Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock
Paeonol (2′‐hydroxy‐4′‐methoxyacetophenone) is the main phenolic compound of the radix of Paeonia suffruticosa which has been used as traditional Chinese medicine. In this study, we primarily investigated the anti‐inflammatory effects and the underlying mechanisms of paeonol in RAW macrophage cells;...
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| Veröffentlicht in: | Fundamental & clinical pharmacology 2014-06, Vol.28 (3), p.268-276 |
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| creator | Chen, Na Liu, Dianfeng Soromou, Lanan Wassy Sun, Jingjing Zhong, Weiting Guo, Weixiao Huo, Meixia Li, Hongyu Guan, Shuang Chen, Zhenwen Feng, Haihua |
| description | Paeonol (2′‐hydroxy‐4′‐methoxyacetophenone) is the main phenolic compound of the radix of Paeonia suffruticosa which has been used as traditional Chinese medicine. In this study, we primarily investigated the anti‐inflammatory effects and the underlying mechanisms of paeonol in RAW macrophage cells; and based on these effects, we assessed the protective effects of paeonol on lipopolysaccharide‐induced endotoxemia in mice. The in vitro study showed that paeonol regulated the production of TNF‐α, IL‐1β, IL‐6, and IL‐10 via inactivation of IκBα, ERK1/2, JNK, and p38 MAPK. In mouse model of lipopolysaccharide‐induced endotoxemia, pro‐ and anti‐inflammatory cytokines are significantly regulated, and thus the survival rates of lipolysaccharide‐challenged mice are improved by paeonol (150, 200, or 250 mg/kg). Therefore, paeonol has a beneficial activity against lipopolysaccharide‐induced inflammation in RAW 264.7 cell and mouse models. |
| doi_str_mv | 10.1111/fcp.12019 |
| format | Article |
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In this study, we primarily investigated the anti‐inflammatory effects and the underlying mechanisms of paeonol in RAW macrophage cells; and based on these effects, we assessed the protective effects of paeonol on lipopolysaccharide‐induced endotoxemia in mice. The in vitro study showed that paeonol regulated the production of TNF‐α, IL‐1β, IL‐6, and IL‐10 via inactivation of IκBα, ERK1/2, JNK, and p38 MAPK. In mouse model of lipopolysaccharide‐induced endotoxemia, pro‐ and anti‐inflammatory cytokines are significantly regulated, and thus the survival rates of lipolysaccharide‐challenged mice are improved by paeonol (150, 200, or 250 mg/kg). Therefore, paeonol has a beneficial activity against lipopolysaccharide‐induced inflammation in RAW 264.7 cell and mouse models.</description><identifier>ISSN: 0767-3981</identifier><identifier>EISSN: 1472-8206</identifier><identifier>DOI: 10.1111/fcp.12019</identifier><identifier>PMID: 23413967</identifier><identifier>CODEN: FCPHEZ</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject><![CDATA[Acetophenones - administration & dosage ; Acetophenones - isolation & purification ; Acetophenones - pharmacology ; Acetophenones - therapeutic use ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Biological and medical sciences ; Cell Culture Techniques ; Cell Line ; Cell Survival - drug effects ; cytokines ; Cytokines - antagonists & inhibitors ; Cytokines - blood ; Cytokines - immunology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; lipopolysaccharide ; Lipopolysaccharides - toxicity ; Macrophages - drug effects ; Macrophages - immunology ; Medical sciences ; Mice, Inbred C57BL ; Paeonia ; Paeonia - chemistry ; paeonol ; pathway ; Pharmacology. Drug treatments ; Plant Roots - chemistry ; Shock, Septic - blood ; Shock, Septic - immunology ; Shock, Septic - prevention & control ; survival]]></subject><ispartof>Fundamental & clinical pharmacology, 2014-06, Vol.28 (3), p.268-276</ispartof><rights>2013 The Authors Fundamental and Clinical Pharmacology © 2013 Société Française de Pharmacologie et de Thérapeutique</rights><rights>2015 INIST-CNRS</rights><rights>2013 The Authors Fundamental and Clinical Pharmacology © 2013 Société Française de Pharmacologie et de Thérapeutique.