Tumor location-dependent skip lateral cervical lymph node metastasis in papillary thyroid cancer
Background Lateral cervical lymph node metastasis without central lymph node (CLN) metastasis is not infrequent in papillary thyroid cancer (PTC). This study was designed to investigate the frequency and pattern of skip metastasis in PTC. Methods We reviewed 131 patients who underwent total thyroide...
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| Veröffentlicht in: | Head & neck 2014-06, Vol.36 (6), p.887-891 |
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| container_title | Head & neck |
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| creator | Lee, Yoon Se Shin, Sung-Chan Lim, Yun-Sung Lee, Jin-Choon Wang, Soo-Geun Son, Seok-Man Kim, In-Ju Lee, Byung-Joo |
| description | Background
Lateral cervical lymph node metastasis without central lymph node (CLN) metastasis is not infrequent in papillary thyroid cancer (PTC). This study was designed to investigate the frequency and pattern of skip metastasis in PTC.
Methods
We reviewed 131 patients who underwent total thyroidectomy with CLN dissection and selective lymph node dissection. Tumor location was classified in 3 areas (upper, middle, and lower third) based on preoperative ultrasonographic findings.
Results
All skip metastases occurred in patients whose tumors had been on the upper part of the thyroid (p |
| doi_str_mv | 10.1002/hed.23391 |
| format | Article |
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Lateral cervical lymph node metastasis without central lymph node (CLN) metastasis is not infrequent in papillary thyroid cancer (PTC). This study was designed to investigate the frequency and pattern of skip metastasis in PTC.
Methods
We reviewed 131 patients who underwent total thyroidectomy with CLN dissection and selective lymph node dissection. Tumor location was classified in 3 areas (upper, middle, and lower third) based on preoperative ultrasonographic findings.
Results
All skip metastases occurred in patients whose tumors had been on the upper part of the thyroid (p < .001). Among 9 patients with skip metastasis, level III lymph nodes (66.7%) were the lymph nodes that were most frequently involved in skip metastasis.
Conclusion
Primary tumors in the upper portion of the thyroid are closely linked to skip metastasis. Careful preoperative evaluation of lateral cervical lymph nodes is suggested when a tumor is in the upper portion. © 2013 Wiley Periodicals, Inc. Head Neck 36: 887–891, 2014</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.23391</identifier><identifier>PMID: 23733708</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Carcinoma - pathology ; Carcinoma - secondary ; Carcinoma - surgery ; Carcinoma, Papillary ; Child ; Cross-Sectional Studies ; Female ; Humans ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis ; Male ; Middle Aged ; neck dissection ; Neck Dissection - methods ; Neoplasm Invasiveness ; Neoplasm Staging ; papillary thyroid carcinoma ; skip ; Thyroid Cancer, Papillary ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - secondary ; Thyroid Neoplasms - surgery ; Thyroidectomy - methods ; Treatment Outcome ; univariate analysis</subject><ispartof>Head & neck, 2014-06, Vol.36 (6), p.887-891</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3571-afb70525b9d50b492278c9c43ca4c8e23cd9947d51f5beb052c6fc5805a48fcf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.23391$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.23391$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23733708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Yoon Se</creatorcontrib><creatorcontrib>Shin, Sung-Chan</creatorcontrib><creatorcontrib>Lim, Yun-Sung</creatorcontrib><creatorcontrib>Lee, Jin-Choon</creatorcontrib><creatorcontrib>Wang, Soo-Geun</creatorcontrib><creatorcontrib>Son, Seok-Man</creatorcontrib><creatorcontrib>Kim, In-Ju</creatorcontrib><creatorcontrib>Lee, Byung-Joo</creatorcontrib><title>Tumor location-dependent skip lateral cervical lymph node metastasis in papillary thyroid cancer</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Lateral cervical lymph node metastasis without central lymph node (CLN) metastasis is not infrequent in papillary thyroid cancer (PTC). This study was designed to investigate the frequency and pattern of skip metastasis in PTC.
Methods
We reviewed 131 patients who underwent total thyroidectomy with CLN dissection and selective lymph node dissection. Tumor location was classified in 3 areas (upper, middle, and lower third) based on preoperative ultrasonographic findings.
Results
All skip metastases occurred in patients whose tumors had been on the upper part of the thyroid (p < .001). Among 9 patients with skip metastasis, level III lymph nodes (66.7%) were the lymph nodes that were most frequently involved in skip metastasis.
