Experimental infection and comparative genomic analysis of a highly pathogenic PRRSV-HBR strain at different passage levels

A highly pathogenic strain of porcine reproductive and respiratory syndrome virus (PRRSV-HBR) was passaged on Marc-145 cells for 125 passages. In order to elucidate the change in virulence of PRRSV-HBR strain during the process of passage in vitro, swine infection experiment was performed with the v...

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Veröffentlicht in:	Veterinary microbiology 2013-10, Vol.166 (3-4), p.337-346
Hauptverfasser:	Wei, Yanwu, Li, Shengbin, Huang, Liping, Tang, Qinghai, Liu, Jianbo, Liu, Dan, Wang, Yiping, Wu, Hongli, Liu, Changming
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amino acids Animals Comparative Genomic Hybridization genes Genetic variation Genome, Viral genomics Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) Molecular Sequence Data Mutation nucleotide sequences porcine reproductive and respiratory syndrome Porcine Reproductive and Respiratory Syndrome - virology Porcine reproductive and respiratory syndrome virus Porcine respiratory and reproductive syndrome virus Porcine respiratory and reproductive syndrome virus - chemistry Porcine respiratory and reproductive syndrome virus - genetics Porcine respiratory and reproductive syndrome virus - isolation & purification Porcine respiratory and reproductive syndrome virus - pathogenicity Sequence Alignment sequence analysis Sequence Deletion Serial Passage structural proteins Swine Vaccine candidate Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Structural Proteins - chemistry Viral Structural Proteins - genetics Virulence Virulence change viruses
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