High uric acid directly inhibits insulin signalling and induces insulin resistance

•Hyperuricemic mice showed impaired glucose tolerance with insulin resistance.•Hyperuricemia inhibited insulin signaling in liver, muscle and fat tissues.•HUA levels induced oxidative stress in HepG2 cells.•NAC blocked the HUA-induced insulin signalling impairment in HepG2 cells. Accumulating clinic...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-05, Vol.447 (4), p.707-714
Hauptverfasser:	Zhu, Yuzhang, Hu, Yaqiu, Huang, Tianliang, Zhang, Yongneng, Li, Zhi, Luo, Chaohuan, Luo, Yinfeng, Yuan, Huier, Hisatome, Ichiro, Yamamoto, Tetsuya, Cheng, Jidong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Akt Animals Antioxidants - pharmacology Disease Models, Animal Glucose Intolerance - etiology Glucose Intolerance - metabolism Hep G2 Cells Humans Hyperuricemia - complications Hyperuricemia - metabolism Insulin - metabolism Insulin Receptor Substrate Proteins - antagonists & inhibitors Insulin Receptor Substrate Proteins - chemistry Insulin Receptor Substrate Proteins - metabolism Insulin resistance Insulin Resistance - physiology IRS1 Male Mice Mice, Inbred C57BL Oxidative Stress Phosphorylation Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - chemistry Proto-Oncogene Proteins c-akt - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction Uric acid Uric Acid - metabolism
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