Elimination Kinetics of Domoic Acid from the Brain and Cerebrospinal Fluid of the Pregnant Rat

Domoic acid (DA) causes neurological effects in multiple species upon exposure, including status epilepticus in pregnant sea lions and an epileptic disease state that commonly develops in juveniles. This study aims to define brain toxicokinetic parameters in the pregnant rat in the larger context of...

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Veröffentlicht in:	Chemical research in toxicology 2012-12, Vol.25 (12), p.2805-2809
Hauptverfasser:	Maucher Fuquay, Jennifer, Muha, Noah, Wang, Zhihong, Ramsdell, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Female Kainic Acid - analogs & derivatives Kainic Acid - blood Kainic Acid - cerebrospinal fluid Kainic Acid - pharmacokinetics Marine Toxins - blood Marine Toxins - cerebrospinal fluid Marine Toxins - pharmacokinetics Neurotoxins - blood Neurotoxins - cerebrospinal fluid Neurotoxins - pharmacokinetics Pregnancy Rats Rats, Sprague-Dawley
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