Quantitation OF ARGS aggrecan fragments in synovial fluid, serum and urine from osteoarthritis patients

Summary Objective To characterise ARGS neoepitope concentrations in various matrices from patients with knee osteoarthritis (OA) and assess performance of an immunoassay to facilitate clinical development of therapeutics affecting the A disintegrin and metalloproteinase with thrombospondin motifs 5...

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Veröffentlicht in:	Osteoarthritis and cartilage 2014-05, Vol.22 (5), p.690-697
Hauptverfasser:	Germaschewski, F.M, Matheny, C.J, Larkin, J, Liu, F, Thomas, L.R, Saunders, J.S, Sully, K, Whittall, C, Boyle, Y, Peters, G, Graham, N.M
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - chemistry ADAMTS5 Protein Aged Aggrecan Aggrecans - metabolism ARGS Arthroplasty, Replacement, Knee Biomarker Biomarkers - metabolism Case-Control Studies Circadian Rhythm - physiology Epitopes - metabolism Female Humans Immunoassay Luminescent Measurements - methods Male Middle Aged Neoepitope Osteoarthritis Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - surgery Peptide Fragments - metabolism Rheumatology Synovial Fluid - metabolism
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