Selective N-Alkylation of β-Alanine Facilitates the Synthesis of a Poly(amino acid)-Based Theranostic Nanoagent

The development of functional amino acid-based polymeric materials is emerging as a platform to create biodegradable and nontoxic nanomaterials for medical and biotechnology applications. In particular, facile synthetic routes for these polymers and their corresponding polymeric nanomaterials would...

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Veröffentlicht in:	Biomacromolecules 2011-11, Vol.12 (11), p.3917-3927
Hauptverfasser:	Santra, Santimukul, Perez, J. Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Agents, Phytogenic - pharmacology Applied sciences beta-Alanine - chemistry Biological and medical sciences Biopolymers Cell Line, Tumor Exact sciences and technology Fluorescent Dyes - pharmacokinetics Folic Acid - chemistry Folic Acid Transporters - metabolism General pharmacology Humans Hydrophobic and Hydrophilic Interactions Light Medical sciences Molecular Weight Nanocapsules - chemistry Neoplasms - diagnosis Neoplasms - drug therapy Organic polymers Paclitaxel - pharmacokinetics Paclitaxel - pharmacology Particle Size Peptides - chemical synthesis Peptides - pharmacokinetics Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts Scattering, Radiation
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