Qualification and application of a liquid chromatography–tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction

A liquid chromatographic–tandem mass spectrometric (LC–MS/MS) method was developed and applied for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma to support preclinical pharmacodynamics studies. The method consisted of micro-elution solid phase extraction for sample...

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Veröffentlicht in:	Archives of pharmacal research 2014-05, Vol.37 (5), p.636-644
Hauptverfasser:	Shin, Young G., Hamm, Lee, Murakami, Stanley, Buirst, Kenji, Buonarati, Michael H., Cox, April, Regal, Kelly, Hunt, Kevin W., Scearce-Levie, Kimberly, Watts, Ryan J., Liu, Xingrong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - blood Amyloid beta-Peptides - genetics Animals Calibration Chromatography, Liquid - standards Enzyme-Linked Immunosorbent Assay Humans Medicine Mice, Inbred C57BL Mice, Transgenic Peptide Fragments - blood Peptide Fragments - genetics Pharmacology/Toxicology Pharmacy Quality Control Reference Standards Reproducibility of Results Research Article Solid Phase Microextraction - standards Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry - standards
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