SGK-1 Regulates Inflammation and Cell Death in the Ischemic-Reperfused Heart: Pressure-Related Effects

BACKGROUND Systemic hypertension and the associated increased myocardial load/mechanical stress are common in patients with coronary heart disease. Thus, unraveling of mechanosensitive molecular mechanisms that determine cell fate in the setting of cardiac tissue injury is of scientific and clinical...

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Veröffentlicht in:	American journal of hypertension 2014-06, Vol.27 (6), p.846-856
Hauptverfasser:	Baban, Babak, Liu, Jun Yao, Mozaffari, Mahmood S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Blood Pressure Cardiovascular disease Cell death Cytokines DNA damage Enzyme Activation Gene expression Heart Hypertension Immediate-Early Proteins - antagonists & inhibitors Immediate-Early Proteins - metabolism In Vitro Techniques Inflammation Inflammation - enzymology Inflammation - immunology Inflammation - pathology Inflammation - physiopathology Inflammation - prevention & control Inflammation Mediators - metabolism Interleukin-10 - metabolism Interleukin-17 - metabolism Interleukin-27 - metabolism Ischemia Kinases Male Mechanotransduction, Cellular Membrane Potential, Mitochondrial Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - immunology Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - enzymology Myocardium - immunology Myocardium - pathology Necrosis Perfusion Phosphorylation Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Proteins Rats, Sprague-Dawley Transcription Factor CHOP - metabolism
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