Avidity determines T‐cell reactivity in abacavir hypersensitivity

The antiretroviral drug abacavir (abc) elicits severe drug hypersensitivity reactions in HLA‐B*5701+ individuals. To understand the abc‐specific activation of CD8+ T cells, we generated abc‐specific T‐cell clones (abc‐TCCs). Abc reactivity could not be linked to the metabolism and/or processing of t...

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Veröffentlicht in:	European journal of immunology 2012-07, Vol.42 (7), p.1706-1716
Hauptverfasser:	Adam, Jacqueline, Eriksson, Klara K., Schnyder, Benno, Fontana, Stefano, Pichler, Werner J., Yerly, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Abacavir hypersensitivity Anti-HIV Agents - adverse effects Anti-HIV Agents - immunology Antibody Affinity Calcium - analysis Calcium - immunology CD8-Positive T-Lymphocytes - immunology Clone Cells Dideoxynucleosides - adverse effects Dideoxynucleosides - immunology Dose-Response Relationship, Drug Drug Hypersensitivity - etiology Drug Hypersensitivity - immunology HLA-B Antigens - immunology HLA‐B5701 Humans Kinetics Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Lymphocyte Activation Proteome - immunology Statistics, Nonparametric TCR avidity
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