the mechanisms underlying IR and the therapeutic action of capsaicin remain unknown. Objective We sought to investigate the molecular and cellular bases of IR and the therapeutic action of capsaicin. Methods Fourteen patients with IR and 12 healthy control subjects (HCs) were treated with intranasal capsaicin. The therapeutic effect was assessed in patients with IR by using visual analog scale and therapeutic response evaluation scores, and nasal hyperreactivity was evaluated by means of cold dry air provocation. Nasal samples served to measure the levels of neuromediators and expression of chemosensory cation channels, protein gene product 9.5 (PGP 9.5), and the mast cell marker c-kit. The effects of capsaicin were also tested in vitro on human nasal epithelial cells and mast cells. Results Patients with IR had higher baseline transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) expression in the nasal mucosa and higher concentrations of substance P (SP) in nasal secretions than HCs. Symptomatic relief was observed in 11 of 14 patients with IR after capsaicin treatment. Expression of TRPV1; transient receptor potential cation channel subfamily M, receptor 8 (TRPM8); and PGP 9.5 was only reduced in patients with IR after capsaicin treatment. Capsaicin did not alter c-KIT expression or nasal epithelial morphology in patients with IR and HCs nor did it induce apoptosis or necrosis in cultured human nasal epithelial cells and mast cells. Conclusion IR features an overexpression of TRPV1 in the nasal mucosa and increased SP levels in nasal secretions. Capsaicin exerts its therapeutic action by ablating the TRPV1-SP nociceptive signaling pathway in the nasal mucosa.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2013.08.026</identifier><identifier>PMID: 24139494</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; afferent nerves ; Allergies ; Allergy and Immunology ; Biological and medical sciences ; Capsaicin - administration & dosage ; Capsaicin - adverse effects ; Capsaicin treatment ; Cells, Cultured ; Cocaine ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gene Expression Regulation - drug effects ; Humans ; idiopathic rhinitis ; Immunopathology ; Male ; Mast Cells - metabolism ; Mast Cells - pathology ; Medical sciences ; Middle Aged ; nasal hyperreactivity ; Nasal Mucosa - metabolism ; Nasal Mucosa - pathology ; Nasal Sprays ; Neuropeptides ; Non tumoral diseases ; Nose ; Otolaryngology ; Otorhinolaryngology. Stomatology ; Proto-Oncogene Proteins c-kit - biosynthesis ; Rhinitis, Allergic, Perennial - drug therapy ; Rhinitis, Allergic, Perennial - metabolism ; Rhinitis, Allergic, Perennial - pathology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Sensory System Agents - administration & dosage ; Sensory System Agents - adverse effects ; TRPV Cation Channels - biosynthesis ; TRPV1 ; TRPV1-SP signaling pathway ; Ubiquitin Thiolesterase - biosynthesis ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Journal of allergy and clinical immunology, 2014-05, Vol.133 (5), p.1332-1339.e3</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2013 American Academy of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited May 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-46073755fb70f6790c1a371859997ad53b6d88f8e25e1790c7b0faa97871ebeb3</citedby><cites>FETCH-LOGICAL-c528t-46073755fb70f6790c1a371859997ad53b6d88f8e25e1790c7b0faa97871ebeb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674913013407$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28561777$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24139494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Gerven, Laura, MD</creatorcontrib><creatorcontrib>Alpizar, Yeranddy A</creatorcontrib><creatorcontrib>Wouters, Mira M., PhD</creatorcontrib><creatorcontrib>Hox, Valérie, MD, PhD</creatorcontrib><creatorcontrib>Hauben, Esther, MD, PhD</creatorcontrib><creatorcontrib>Jorissen, Mark, MD, PhD</creatorcontrib><creatorcontrib>Boeckxstaens, Guy, MD, PhD</creatorcontrib><creatorcontrib>Talavera, Karel, PhD</creatorcontrib><creatorcontrib>Hellings, Peter W., MD, PhD</creatorcontrib><title>Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background Idiopathic rhinitis (IR) is a prevalent condition for which capsaicin nasal spray is the most effective treatment. However, the mechanisms underlying IR and the therapeutic action of capsaicin remain unknown. Objective We sought to investigate the molecular and cellular bases of IR and the therapeutic action of capsaicin. Methods Fourteen patients with IR and 12 healthy control subjects (HCs) were treated with intranasal capsaicin. The therapeutic effect was assessed in patients with IR by using visual analog scale and therapeutic response evaluation scores, and nasal hyperreactivity was evaluated by means of cold dry air provocation. Nasal samples