CD46: The ‘multitasker’ of complement proteins
Complement is undeniably quintessential for innate immunity by detecting and eliminating infectious microorganisms. Recent work, however, highlights an equally profound impact of complement on the induction and regulation of a wide range of immune cells. In particular, the complement regulator CD46...
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| Veröffentlicht in: | The international journal of biochemistry & cell biology 2013-12, Vol.45 (12), p.2808-2820 |
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| container_end_page | 2820 |
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| container_issue | 12 |
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| container_title | The international journal of biochemistry & cell biology |
| container_volume | 45 |
| creator | Yamamoto, Hidekazu Fara, Antonella Francesca Dasgupta, Prokar Kemper, Claudia |
| description | Complement is undeniably quintessential for innate immunity by detecting and eliminating infectious microorganisms. Recent work, however, highlights an equally profound impact of complement on the induction and regulation of a wide range of immune cells. In particular, the complement regulator CD46 emerges as a key sensor of immune activation and a vital modulator of adaptive immunity. In this review, we summarize the current knowledge of CD46-mediated signalling events and their functional consequences on immune-competent cells with a specific focus on those in CD4+ T cells. We will also discuss the promises and challenges that potential therapeutic modulation of CD46 may hold and pose. |
| doi_str_mv | 10.1016/j.biocel.2013.09.016 |
| format | Article |
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| identifier | ISSN: 1357-2725 |
| ispartof | The international journal of biochemistry & cell biology, 2013-12, Vol.45 (12), p.2808-2820 |
| issn | 1357-2725 1878-5875 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | adaptive immunity Autoimmunity Biochemistry Biology CD4-positive T-lymphocytes CD46 Complement Complement System Proteins - immunology Control Humans Immunity Immunity, Innate Infection innate immunity Membrane Cofactor Protein - immunology microorganisms Modulation Modulators proteins Regulators Signal Transduction Th1 cells |
| title | CD46: The ‘multitasker’ of complement proteins |
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