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4269-b131f710345693270bbbe67e5dd6cda7acd762b6540ec623d1e7feeef3dfbd583</citedby><cites>FETCH-LOGICAL-c4269-b131f710345693270bbbe67e5dd6cda7acd762b6540ec623d1e7feeef3dfbd583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ffcp.12019$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ffcp.12019$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28391886$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23413967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Na</creatorcontrib><creatorcontrib>Liu, Dianfeng</creatorcontrib><creatorcontrib>Soromou, Lanan Wassy</creatorcontrib><creatorcontrib>Sun, Jingjing</creatorcontrib><creatorcontrib>Zhong, Weiting</creatorcontrib><creatorcontrib>Guo, Weixiao</creatorcontrib><creatorcontrib>Huo, Meixia</creatorcontrib><creatorcontrib>Li, Hongyu</creatorcontrib><creatorcontrib>Guan, Shuang</creatorcontrib><creatorcontrib>Chen, Zhenwen</creatorcontrib><creatorcontrib>Feng, Haihua</creatorcontrib><title>Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock</title><title>Fundamental & clinical pharmacology</title><addtitle>Fundam Clin Pharmacol</addtitle><description>Paeonol (2′‐hydroxy‐4′‐methoxyacetophenone) is the main phenolic compound of the radix of Paeonia suffruticosa which has been used as traditional Chinese medicine. In this study, we primarily investigated the anti‐inflammatory effects and the underlying mechanisms of paeonol in RAW macrophage cells; and based on these effects, we assessed the protective effects of paeonol on lipopolysaccharide‐induced endotoxemia in mice. The in vitro study showed that paeonol regulated the production of TNF‐α, IL‐1β, IL‐6, and IL‐10 via inactivation of IκBα, ERK1/2, JNK, and p38 MAPK. In mouse model of lipopolysaccharide‐induced endotoxemia, pro‐ and anti‐inflammatory cytokines are significantly regulated, and thus the survival rates of lipolysaccharide‐challenged mice are improved by paeonol (150, 200, or 250 mg/kg). Therefore, paeonol has a beneficial activity against lipopolysaccharide‐induced inflammation in RAW 264.7 cell and mouse models.</description><subject>Acetophenones - administration & dosage</subject><subject>Acetophenones - isolation & purification</subject><subject>Acetophenones - pharmacology</subject><subject>Acetophenones - therapeutic use</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cell Culture Techniques</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>cytokines</subject><subject>Cytokines - antagonists & inhibitors</subject><subject>Cytokines - blood</subject><subject>Cytokines - immunology</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>lipopolysaccharide</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - immunology</subject><subject>Medical sciences</subject><subject>Mice, Inbred C57BL</subject><subject>Paeonia</subject><subject>Paeonia - chemistry</subject><subject>paeonol</subject><subject>pathway</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Roots - chemistry</subject><subject>Shock, Septic - blood</subject><subject>Shock, Septic - immunology</subject><subject>Shock, Septic - prevention & control</subject><subject>survival</subject><issn>0767-3981</issn><issn>1472-8206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EokNhwQsgb5BgkdaOEztZoiktiAKtBIKd5djXjBknDnYimhfgufEw07JCwhtvvvOjexB6SskJze_U6vGEloS299CKVqIsmpLw-2hFBBcFaxt6hB6l9J0QKgjlD9FRySrKWi5W6NeVgjAEj9M8jhFSgoS9G8MY_JKU1hsVnYHCDWbWYLAbrFd9r6YQF6yXKWzdkBVuwL3SMYwb9Q2wBu8TVoPBYwwT6Cnh3mnANoYee5g2ymMYTJjCTRamTdDbx-iBVT7Bk8N_jD6fv_60flNcfrx4u351Weiq5G3RUUatoIRVNW9ZKUjXdcAF1MZwbZRQ2ghedryuCGheMkNBWACwzNjO1A07Ri_2vrnZjxnSJHuXdn3VAGFOktZlxdq2acV_oFRUJFfZub7co_kEKUWwcoyuV3GRlMjdQjIvJP8slNlnB9u568HckbeTZOD5AVBJK2-jGrRLf7mGtbRpeOZO99xP52H5d6I8X1_dRhd7hUsT3NwpVNzKnCtq-eXDhTx7f83endXX8iv7Db4Puk8</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Chen, Na</creator><creator>Liu, Dianfeng</creator><creator>Soromou, Lanan Wassy</creator><creator>Sun, Jingjing</creator><creator>Zhong, Weiting</creator><creator>Guo, Weixiao</creator><creator>Huo, Meixia</creator><creator>Li, Hongyu</creator><creator>Guan, Shuang</creator><creator>Chen, Zhenwen</creator><creator>Feng, Haihua</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>201406</creationdate><title>Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock</title><author>Chen, Na ; Liu, Dianfeng ; Soromou, Lanan Wassy ; Sun, Jingjing ; Zhong, Weiting ; Guo, Weixiao ; Huo, Meixia ; Li, Hongyu ; Guan, Shuang ; Chen, Zhenwen ; Feng, Haihua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4269-b131f710345693270bbbe67e5dd6cda7acd762b6540ec623d1e7feeef3dfbd583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetophenones - administration & dosage</topic><topic>Acetophenones - isolation & purification</topic><topic>Acetophenones - pharmacology</topic><topic>Acetophenones - therapeutic use</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cell Culture Techniques</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>cytokines</topic><topic>Cytokines - antagonists & inhibitors</topic><topic>Cytokines - blood</topic><topic>Cytokines - immunology</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>lipopolysaccharide</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - immunology</topic><topic>Medical sciences</topic><topic>Mice, Inbred C57BL</topic><topic>Paeonia</topic><topic>Paeonia - chemistry</topic><topic>paeonol</topic><topic>pathway</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Roots - chemistry</topic><topic>Shock, Septic - blood</topic><topic>Shock, Septic - immunology</topic><topic>Shock, Septic - prevention & control</topic><topic>survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Na</creatorcontrib><creatorcontrib>Liu, Dianfeng</creatorcontrib><creatorcontrib>Soromou, Lanan Wassy</creatorcontrib><creatorcontrib>Sun, Jingjing</creatorcontrib><creatorcontrib>Zhong, Weiting</creatorcontrib><creatorcontrib>Guo, Weixiao</creatorcontrib><creatorcontrib>Huo, Meixia</creatorcontrib><creatorcontrib>Li, Hongyu</creatorcontrib><creatorcontrib>Guan, Shuang</creatorcontrib><creatorcontrib>Chen, Zhenwen</creatorcontrib><creatorcontrib>Feng, Haihua</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Fundamental & clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Na</au><au>Liu, Dianfeng</au><au>Soromou, Lanan Wassy</au><au>Sun, Jingjing</au><au>Zhong, Weiting</au><au>Guo, Weixiao</au><au>Huo, Meixia</au><au>Li, Hongyu</au><au>Guan, Shuang</au><au>Chen, Zhenwen</au><au>Feng, Haihua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock</atitle><jtitle>Fundamental & clinical pharmacology</jtitle><addtitle>Fundam Clin Pharmacol</addtitle><date>2014-06</date><risdate>2014</risdate><volume>28</volume><issue>3</issue><spage>268</spage><epage>276</epage><pages>268-276</pages><issn>0767-3981</issn><eissn>1472-8206</eissn><coden>FCPHEZ</coden><abstract>Paeonol (2′‐hydroxy‐4′‐methoxyacetophenone) is the main phenolic compound of the radix of Paeonia suffruticosa which has been used as traditional Chinese medicine. In this study, we primarily investigated the anti‐inflammatory effects and the underlying mechanisms of paeonol in RAW macrophage cells; and based on these effects, we assessed the protective effects of paeonol on lipopolysaccharide‐induced endotoxemia in mice. The in vitro study showed that paeonol regulated the production of TNF‐α, IL‐1β, IL‐6, and IL‐10 via inactivation of IκBα, ERK1/2, JNK, and p38 MAPK. In mouse model of lipopolysaccharide‐induced endotoxemia, pro‐ and anti‐inflammatory cytokines are significantly regulated, and thus the survival rates of lipolysaccharide‐challenged mice are improved by paeonol (150, 200, or 250 mg/kg). Therefore, paeonol has a beneficial activity against lipopolysaccharide‐induced inflammation in RAW 264.7 cell and mouse models.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>23413967</pmid><doi>10.1111/fcp.12019</doi><tpages>9</tpages></addata></record> |
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| ispartof | Fundamental & clinical pharmacology, 2014-06, Vol.28 (3), p.268-276 |
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| subjects | Acetophenones - administration & dosage Acetophenones - isolation & purification Acetophenones - pharmacology Acetophenones - therapeutic use Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Cell Culture Techniques Cell Line Cell Survival - drug effects cytokines Cytokines - antagonists & inhibitors Cytokines - blood Cytokines - immunology Disease Models, Animal Dose-Response Relationship, Drug Female lipopolysaccharide Lipopolysaccharides - toxicity Macrophages - drug effects Macrophages - immunology Medical sciences Mice, Inbred C57BL Paeonia Paeonia - chemistry paeonol pathway Pharmacology. Drug treatments Plant Roots - chemistry Shock, Septic - blood Shock, Septic - immunology Shock, Septic - prevention & control survival |
| title | Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock |
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