served to measure the levels of neuromediators and expression of chemosensory cation channels, protein gene product 9.5 (PGP 9.5), and the mast cell marker c-kit. The effects of capsaicin were also tested in vitro on human nasal epithelial cells and mast cells. Results Patients with IR had higher baseline transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) expression in the nasal mucosa and higher concentrations of substance P (SP) in nasal secretions than HCs. Symptomatic relief was observed in 11 of 14 patients with IR after capsaicin treatment. Expression of TRPV1; transient receptor potential cation channel subfamily M, receptor 8 (TRPM8); and PGP 9.5 was only reduced in patients with IR after capsaicin treatment. Capsaicin did not alter c-KIT expression or nasal epithelial morphology in patients with IR and HCs nor did it induce apoptosis or necrosis in cultured human nasal epithelial cells and mast cells. Conclusion IR features an overexpression of TRPV1 in the nasal mucosa and increased SP levels in nasal secretions. Capsaicin exerts its therapeutic action by ablating the TRPV1-SP nociceptive signaling pathway in the nasal mucosa.</description><subject>Adult</subject><subject>afferent nerves</subject><subject>Allergies</subject><subject>Allergy and Immunology</subject><subject>Biological and medical sciences</subject><subject>Capsaicin - administration & dosage</subject><subject>Capsaicin - adverse effects</subject><subject>Capsaicin treatment</subject><subject>Cells, Cultured</subject><subject>Cocaine</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Humans</subject><subject>idiopathic rhinitis</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Mast Cells - metabolism</subject><subject>Mast Cells - pathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>nasal hyperreactivity</subject><subject>Nasal Mucosa - metabolism</subject><subject>Nasal Mucosa - pathology</subject><subject>Nasal Sprays</subject><subject>Neuropeptides</subject><subject>Non tumoral diseases</subject><subject>Nose</subject><subject>Otolaryngology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Proto-Oncogene Proteins c-kit - biosynthesis</subject><subject>Rhinitis, Allergic, Perennial - drug therapy</subject><subject>Rhinitis, Allergic, Perennial - metabolism</subject><subject>Rhinitis, Allergic, Perennial - pathology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Sensory System Agents - administration & dosage</subject><subject>Sensory System Agents - adverse effects</subject><subject>TRPV Cation Channels - biosynthesis</subject><subject>TRPV1</subject><subject>TRPV1-SP signaling pathway</subject><subject>Ubiquitin Thiolesterase - biosynthesis</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt2KFDEQhRtR3NnVF_BCAiKs4IxJ_yUBEWTwDxYUXfc2pNPVTI093b1JetZ5G5_CB_DJrHbGXdgL8Sok9dVJJeckySPBF4KL8sV6sbYOFykX2YKrBU_LO8lMcC3npUqLu8mMcy3mpcz1UXIcwprTPlP6fnKU5iLTuc5nyc-lHYJFhx2LHmzcQBeZh3p0EFhng23ZajeAp5qLuMW4Y7aribVdwD3rYIi9Z0MfaY_U4GzEvmNuZbsOWhbGqrEbbHfs4vmvH9e8YKfnnz9diGes34KH74OHEKY-GmUgBRIL7ArjimGNPZ2s0DG_wg4jhgfJvca2AR4e1pPk69s358v387OP7z4sX5_NXZGqOM9LLjNZFE0leVNKzZ2wmRSq0FpLWxdZVdZKNQrSAsRUlhVvrNVSSQEVVNlJcrrXHXx_OUKIZoPBQdvaDvoxGFGkec65TMv_QIVWOdmjCX1yC133o-_oIROlNM-l5ESle8r5PgQPjRk8bqzfGcHNFACzNlMAzBQAw5Xhf6Z4fJAeqw3U1y1_HSfg6QGwwdm2ISMdhhtOFaWQUhL3cs8Bfe8WwZvgyBMHNZKF0dQ9_nuOV7faXUvW0Y3fYAfh5r0mpIabL1NUp6SKjERycu03T1zm6Q</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Van Gerven, Laura, MD</creator><creator>Alpizar, Yeranddy A</creator><creator>Wouters, Mira M., PhD</creator><creator>Hox, Valérie, MD, PhD</creator><creator>Hauben, Esther, MD, PhD</creator><creator>Jorissen, Mark, MD, PhD</creator><creator>Boeckxstaens, Guy, MD, PhD</creator><creator>Talavera, Karel, PhD</creator><creator>Hellings, Peter W., MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis</title><author>Van Gerven, Laura, MD ; Alpizar, Yeranddy A ; Wouters, Mira M., PhD ; Hox, Valérie, MD, PhD ; Hauben, Esther, MD, PhD ; Jorissen, Mark, MD, PhD ; Boeckxstaens, Guy, MD, PhD ; Talavera, Karel, PhD ; Hellings, Peter W., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-46073755fb70f6790c1a371859997ad53b6d88f8e25e1790c7b0faa97871ebeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>afferent nerves</topic><topic>Allergies</topic><topic>Allergy and Immunology</topic><topic>Biological and medical sciences</topic><topic>Capsaicin - administration & dosage</topic><topic>Capsaicin - adverse effects</topic><topic>Capsaicin treatment</topic><topic>Cells, Cultured</topic><topic>Cocaine</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Humans</topic><topic>idiopathic rhinitis</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Mast Cells - metabolism</topic><topic>Mast Cells - pathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>nasal hyperreactivity</topic><topic>Nasal Mucosa - metabolism</topic><topic>Nasal Mucosa - pathology</topic><topic>Nasal Sprays</topic><topic>Neuropeptides</topic><topic>Non tumoral diseases</topic><topic>Nose</topic><topic>Otolaryngology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Proto-Oncogene Proteins c-kit - biosynthesis</topic><topic>Rhinitis, Allergic, Perennial - drug therapy</topic><topic>Rhinitis, Allergic, Perennial - metabolism</topic><topic>Rhinitis, Allergic, Perennial - pathology</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Sensory System Agents - administration & dosage</topic><topic>Sensory System Agents - adverse effects</topic><topic>TRPV Cation Channels - biosynthesis</topic><topic>TRPV1</topic><topic>TRPV1-SP signaling pathway</topic><topic>Ubiquitin Thiolesterase - biosynthesis</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Gerven, Laura, MD</creatorcontrib><creatorcontrib>Alpizar, Yeranddy A</creatorcontrib><creatorcontrib>Wouters, Mira M., PhD</creatorcontrib><creatorcontrib>Hox, Valérie, MD, PhD</creatorcontrib><creatorcontrib>Hauben, Esther, MD, PhD</creatorcontrib><creatorcontrib>Jorissen, Mark, MD, PhD</creatorcontrib><creatorcontrib>Boeckxstaens, Guy, MD, PhD</creatorcontrib><creatorcontrib>Talavera, Karel, PhD</creatorcontrib><creatorcontrib>Hellings, Peter W., MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Gerven, Laura, MD</au><au>Alpizar, Yeranddy A</au><au>Wouters, Mira M., PhD</au><au>Hox, Valérie, MD, PhD</au><au>Hauben, Esther, MD, PhD</au><au>Jorissen, Mark, MD, PhD</au><au>Boeckxstaens, Guy, MD, PhD</au><au>Talavera, Karel, PhD</au><au>Hellings, Peter W., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>133</volume><issue>5</issue><spage>1332</spage><epage>1339.e3</epage><pages>1332-1339.e3</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background Idiopathic rhinitis (IR) is a prevalent condition for which capsaicin nasal spray is the most effective treatment. However, the mechanisms underlying IR and the therapeutic action of capsaicin remain unknown. Objective We sought to investigate the molecular and cellular bases of IR and the therapeutic action of capsaicin. Methods Fourteen patients with IR and 12 healthy control subjects (HCs) were treated with intranasal capsaicin. The therapeutic effect was assessed in patients with IR by using visual analog scale and therapeutic response evaluation scores, and nasal hyperreactivity was evaluated by means of cold dry air provocation. Nasal samples served to measure the levels of neuromediators and expression of chemosensory cation channels, protein gene product 9.5 (PGP 9.5), and the mast cell marker c-kit. The effects of capsaicin were also tested in vitro on human nasal epithelial cells and mast cells. Results Patients with IR had higher baseline transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) expression in the nasal mucosa and higher concentrations of substance P (SP) in nasal secretions than HCs. Symptomatic relief was observed in 11 of 14 patients with IR after capsaicin treatment. Expression of TRPV1; transient receptor potential cation channel subfamily M, receptor 8 (TRPM8); and PGP 9.5 was only reduced in patients with IR after capsaicin treatment. Capsaicin did not alter c-KIT expression or nasal epithelial morphology in patients with IR and HCs nor did it induce apoptosis or necrosis in cultured human nasal epithelial cells and mast cells. Conclusion IR features an overexpression of TRPV1 in the nasal mucosa and increased SP levels in nasal secretions. Capsaicin exerts its therapeutic action by ablating the TRPV1-SP nociceptive signaling pathway in the nasal mucosa.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>24139494</pmid><doi>10.1016/j.jaci.2013.08.026</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult afferent nerves Allergies Allergy and Immunology Biological and medical sciences Capsaicin - administration & dosage Capsaicin - adverse effects Capsaicin treatment Cells, Cultured Cocaine Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation - drug effects Humans idiopathic rhinitis Immunopathology Male Mast Cells - metabolism Mast Cells - pathology Medical sciences Middle Aged nasal hyperreactivity Nasal Mucosa - metabolism Nasal Mucosa - pathology Nasal Sprays Neuropeptides Non tumoral diseases Nose Otolaryngology Otorhinolaryngology. Stomatology Proto-Oncogene Proteins c-kit - biosynthesis Rhinitis, Allergic, Perennial - drug therapy Rhinitis, Allergic, Perennial - metabolism Rhinitis, Allergic, Perennial - pathology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sensory System Agents - administration & dosage Sensory System Agents - adverse effects TRPV Cation Channels - biosynthesis TRPV1 TRPV1-SP signaling pathway Ubiquitin Thiolesterase - biosynthesis Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis |
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