Conclusion
Primary tumors in the upper portion of the thyroid are closely linked to skip metastasis. Careful preoperative evaluation of lateral cervical lymph nodes is suggested when a tumor is in the upper portion. © 2013 Wiley Periodicals, Inc. Head Neck 36: 887–891, 2014</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - secondary</subject><subject>Carcinoma - surgery</subject><subject>Carcinoma, Papillary</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>neck dissection</subject><subject>Neck Dissection - methods</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>papillary thyroid carcinoma</subject><subject>skip</subject><subject>Thyroid Cancer, Papillary</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - secondary</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy - methods</subject><subject>Treatment Outcome</subject><subject>univariate analysis</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtrHDEQhEWIiR_JIX8gCHzJZWxJLa1mjmb9CiwxJA6BXBSN1MPKnpelmdj776P1Oj4EBCror0S1ipCPnJ1wxsTpGv2JAKj4G3LAWaULBlK_3WoJBTAt98lhSneMMVhI8Y7sC9AAmpUH5Pft3A2RtoOzUxj6wuOIvcd-ouk-jLS1E0bbUofxT3BZtJtuXNN-8Eg7nGzKJyQaejraMbStjRs6rTdxCJ4622fbe7LX2Dbhh5f7iPy4vLhdXherm6svy7NV4UBpXtim1kwJVVdesVpWQujSVU6Cs9KVKMD5qpLaK96oGuuMukXjVMmUlWXjGjgin3fvjnF4mDFNpgvJYY7U4zAnw5WQIKUEltHj_9C7YY59TrelQFfAhMrUpxdqrjv0Zoyhy-uZf3-XgdMd8Bha3LzOOTPbUkwuxTyXYq4vzp9FdhQ7R0gTPr06bLw3Cw1amZ9fr8yv5eobX55z8x3-AuV6jeg</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Lee, Yoon Se</creator><creator>Shin, Sung-Chan</creator><creator>Lim, Yun-Sung</creator><creator>Lee, Jin-Choon</creator><creator>Wang, Soo-Geun</creator><creator>Son, Seok-Man</creator><creator>Kim, In-Ju</creator><creator>Lee, Byung-Joo</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201406</creationdate><title>Tumor location-dependent skip lateral cervical lymph node metastasis in papillary thyroid cancer</title><author>Lee, Yoon Se ; Shin, Sung-Chan ; Lim, Yun-Sung ; Lee, Jin-Choon ; Wang, Soo-Geun ; Son, Seok-Man ; Kim, In-Ju ; Lee, Byung-Joo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3571-afb70525b9d50b492278c9c43ca4c8e23cd9947d51f5beb052c6fc5805a48fcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - secondary</topic><topic>Carcinoma - surgery</topic><topic>Carcinoma, Papillary</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>neck dissection</topic><topic>Neck Dissection - methods</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>papillary thyroid carcinoma</topic><topic>skip</topic><topic>Thyroid Cancer, Papillary</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - secondary</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy - methods</topic><topic>Treatment Outcome</topic><topic>univariate analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Yoon Se</creatorcontrib><creatorcontrib>Shin, Sung-Chan</creatorcontrib><creatorcontrib>Lim, Yun-Sung</creatorcontrib><creatorcontrib>Lee, Jin-Choon</creatorcontrib><creatorcontrib>Wang, Soo-Geun</creatorcontrib><creatorcontrib>Son, Seok-Man</creatorcontrib><creatorcontrib>Kim, In-Ju</creatorcontrib><creatorcontrib>Lee, Byung-Joo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Yoon Se</au><au>Shin, Sung-Chan</au><au>Lim, Yun-Sung</au><au>Lee, Jin-Choon</au><au>Wang, Soo-Geun</au><au>Son, Seok-Man</au><au>Kim, In-Ju</au><au>Lee, Byung-Joo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor location-dependent skip lateral cervical lymph node metastasis in papillary thyroid cancer</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2014-06</date><risdate>2014</risdate><volume>36</volume><issue>6</issue><spage>887</spage><epage>891</epage><pages>887-891</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Lateral cervical lymph node metastasis without central lymph node (CLN) metastasis is not infrequent in papillary thyroid cancer (PTC). This study was designed to investigate the frequency and pattern of skip metastasis in PTC.
Methods
We reviewed 131 patients who underwent total thyroidectomy with CLN dissection and selective lymph node dissection. Tumor location was classified in 3 areas (upper, middle, and lower third) based on preoperative ultrasonographic findings.
Results
All skip metastases occurred in patients whose tumors had been on the upper part of the thyroid (p < .001). Among 9 patients with skip metastasis, level III lymph nodes (66.7%) were the lymph nodes that were most frequently involved in skip metastasis.
Conclusion
Primary tumors in the upper portion of the thyroid are closely linked to skip metastasis. Careful preoperative evaluation of lateral cervical lymph nodes is suggested when a tumor is in the upper portion. © 2013 Wiley Periodicals, Inc. Head Neck 36: 887–891, 2014</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23733708</pmid><doi>10.1002/hed.23391</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Carcinoma - pathology Carcinoma - secondary Carcinoma - surgery Carcinoma, Papillary Child Cross-Sectional Studies Female Humans Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis Male Middle Aged neck dissection Neck Dissection - methods Neoplasm Invasiveness Neoplasm Staging papillary thyroid carcinoma skip Thyroid Cancer, Papillary Thyroid Neoplasms - pathology Thyroid Neoplasms - secondary Thyroid Neoplasms - surgery Thyroidectomy - methods Treatment Outcome univariate analysis |
| title | Tumor location-dependent skip lateral cervical lymph node metastasis in papillary thyroid cancer |
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